File:Integumentary touch dome model 03.jpg

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Model for developmental signaling requirements for touch dome Merkel cell production

The touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs).

Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin.

TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages.

Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.

Integumentary Links: integumentary | Lecture | hair | tooth | nail | integumentary gland | mammary gland | vernix caseosa | melanocyte | touch | Eyelid | outer ear | Histology | integumentary abnormalities | Category:Integumentary
Hair Links  
Hair Links: Overview | Lanugo | Neonatal | Vellus | Terminal | Hair Follicle | Follicle Phases | Stem Cells | Molecular | Pattern | Puberty | Histology | Hair Colour | Arrector Pili Muscle | Hair Loss | Integumentary
Touch Links  
Touch Links: Touch Receptors | Touch Pathway | Pacinian Corpuscle | Meissner's Corpuscle | Merkel Cell | Sensory Modalities | Neural Crest Development | Neural System Development | Student project | Integumentary | Sensory System
Historic Embryology  
1906 Papillary ridges | 1910 Manual of Human Embryology | 1914 Integumentary | 1923 Head Subcutaneous Plexus | 1921 Text-Book of Embryology | 1924 Developmental Anatomy | 1941 Skin Sensory | Historic Disclaimer



Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, et al. (2016) A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet 12(7): e1006150. doi:10.1371/journal.pgen.1006150


This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Fig 7. doi:10.1371/journal.pgen.1006150.g007

Cite this page: Hill, M.A. (2019, August 26) Embryology Integumentary touch dome model 03.jpg. Retrieved from

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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