File:Fragile X protein cartoon.jpg

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Fragile X Protein Model

Alternative splicing of the primary transcripts generates either ISO6 FMRP lacking the CRD domain, or ISO1 FMRP containing both NLS and CRD domains.

ISO6 is driven to Cajal bodies by transporter proteins, while ISO1 interacts with protein partners that lock the NLS and CRD domains and is localized to the perinuclear area to join the nascent mRNPs complexes emerging from the nuclear pores.

In the cytoplasm the ISO1 FMRP-mRNPs particles associate with the translation machinery or are transported in RNA-granules to micro-domains away from the soma.

Links: Image - FMRP and Cahal bodies | FMRP model | Fragile X Syndrome | Cajal

Historic Embryology - Genital
General: 1901 Urinogenital Tract \| 1902 The Uro-Genital System \| 1904 Ovary and Testis \| 1912 Urinogenital Organ Development \| 1914 External Genitalia \| 1921 Urogenital Development \| 1921 External Genital \| 1942 Sex Cords \| 1953 Germ Cells \| Historic Embryology Papers \| Historic Disclaimer
Female: 1904 Ovary and Testis \| 1904 Hymen \| 1912 Urinogenital Organ Development \| 1914 External Genitalia \| 1914 Female \| 1921 External Genital \| 1927 Female Foetus 15 cm \| 1927 Vagina \| 1932 Postnatal Ovary
Male: 1887-88 Testis \| 1904 Ovary and Testis \| 1904 Leydig Cells \| 1906 Testis vascular \| 1909 Prostate \| 1912 Prostate \| 1914 External Genitalia \| 1915 Cowper’s and Bartholin’s Glands \| 1920 Wolffian tubules \| 1935 Prepuce \| 1935 Wolffian Duct \| 1942 Sex Cords \| 1943 Testes Descent \| Historic Embryology Papers \| Historic Disclaimer

Human Chromosomes: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | X | Y

Reference

Dury AY, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P & Khandjian EW. (2013). Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. PLoS Genet. , 9, e1003890. PMID: 24204304 DOI.

Copyright

© 2013 Dury et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 10 doi:10.1371/journal.pgen.1003890.g010 panel B cropped from full figure. Resized and relabelled.

Cite this page: Hill, M.A. (2024, April 25) Embryology Fragile X protein cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Fragile_X_protein_cartoon.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	10:05, 15 August 2014		1,000 × 615 (107 KB)	Z8600021 (talk \| contribs)	===Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies=== PLoS Genet. 2013 Oct;9(10):e1003890. doi: 10.1371/journal.pgen.1003890. Epub 2013 Oct 31. Dury AY1, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P, Khandjian EW....

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