File:Human developing lung protein 01.jpg

Human developing lung protein

Immunohistochemistry studies assessed glutathione S-transferase, C-terminal domain containing (GSTCD) and integrator complex subunit 12 (INTS12) protein expression in tissue sections from controls, individuals with COPD and from a range of fetal developmental stages. All images x40 magnification.

• A: Representative images of GSTCD expression in lung tissue from three healthy donors (images a and e) with matched isotype controls (iso, images c and g) and in lung tissue from three donors with COPD (images b and f) with matched isotype controls (iso, images d and h).
• B: Representative images of INTS12 expression in lung tissue from three control donors (images a and e) with matched isotype controls (iso, images c and g) and in lung tissue from three donors with COPD (images b and f) with matched isotype controls (iso, images d and h).
• C: Panel 1: GSTCD expression in tissue from human fetuses at a range of developmental stages: embryonic (19 days, a and b; 21 days, c and d; 23 days, e and f); pseudoglandular (10 weeks, g and h; 12 weeks, i and j); canalicular (17 weeks, k; 19 weeks, l). Expression was observed to be increased through the pseudoglandular stage. Panel 2: INTS12 expression in the same panel of tissue samples as described above. Isotype controls were all negative (data not shown).

Reference

<pubmed>24058608</pubmed>| PMC3776747 | PLoS One.

Copyright

© 2013 Obeidat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation: Obeidat M, Miller S, Probert K, Billington CK, Henry AP, et al. (2013) GSTCD and INTS12 Regulation and Expression in the Human Lung. PLoS ONE 8(9): e74630. doi:10.1371/journal.pone.0074630

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