File:Folate one-carbon metabolism.jpg

Folate one-carbon metabolism

Summary of folate one-carbon metabolism showing the main pathways and reactions that have been subject to analysis in the context of NTDs. For clarity, mitochondrial reactions that include generation of formate and cleavage of glycine have been omitted.

• Blue shading: proteins involved in processing of folates in the digestive tract, transport and cellular retention (by addition of glutamates).
• Yellow shading: the major part of the cycle involving transfer of 1C groups between folate molecules, as required for purine and pyrimidine biosynthesis.
• Pink shading: reactions of the methylation cycle.

Links: Folic Acid and Neural Tube Defects

Reference

Greene ND, Stanier P & Copp AJ. (2009). Genetics of human neural tube defects. Hum. Mol. Genet. , 18, R113-29. PMID: 19808787 DOI.

Copyright

© 2009 Greene ND, Stanier P, Copp AJ. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 1. http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113/DDP347F1

Cite this page: Hill, M.A. (2024, April 16) Embryology Folate one-carbon metabolism.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Folate_one-carbon_metabolism.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G