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		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=161213</id>
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		<updated>2014-10-29T00:09:26Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab Attendance */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
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Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
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Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
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Lab 10 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:09, 15 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 11 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:43, 22 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 12 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 29 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
&lt;br /&gt;
==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
&lt;br /&gt;
==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
Microarray Analysis&lt;br /&gt;
&lt;br /&gt;
Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
&lt;br /&gt;
Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
&lt;br /&gt;
Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;br /&gt;
&lt;br /&gt;
'''Group 1'''&lt;br /&gt;
&lt;br /&gt;
* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
&lt;br /&gt;
* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
&lt;br /&gt;
* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
	&lt;br /&gt;
* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
	&lt;br /&gt;
* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
	&lt;br /&gt;
* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
	&lt;br /&gt;
* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
	&lt;br /&gt;
* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
&lt;br /&gt;
* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
&lt;br /&gt;
* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
&lt;br /&gt;
'''Group 2'''&lt;br /&gt;
&lt;br /&gt;
* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
&lt;br /&gt;
* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
&lt;br /&gt;
* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
&lt;br /&gt;
* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
&lt;br /&gt;
* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
&lt;br /&gt;
* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
&lt;br /&gt;
* I insist for you to put all the references in one place.&lt;br /&gt;
&lt;br /&gt;
* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
&lt;br /&gt;
'''Group 4'''&lt;br /&gt;
&lt;br /&gt;
* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
&lt;br /&gt;
* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
&lt;br /&gt;
* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
&lt;br /&gt;
* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
&lt;br /&gt;
* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
&lt;br /&gt;
* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
&lt;br /&gt;
* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 5'''&lt;br /&gt;
&lt;br /&gt;
* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
&lt;br /&gt;
* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
&lt;br /&gt;
* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
&lt;br /&gt;
* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
&lt;br /&gt;
* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
&lt;br /&gt;
* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
&lt;br /&gt;
* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
&lt;br /&gt;
* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
&lt;br /&gt;
* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 6'''&lt;br /&gt;
&lt;br /&gt;
* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
&lt;br /&gt;
* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
&lt;br /&gt;
* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
&lt;br /&gt;
* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
&lt;br /&gt;
* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
&lt;br /&gt;
* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
&lt;br /&gt;
* Thymus section only has little information so work more on this.&lt;br /&gt;
&lt;br /&gt;
* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
&lt;br /&gt;
* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
&lt;br /&gt;
* Gonad development section is well presented just add images to it. &lt;br /&gt;
&lt;br /&gt;
* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
&lt;br /&gt;
* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
&lt;br /&gt;
* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
&lt;br /&gt;
* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 7'''&lt;br /&gt;
&lt;br /&gt;
* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
&lt;br /&gt;
* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
&lt;br /&gt;
* Brain development section has a very good table and an image. &lt;br /&gt;
&lt;br /&gt;
* Spinal cord development section needs more information.&lt;br /&gt;
&lt;br /&gt;
* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
&lt;br /&gt;
* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
&lt;br /&gt;
* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
&lt;br /&gt;
* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 8'''&lt;br /&gt;
&lt;br /&gt;
* “Making Gains” is pretty funny but offcourse irrelevant to this project. &lt;br /&gt;
&lt;br /&gt;
* Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
&lt;br /&gt;
* Background embryonic development section is well detailed though it lacks images to aid the information.  Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images. &lt;br /&gt;
