2017ANAT2341 Tutorial 2

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Introduction

Dr Mark Hill

I am offering a voluntary second tutorial session on Thur 7th September 11 AM - Scenario room G10

This is a voluntary tutorial session and attendance is not compulsory. Notice of this tutorial will be also on the Moodle Course Announcements.

The tutorial will be an opportunity for students to ask any questions you may have about the content within the next 3 online lectures. Please feel free to post any questions or content you would like covered to Moodle.

Online Lectures

Gastrointestinal Development

Endoderm - Gastrointestinal Tract

Lecture Objectives

  • Understanding of germ layer contributions to the early gastrointestinal tract (GIT)
  • Understanding of the folding of the GIT
  • Understanding of three main GIT embryonic divisions
  • Understanding of associated organ development (liver, pancreas, spleen)
  • Brief understanding of mechanical changes (rotations) during GIT development
  • Brief understanding of gastrointestinal abnormalities


Germ Layer Contributions
  • Endoderm - epithelium and associated glands.
  • Mesoderm (splanchnic) - mesentry, connective tissues, smooth muscle, blood vessels.
  • Ectoderm (neural crest) - enteric nervous system.
Mesoderm-cartoon4.jpg

endoderm, Splanchnic mesoderm and Intra-embryonic coelom

Cardiovascular Development

Cardiovascular - Heart

Lecture Objectives

  • Understanding of early blood vessel and blood development
    • Brief understanding of vascular growth and regression
    • Brief understanding of vascular growth factors
  • Understanding of heart development
    • Understanding of heart timeline
    • Understanding of heart septation

Intermediate Heart Development Timeline.jpg

Begin Intermediate: Primordial Heart Tube  Heart Tube Looping  Atrial Ventricular Septation  Outflow Tract  Heart Valves  Cardiac Abnormalities  Vascular Overview

Neural Crest Development

Neural Crest

Lecture Objectives

  • Understand the structures derived from ectoderm.
  • Identify the initial location of neural crest cells and pathways of neural crest migration throughout the embryo.
  • To know the major tissues to which neural crest cells contribute.
  • To know how abnormalities associated with neural crest cell.

Neural crest contribution.jpg


Neural Crest Origin
System Cell Type
Peripheral Nervous System
(PNS)
Neurons - sensory ganglia, sympathetic and parasympathetic ganglia, enteric nervous system, and plexuses

Neuroglial cells, olfactory ensheathing cells[1]

Schwann cells[2]

Endocrine Adrenal medulla
Calcitonin-secreting cells
Carotid body type I cells
Integumentary Epidermal pigment cells
Facial cartilage and bone Facial and anterior ventral skull cartilage and bones
Sensory Inner ear, corneal endothelium and stroma
Connective tissue Tooth papillae

smooth muscle, and adipose tissue of skin of head and neck

Connective tissue of meninges, salivary, lachrymal, thymus, thyroid, and pituitary glands

Connective tissue and smooth muscle in arteries of aortic arch origin

Links: Neural Crest Development | Category:Neural Crest | Neural Crest collapsible table

Next

I will provide a third tutorial after the next batch of online lectures (14, 16, 18) have been covered. Please use the online forum to post any questions or content that you would like discussed.


  1. Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ & Baker CV. (2010). Neural crest origin of olfactory ensheathing glia. Proc. Natl. Acad. Sci. U.S.A. , 107, 21040-5. PMID: 21078992 DOI.
  2. Woodhoo A & Sommer L. (2008). Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. Glia , 56, 1481-90. PMID: 18803317 DOI.


 2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3

Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 Genetic Disorders | 10 Melanocytes | 11 Stem Cells | 12 Group

Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision

 Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum