File:Blastocyst- TPR53 expression.jpg

Staining of several embryos from 2 couples (1 & 2) with either nonimmune IgG (1A and 2A) or TRP53 antibody (all other embryos).

TRP53 - transformation related protein 53

• transcription factor that induces the expression of a complex transcriptome
• roles in the regulation of the rate of cell-cycle progression and the survival or death of cells
• expression was low in oocytes, the zygote and cleavage stage embryos but showed an approximate 10-fold increase in transcript number at the blastocyst stage.

Two images of each embryo (except 2C) are provided: an equatorial confocal section (confocal) or phase contrast (phase). All confocal images were taken with identical microscope, laser and magnification settings. The position of the inner cell mass is identified by a white arrow where applicable.

The bar is 10 μm, N.A. is not available.

Original file: 1477-7827-5-39-1-l.jpg

<pubmed>17939878</pubmed>

Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts. Chandrakanthan V, Chami O, Stojanov T, O'Neill C. Reprod Biol Endocrinol. 2007 Oct 17;5:39.

Reprod Biol Endocrinol.

Chandrakanthan et al. Reproductive Biology and Endocrinology 2007 5:39 doi:10.1186/1477-7827-5-39

© 2007 Chandrakanthan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.