&lt;br /&gt;
* Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references.  The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;br /&gt;
&lt;br /&gt;
===Lab 10===&lt;br /&gt;
&lt;br /&gt;
'''Identify a recent research paper on sensory development (not hearing) and write a brief summary (several paragraphs) of the research methods and findings. Include at the end a link to the relevant wiki sensory notes page.'''&lt;br /&gt;
&lt;br /&gt;
All procedures were approved by the Ethics Commission of the Faculty of Medicine of the University of Coimbra in this study. Written consent was obtained from participants older than 18 years old. Only one eye was evaluated under monocular conditions in a dark room.&lt;br /&gt;
&lt;br /&gt;
A total of 123 participants were considered for the intermediate spatial/null temporal frequency channel. For low spatial/null temporal frequency channel, a total of 135 participants were used. All participants were volunteers. All participants were examined via a complete neuro-ophthalmological examination. This exam included best corrected visual acuity (VA) which was obtained by Snellen chart, ocular tension, slit lamp biomicroscopy and fundus examination.  All participants were right handed, had normal or corrected to normal visual acuity and were naive to the true purpose of the examinations being performed. &lt;br /&gt;
&lt;br /&gt;
For intermediate spatial/null temporal frequency channel, achromatic contrast sensitivity was measured. The stimuli were static vertical gratings with spatial frequency of 3.5 cpd and were displayed on a 21-in. The stimulus, size and locations were all tested within the visual field. Psychophysical thresholds were obtained using an adaptive logarithmic staircase strategy. The staircases were run for a total of four reversals which was measured in decibels. In another task, detection targets in multiple locations of visual fields were used as stimuli. The subjects’ responses were recorded with millisecond resolution. &lt;br /&gt;
&lt;br /&gt;
For low spatial/null temporal frequency channel the stimuli were sinusoidal vertical gratings with low spatial frequency. Testing with or without ramp does not change the spatial pattern of CS asymmetry results. &lt;br /&gt;
&lt;br /&gt;
For both intermediate and low spatial/null temporal frequency channel, the results were via the examination of the anisotropy of contrast sensitivity between hemifields in development cohorts. Analysis of global patterns of left/right visual hemifield asymmetry were done using intermediate spatial frequency/static stimuli. &lt;br /&gt;
&lt;br /&gt;
The overall results illustrated that interhemispheric (left/right visual hemifield) asymmetries were present in the early life during childhood and adulthood, but only for the intermediate spatial frequency channel.  The right hemisphere dominance which is recognised for high level visual processing, can also hold true concerning low level spatial vision. The left visual hemifield advantage was found to be from childhood to adulthood. &lt;br /&gt;
&lt;br /&gt;
''Reference''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25326605&amp;lt;/pubmed&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=160574</id>
		<title>User:Z3414515</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=160574"/>
		<updated>2014-10-24T15:00:33Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab 9 */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 10 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:09, 15 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 11 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:43, 22 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
&lt;br /&gt;
==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
&lt;br /&gt;
==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
Microarray Analysis&lt;br /&gt;
&lt;br /&gt;
Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
&lt;br /&gt;
Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
&lt;br /&gt;
Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;br /&gt;
&lt;br /&gt;
'''Group 1'''&lt;br /&gt;
&lt;br /&gt;
* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
&lt;br /&gt;
* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
&lt;br /&gt;
* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
	&lt;br /&gt;
* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
	&lt;br /&gt;
* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
	&lt;br /&gt;
* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
	&lt;br /&gt;
* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
	&lt;br /&gt;
* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
&lt;br /&gt;
* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
&lt;br /&gt;
* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
&lt;br /&gt;
'''Group 2'''&lt;br /&gt;
&lt;br /&gt;
* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
&lt;br /&gt;
* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
&lt;br /&gt;
* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
&lt;br /&gt;
* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
&lt;br /&gt;
* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
&lt;br /&gt;
* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
&lt;br /&gt;
* I insist for you to put all the references in one place.&lt;br /&gt;
&lt;br /&gt;
* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
&lt;br /&gt;
'''Group 4'''&lt;br /&gt;
&lt;br /&gt;
* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
&lt;br /&gt;
* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
&lt;br /&gt;
* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
&lt;br /&gt;
* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
&lt;br /&gt;
* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
