Development of the genital tubercle and urethral epithelium in the absence of endodermal Fgfr2.

Description

Development of the genital tubercle and urethral epithelium in the absence of endodermal Fgfr2. (A-D) SEM analysis shows that Fgfr2EndoΔ mutants develop abnormal proximal urethral openings (C and D are higher magnification views of boxes in A and B, respectively), but properly patterned preputial swellings (ps), labioscrotal swellings (ls) and urethral seams (arrowheads). (E-H) Histological sections of mutant and control genital tubercles show that the proximal urethra (G,H) forms a urethral lumen, whereas the distal urethra (E,F) remains a bilaminar plate at E14.5. (I,J) Immunohistochemical analysis of K14 on β-Gal-stained sections reveals a thin urethral epithelium in Fgfr2EndoΔ mutants and absence of EMT. (K-L′) Whole-mount X-Gal-staining of β-Gal-expressing endoderm at E14.5 shows reduction of urorectal septum (URS) invasion into Fgfr2EndoΔ mutant genital tubercle relative to controls. Scale bars: 50 μm.
Mark Hill (talk) 16:49, 1 November 2016 (AEDT) Reference and student template included. Wrong copyright statement APS not for Development. Development does allow "Use for bona fide teaching is allowed on the condition that it is non-commercial." http://dev.biologists.org/content/rights-permissions so I will allow this ion the project page unless requested to remove.

Reference

<pubmed>26081573 </pubmed>

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