File:Chemical physiological phenotype of nociceptors.JPG

The development of chemical and physiological phenotypes occurs via both intrinsic and extrinsic mechanisms. Intrinsically, nociceptors can express some level of neuropeptides such as Substance P (SP) and calcitonin gene-related peptide (CGRP). Contact with epidermal cells (extrinsic cues) increases this neuropeptide expression. Development of physiological phenotype involves expression of Nav1.8 and TRVP1 in response to neurotrophins.

This is a student drawn diagram by z3332863, based on information from:

Kelvin Y Kwan, Andrew J Allchorne, Melissa A Vollrath, Adam P Christensen, Duan-Sun Zhang, Clifford J Woolf, David P Corey TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron: 2006, 50(2);277-89 PMID:16630838

S C Benn, M Costigan, S Tate, M Fitzgerald, C J Woolf Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons. J. Neurosci.: 2001, 21(16);6077-85 PMID:11487631

A K Hall, X Ai, G E Hickman, S E MacPhedran, C O Nduaguba, C P Robertson The generation of neuronal heterogeneity in a rat sensory ganglion. J. Neurosci.: 1997, 17(8);2775-84 PMID:9092599

O Taherzadeh, W R Otto, U Anand, J Nanchahal, P Anand Influence of human skin injury on regeneration of sensory neurons. Cell Tissue Res.: 2003, 312(3);275-80 PMID:12733058

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