&lt;br /&gt;
* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
&lt;br /&gt;
* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 5'''&lt;br /&gt;
&lt;br /&gt;
* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
&lt;br /&gt;
* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
&lt;br /&gt;
* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
&lt;br /&gt;
* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
&lt;br /&gt;
* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
&lt;br /&gt;
* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
&lt;br /&gt;
* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
&lt;br /&gt;
* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
&lt;br /&gt;
* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 6'''&lt;br /&gt;
&lt;br /&gt;
* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
&lt;br /&gt;
* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
&lt;br /&gt;
* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
&lt;br /&gt;
* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
&lt;br /&gt;
* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
&lt;br /&gt;
* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
&lt;br /&gt;
* Thymus section only has little information so work more on this.&lt;br /&gt;
&lt;br /&gt;
* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
&lt;br /&gt;
* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
&lt;br /&gt;
* Gonad development section is well presented just add images to it. &lt;br /&gt;
&lt;br /&gt;
* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
&lt;br /&gt;
* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
&lt;br /&gt;
* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
&lt;br /&gt;
* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 7'''&lt;br /&gt;
&lt;br /&gt;
* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
&lt;br /&gt;
* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
&lt;br /&gt;
* Brain development section has a very good table and an image. &lt;br /&gt;
&lt;br /&gt;
* Spinal cord development section needs more information.&lt;br /&gt;
&lt;br /&gt;
* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
&lt;br /&gt;
* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
&lt;br /&gt;
* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
&lt;br /&gt;
* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 8'''&lt;br /&gt;
&lt;br /&gt;
* “Making Gains” is pretty funny but offcourse irrelevant to this project. &lt;br /&gt;
&lt;br /&gt;
* Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
&lt;br /&gt;
* Background embryonic development section is well detailed though it lacks images to aid the information.  Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images. &lt;br /&gt;
&lt;br /&gt;
* Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references.  The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;br /&gt;
&lt;br /&gt;
===Lab 10===&lt;br /&gt;
&lt;br /&gt;
'''Identify a recent research paper on sensory development (not hearing) and write a brief summary (several paragraphs) of the research methods and findings. Include at the end a link to the relevant wiki sensory notes page.'''&lt;br /&gt;
&lt;br /&gt;
All procedures were approved by the Ethics Commission of the Faculty of Medicine of the University of Coimbra in this study. Written consent was obtained from participants older than 18 years old. Only one eye was evaluated under monocular conditions in a dark room.&lt;br /&gt;
&lt;br /&gt;
A total of 123 participants were considered for the intermediate spatial/null temporal frequency channel. For low spatial/null temporal frequency channel, a total of 135 participants were used. All participants were volunteers. All participants were examined via a complete neuro-ophthalmological examination. This exam included best corrected visual acuity (VA) which was obtained by Snellen chart, ocular tension, slit lamp biomicroscopy and fundus examination.  All participants were right handed, had normal or corrected to normal visual acuity and were naive to the true purpose of the examinations being performed. &lt;br /&gt;
&lt;br /&gt;
For intermediate spatial/null temporal frequency channel, achromatic contrast sensitivity was measured. The stimuli were static vertical gratings with spatial frequency of 3.5 cpd and were displayed on a 21-in. The stimulus, size and locations were all tested within the visual field. Psychophysical thresholds were obtained using an adaptive logarithmic staircase strategy. The staircases were run for a total of four reversals which was measured in decibels. In another task, detection targets in multiple locations of visual fields were used as stimuli. The subjects’ responses were recorded with millisecond resolution. &lt;br /&gt;
&lt;br /&gt;
For low spatial/null temporal frequency channel the stimuli were sinusoidal vertical gratings with low spatial frequency. Testing with or without ramp does not change the spatial pattern of CS asymmetry results. &lt;br /&gt;
&lt;br /&gt;
For both intermediate and low spatial/null temporal frequency channel, the results were via the examination of the anisotropy of contrast sensitivity between hemifields in development cohorts. Analysis of global patterns of left/right visual hemifield asymmetry were done using intermediate spatial frequency/static stimuli. &lt;br /&gt;
&lt;br /&gt;
The overall results illustrated that interhemispheric (left/right visual hemifield) asymmetries were present in the early life during childhood and adulthood, but only for the intermediate spatial frequency channel.  The right hemisphere dominance which is recognised for high level visual processing, can also hold true concerning low level spatial vision. The left visual hemifield advantage was found to be from childhood to adulthood. &lt;br /&gt;
