Category:Mouse E11.5

From Embryology
Mouse E11.5

This Embryology category shows pages and media related to mouse embryonic day 11.5 E11.5 of development. This staging by "days" relate to in the female presence of a vaginal plug indicating that the mating occurred, see timed pregnancy.

Mouse Stages: E1 | E2.5 | E3 | E3.5 | E4.5 | E5.0 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 4 5.0 6.0 7.0 8.0 9.0 9.5 E10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

mouse

Events

  • Musculoskeletal System - Abdominal wall secondary development started. Myoblasts migrate ventrally into the primary body wall ventrally about half of the distance to the ventral midline, myoblasts have not yet formed separate inner and outer layers. Lateral plate mesoderm adjacent to the migrating myoblasts thicker and more compact than the lateral plate mesoderm of the more ventral primary abdominal wall.[1]
  • Salivary Gland Development - thickening of the primitive oral epithelium that grows into the first branchial (mandibular) arch mesenchyme to form the solid epithelial placode.[2]
  • Genital System Development - between E11 to E12 gonad differentiates from a bipotential to sexually-differentiated state, based upon transcriptome analysis.[3]
    • Male - somatic cells of XY genital ridges Sry expression reaches a peak
    • Testis vasularization - mesonephric endothelial cells, due to the accumulation in the testis of chemotactic signals, start to migrate through the gonad towards the coelomic domain.[4]
    • External Genital - pair of genital swellings merge to form the single genital tubercle.
  • Thymus Development - Foxn1 (forkhead box N1) expression in the thymus domain of third pouch.[5]
  • Inner Ear Development - Sox2 becomes a prosensory marker within the organ of Corti.[6]

References

  1. Nichol PF, Corliss RF, Yamada S, Shiota K & Saijoh Y. (2012). Muscle patterning in mouse and human abdominal wall development and omphalocele specimens of humans. Anat Rec (Hoboken) , 295, 2129-40. PMID: 22976993 DOI.
  2. Larsen M, Yamada KM & Musselmann K. (2010). Systems analysis of salivary gland development and disease. Wiley Interdiscip Rev Syst Biol Med , 2, 670-82. PMID: 20890964 DOI.
  3. Munger SC, Natarajan A, Looger LL, Ohler U & Capel B. (2013). Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. PLoS Genet. , 9, e1003630. PMID: 23874228 DOI.
  4. Caruso M, Ferranti F, Corano Scheri K, Dobrowolny G, Ciccarone F, Grammatico P, Catizone A & Ricci G. (2015). R-spondin 1/dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis. PLoS ONE , 10, e0124213. PMID: 25910078 DOI.
  5. Blackburn CC & Manley NR. (2004). Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. , 4, 278-89. PMID: 15057786 DOI.
  6. Gu R, Brown RM, Hsu CW, Cai T, Crowder AL, Piazza VG, Vadakkan TJ, Dickinson ME & Groves AK. (2016). Lineage tracing of Sox2-expressing progenitor cells in the mouse inner ear reveals a broad contribution to non-sensory tissues and insights into the origin of the organ of Corti. Dev. Biol. , 414, 72-84. PMID: 27090805 DOI.



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