Category:Mouse E12.5

From Embryology

The Embryology pages and media listed below relate to mouse embryonic day E12.5 of development. This staging by "days" relate to in the female presence of a vaginal plug indicating that the mating occurred, see timed pregnancy.

Mouse Stages: E1 | E2.5 | E3.0 | E3.5 | E4.5 | E5.0 | E5.5 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 E4.5 E5.0 E6.0 E7.0 E8.0 E9.0 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868
Otis EM and Brent R. Equivalent ages in mouse and human embryos. (1954) Anat Rec. 120(1):33-63. PMID 13207763

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

Timeline Links: human timeline | mouse timeline | mouse detailed timeline | chicken timeline | rat timeline | Medaka | Category:Timeline



Mouse Links: Introduction | Mouse Stages | Mouse Timeline | Mouse Timeline Detailed | Mouse Estrous Cycle | Mouse Heart | Mouse Knockout | Movie - Cephalic Plexus | Movie - Blastocyst Cdx2 | ANAT2341 Project 2009 | Category:Mouse
Mouse Movies 
Mouse Zygote  
Fertilization 001 icon.jpg
 ‎‎Mouse Fertilisation
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Mouse zygote division icon.jpg
 ‎‎Zygote Mitosis
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Mouse zygote division 02 icon.jpg
 ‎‎Early Division
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Parental genome mix 01 icon.jpg
 ‎‎Parental Genomes
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Mouse blastocyst movie icon.jpg
 ‎‎Mouse Blastocyst
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Mouse Various  
Oocyte Meiosis 01 icon.jpg
 ‎‎Oocyte Meiosis
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DNA bead-induced ectopic polar body-icon.jpg
 ‎‎Ectopic Polar Body
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Mouse spermatozoa mito movie icon.jpg
 ‎‎Male Mitochondria
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Mouse spermatozoa mito movie icon.jpg
 ‎‎Male Mitochondria
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Mouse Blastocyst Cdx2 icon.jpg
 ‎‎Blastocyst Cdx2
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Model embryo to 128 cell stage icon.jpg
 ‎‎Blastocyst Model
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Mouse lipid droplets icon.jpg
‎‎Mouse Lipid Drops
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Somitogenesis 01 icon.jpg
 ‎‎Somitogenesis
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Mouse-melanoblast migration icon.jpg
 ‎‎Mouse Melanoblast
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Mouse limb gene expression icon.jpg
 ‎‎Limb Genes
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Mouse microCT  
Mouse CT E11.5 movie-icon.jpg
 ‎‎Mouse E11.5 CT
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Mouse CT E12.5 sagittal movie.jpg
 ‎‎Mouse E12.5 CT
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Mouse CT E12.5 coronal movie.jpg
 ‎‎Mouse E12.5 CT
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Mouse CT E12.5 axial movie.jpg
 ‎‎Mouse E12.5 Axial
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Mouse embryo E13 microCT icon.jpg
 ‎‎Mouse E13 microCT
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Mouse embryo E14 microCT icon.jpg
 ‎‎Mouse E14 microCT
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Mouse embryo E14 sectioned microCT icon.jpg
 ‎‎Mouse E14 microCT
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Mouse embryo E15 microCT icon.jpg
 ‎‎Mouse E15 microCT
Play | Play
Mouse face microCT icon.jpg
 ‎‎Mouse Face
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Mouse-Cephalic-plexus-11somite 01.jpg
 ‎‎Mouse Head Plexus
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Historic Embryology - Mouse 
1911 Mouse Egg | 1927 Growth | 1927a Gonads 1 | 1927b Gonads 2 | 1928 Gonads 3 | 1932 Gonads 4 | 1962 Oocyte | 2016 Heart

Events

  • Musculoskeletal System - Abdominal wall second body wall region containing myoblasts thicker (780 μm) than the primary body wall (180 μm). Now distinct inner and outer layers of tissue: inner layer shows unidirectional cell orientation; outer layer has no orientation.[1]
  • palate - secondary palatal development begins. E12.5 to E14 grow vertically along the developing tongue.
  • Salivary Gland Development - indentations (clefts) start to form on the surface of the epithelial bud accompanied by alterations in the basement membrane. Clefts separate the primary bud into multiple buds and the epithelium proliferates. The base of the cleft becomes the primordial ductal structure, salivary branchi}}ng morphogenesis is repeated multiple times over the following days.[2]
  • blood - Haematopoietic stem cells (HSCs) appear in the fetal liver.[3]
  • hearing inner ear - organ of Corti progenitor cells exit the cell cycle between E12.5 and E14.5 before the initiation of sensory receptor cell differentiation.[4]
  • tongue - mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region- and stage-specific manner - Nf2cKO mutants had a decreased level of Hippo signalling transcription factor Yes-associated protein (Yap), Yap target genes and cell proliferation anteriorly, while having an increased Yap, Yap target genes and cell proliferation posteriorly, which lead to a tip-pointed and posteriorly widened tongue.[5]


References

  1. Nichol PF, Corliss RF, Yamada S, Shiota K & Saijoh Y. (2012). Muscle patterning in mouse and human abdominal wall development and omphalocele specimens of humans. Anat Rec (Hoboken) , 295, 2129-40. PMID: 22976993 DOI.
  2. Larsen M, Yamada KM & Musselmann K. (2010). Systems analysis of salivary gland development and disease. Wiley Interdiscip Rev Syst Biol Med , 2, 670-82. PMID: 20890964 DOI.
  3. Rybtsov S, Ivanovs A, Zhao S & Medvinsky A. (2016). Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver. Development , 143, 1284-9. PMID: 27095492 DOI.
  4. Kikuchi K & Hilding D. (1965). The development of the organ of Corti in the mouse. Acta Otolaryngol. , 60, 207-22. PMID: 5861504 DOI.
  5. Ishan M, Chen G, Yu W, Wang Z, Giovannini M, Cao X & Liu HX. (2021). Deletion of Nf2 in neural crest-derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region- and stage-specific manner. Cell Prolif , 54, e13144. PMID: 34697858 DOI.

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Pages in category 'Mouse E12.5'

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