File:Integumentary touch dome model 01.jpg
Model for developmental signaling requirements for touch dome Merkel cell production
The touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs).
(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.
Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, et al. (2016) A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet 12(7): e1006150. doi:10.1371/journal.pgen.1006150
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Fig 7. doi:10.1371/journal.pgen.1006150.g007
Cite this page: Hill, M.A. (2019, February 18) Embryology Integumentary touch dome model 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Integumentary_touch_dome_model_01.jpg
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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