File:Anderson2016-fig40b.jpg

Fig. 40b. Mouse E11.5 Heart

The images show, in the left hand panel, how at E11.5 the growth of the protrusion from the dorsal wall of the aortic sac (black star in right hand panel of Figure 39) has grown ventrally into the cavity of the distal outflow tract, separating it into the intrapericardial aortic and pulmonary channels. The white arrows show the regressing myocardial border, which remains confluent with the ends of the distal outflow cushions. There is an embryonic aortopulmonary foramen at this stage of development.

Later in day E11.5, as shown in the right hand panel, the protrusion fuses with the ends of the outflow cushions, which themselves have also fused by this stage. The processes of fusion divide the distal outflow tract into the intrapericardial aorta and pulmonary trunk, at the same time closing the embryonic aortopulmonary foramen. By this stage, additional cushions, known as intercalated cushions, have been formed within the intermediate part of the outflow tract (white stars). These cushions were also seen as the violet structures reconstructed in the right panel of Figure 39. Together with the major cushions, they will provide the primordiums for formation of the leaflets of the arterial valves. The cushions within the proximal outflow tract, in contrast, remain unfused at this stage.

Figure Links: 1 Heart tube mouse E8 | 2 Ventricular loop mouse E8 | 3 Heart mouse E10.5 | 4 Atrial component mouse E10.5 | 5 Sinus horns mouse E8.5 | 6 Venous valve mouse E10.5 | 7a Left atrium CS14 | 7b Atrioventricular canal CS14 | 8a Atrioventricular canal mouse E10.5 | 8b Outflow tract mouse E10.5 | 9a Atrioventricular canal CS14 | 9b Right ventricle CS14 | 10 Ventricular septal defect | fig 11a | fig 11b | fig 12a | fig 12b | fig 13a | fig 13b | fig 14 | fig 15a | fig 15b | fig 16a | fig 16b | fig 17a | fig 17b | fig 18 | fig 19 | fig 20 | fig 21 | fig 22 | fig 23 | fig 24a | fig 24b | fig 25a | fig 25b |fig 26a | fig 26b | fig 27a | fig 27b | fig 28a | fig 28b | fig 29a | fig 29b | fig 30 | fig 31 | fig 32a | fig 32b | fig 33a | fig 33b | fig 34a | fig 34b | fig 35a | fig 35b | fig 36 | fig 37 | fig 38 | fig 39a | fig 39b | fig 40a | fig 40b | fig 41a | fig 41b | fig 42a | 42b | 43a Stenotic pulmonary valve | 43b Stenotic aortic valve | fig 44a | fig 44b | fig 45a | fig 45b | fig 46a | fig 46b | fig 47 | fig 48 | fig 49 | fig 50a | fig 50b | Figure Gallery

Reference

Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)

Cite this page: Hill, M.A. (2024, April 16) Embryology Anderson2016-fig40b.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Anderson2016-fig40b.jpg

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