File:Inner ear haircells.jpg

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Anatomical details of inner ear

The cochlea and organ of Corti, the sense organ of mammalian hearing.

(a) The cochlea, a fluid-filled tripartite channel, is located in the inner ear

(b) A hemisected cochlea provides a radial view of the organ of Corti, a cellular matrix showing the location of hair cells. The input organelles of hair cells, the stereocilia, are connected by different links, including tip-link proteins allowing movement as a unit.

(c) Deflection of the stereocilary bundle due to displacement between the top of the organ of Corti and the bottom of the tectorial membrane provides tension to the tip link, which, in turn, modulates the cation-selective mechanoelectrical transduction (MET) channel's open probability.

(d) The tip link is partially composed of cdh23, which is presumed to interact with the MET channel either directly or indirectly.


Legend

  • IHC - inner hair cell
  • OHC - outer hair cell
  • Myo1c - myosin 1c
  • CaM - calmodulin


Links: inner ear

Reference

Zheng J, Anderson CT, Miller KK, Cheatham M & Dallos P. (2009). Identifying components of the hair-cell interactome involved in cochlear amplification. BMC Genomics , 10, 127. PMID: 19320974 DOI.

Copyright

© 2009 Zheng et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Original image name: 1471-2164-10-127-1-l.jpg Images in (c) and (d) are modified from LeMasurier and Gillespie PMID 16269359.


Cite this page: Hill, M.A. (2019, March 23) Embryology Inner ear haircells.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Inner_ear_haircells.jpg

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current13:56, 5 October 2011Thumbnail for version as of 13:56, 5 October 2011800 × 671 (121 KB)S8600021 (talk | contribs)
01:59, 28 September 2009Thumbnail for version as of 01:59, 28 September 2009600 × 510 (45 KB)S8600021 (talk | contribs)Anatomical details of inner ear, cochlea and organ of Corti, the sense organ of mammalian hearing. The cochlea, a fluid-filled tripartite channel, is located in the inner ear (a). A hemisected cochlea provides a radial view of the organ of Corti, a cell
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