&lt;br /&gt;
''Reference''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25326605&amp;lt;/pubmed&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=160571</id>
		<title>User:Z3414515</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=160571"/>
		<updated>2014-10-24T14:54:23Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab 9 */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
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Lab 10 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:09, 15 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 11 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:43, 22 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
&lt;br /&gt;
==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
&lt;br /&gt;
==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
Microarray Analysis&lt;br /&gt;
&lt;br /&gt;
Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
&lt;br /&gt;
Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
&lt;br /&gt;
Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;br /&gt;
&lt;br /&gt;
'''Group 1'''&lt;br /&gt;
&lt;br /&gt;
* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
&lt;br /&gt;
* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
&lt;br /&gt;
* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
	&lt;br /&gt;
* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
	&lt;br /&gt;
* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
	&lt;br /&gt;
* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
	&lt;br /&gt;
* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
	&lt;br /&gt;
* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
&lt;br /&gt;
* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
&lt;br /&gt;
* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
&lt;br /&gt;
'''Group 2'''&lt;br /&gt;
&lt;br /&gt;
* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
&lt;br /&gt;
* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
&lt;br /&gt;
* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
&lt;br /&gt;
* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
&lt;br /&gt;
* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
&lt;br /&gt;
* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
&lt;br /&gt;
* I insist for you to put all the references in one place.&lt;br /&gt;
&lt;br /&gt;
* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
&lt;br /&gt;
'''Group 4'''&lt;br /&gt;
&lt;br /&gt;
* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
&lt;br /&gt;
* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
&lt;br /&gt;
* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
&lt;br /&gt;
* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
&lt;br /&gt;
* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
&lt;br /&gt;
* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
&lt;br /&gt;
* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 5'''&lt;br /&gt;
&lt;br /&gt;
* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
&lt;br /&gt;
* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
&lt;br /&gt;
* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
&lt;br /&gt;
* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
&lt;br /&gt;
* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
&lt;br /&gt;
* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
&lt;br /&gt;
* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
&lt;br /&gt;
* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
&lt;br /&gt;
* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 6'''&lt;br /&gt;
&lt;br /&gt;
* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
&lt;br /&gt;
* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
&lt;br /&gt;
* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
&lt;br /&gt;
* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
&lt;br /&gt;
* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
&lt;br /&gt;
* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
&lt;br /&gt;
* Thymus section only has little information so work more on this.&lt;br /&gt;
&lt;br /&gt;
* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
&lt;br /&gt;
* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
&lt;br /&gt;
* Gonad development section is well presented just add images to it. &lt;br /&gt;
&lt;br /&gt;
* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
&lt;br /&gt;
* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
&lt;br /&gt;
* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
&lt;br /&gt;
* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 7'''&lt;br /&gt;
&lt;br /&gt;
* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
&lt;br /&gt;
* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
&lt;br /&gt;
* Brain development section has a very good table and an image. &lt;br /&gt;
&lt;br /&gt;
* Spinal cord development section needs more information.&lt;br /&gt;
&lt;br /&gt;
* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
&lt;br /&gt;
* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
&lt;br /&gt;
* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
&lt;br /&gt;
* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 8'''&lt;br /&gt;
&lt;br /&gt;
* “Making Gains” is pretty funny but offcourse irrelevant to this project. &lt;br /&gt;
&lt;br /&gt;
* Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
&lt;br /&gt;
* Background embryonic development section is well detailed though it lacks images to aid the information.  Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images. &lt;br /&gt;
&lt;br /&gt;
* Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references.  The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=160259</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=160259"/>
