File:DevelopmentEye-PMC43029243.jpg

PMC4302924

Image Title

Stages of lens formation in mouse embryos Schematics showing the stages of lens development at various points during mouse embryogenesis. (A) E9.0, prospective lens ectoderm. (B) E9.5, lens placode. (C) E10, invaginating lens placode. (D) E10.5, invaginating lens placode to lens pit. (E) E11, open lens vesicle. (F) E12.5, primary lens fiber cell differentiation. (G) E13.5-E14.5, completion of primary lens fiber cell elongation to secondary lens fiber cell formation. (H) Lens growth and secondary lens fiber cell differentiation in adult ocular lens. The apical-basal polarity of lens epithelial and fiber cells is indicated. The area where the apical tips of elongating epithelial cells at the equator constrict to form an anchor point before fiber cell differentiation and elongation at the equator was recently named the ‘lens fulcrum' (Sugiyama et al., 2009). ALE, anterior lens epithelium; CE, corneal epithelium; iLP, invaginating lens placode; iLP/p, invaginating lens placode/lens pit; LC, lens capsule; Epi, lens epithelium; LP, lens placode; NR, neuroretina; OV, optic vesicle; POM, periocular mesenchyme; 1° and 2° LFs, primary and secondary lens fibers; PLE, prospective lens ectoderm; RPE, retinal pigmented epithelium; SE, surface ectoderm.

Image Reference

<pubmed>25406393</pubmed> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302924/

Image Copyright

Copyright © 2014. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Student Image

Note - This image was originally uploaded as part of an undergraduate science student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.