		<updated>2014-10-24T09:30:36Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Discussion */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014discussionheader}}&lt;br /&gt;
==Peer Reviews==&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! Reviews&lt;br /&gt;
|- &lt;br /&gt;
| A nice overview is presented for basic information to be presented onto the project page, with a descriptive introduction into the topic of GIT. Perhaps this section could include a brief mention of the aims of the page and perhaps a few images to make it more visually appealing. Timeline section is particularly extensive, however perhaps the layout can be altered- either adding further information to each developmental stage or even using a table format with images to aid the readers understanding of the processes. The subheadings of this section were also a particularly nice way to structure the information. Recent findings needs a bit more work- perhaps a particular focus could be established for this section of even links to a few articles organised by research into particular organs of the GIT. A few images would also increase the visual appeal to this section. The main body of information (foregut, midgut and hind-gut) are well covered and written- there is evidence of extensive research and work put into this section. The hand drawing idea was also particularly a good idea also with a proper description added to the image. Formatting to this section could be a little more unified however as some section use different styles of bullet points and ways to present the information. Deformities section is greatly informative; perhaps a few more should be presented with accompanying images. The overall references section was formatted correctly. &lt;br /&gt;
&lt;br /&gt;
-----&lt;br /&gt;
&lt;br /&gt;
*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I can not find a ‘historical findings’ section? &lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST)&lt;br /&gt;
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We need to find recent research articles on stem cell on this weekend people. By this friday night please try to finish your section of this project so on the weekends we can focus on current models/findings and historical findings. Thanks group :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:00, 15 October 2014 (EST)&lt;br /&gt;
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I didn't like having to get through all the peer reviews to get to discussion. I collapsed it for ease of use --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 11:51, 19 October 2014 (EST)&lt;br /&gt;
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well done z3375627 for collapsing the discussion section. It makes a whole lot easier for us now :) and ALSO thank you z3415242 for doing the timeline table. It looks good but obviously we need to try to add a bit more information on it. Lets get our sections finished first people THEN we can worry about the editing. ALSO do not forgot to contribute a stem cell research paper on the facebook group so we can discuss it. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 16:44, 19 October 2014 (EST)&lt;br /&gt;
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ok so looking through the peer reviews the main things that people were talking about were: make sure that we tabulate our information, add more models and research findings and then there were things more related to the individual assessments. So its good that someone has started to tabulate our timetable but its a bit all over the place at the moment so we probably need to fix it up a bit. and then we really need to get onto the research findings ect.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 19:08, 19 October 2014 (EST)&lt;br /&gt;
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People do not forget to add reference for the image within the image if that makes sense. And we need to finish our part of the project as well as current findings, models and historic finding by tomorrow night or by wednesday lab PLEASEEEEE. This is because we need to spend a day on editing the page overall as a whole with consideration to the peer reviews. ALSO we MUST have a gathering so we can do this editing together either on wednesday after lab OR thursday. THANK YOUUU :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:18, 20 October 2014 (EST)&lt;br /&gt;
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Wednesday would be suitable for me if that is fine with the group also i have added a link of a recent finding under that heading can someone please check its ok to use so then i can start to summarise it, and for the stem cell presentation i have found this http://circ.ahajournals.org/content/125/7/883.long i hope you guys are fine with it. Also does anyone know any good link where i can get xray image or real life image of infant with one of the disease,it's hard finding image which allows permission for use if any of you guys have suggestion would much appreciate it thanks --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 10:17, 20 October 2014 (EST)&lt;br /&gt;
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I cant find a place for x ray images sorry. Just had a look at that article you have under the current research on our page. I think it would be fine to use. I assume you were going to put this under the models section right???--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:00, 20 October 2014 (EST)&lt;br /&gt;
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yes i was thinking that but I'm not sure if it relates with fetal development, i also found this http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009111&lt;br /&gt;
i think can be used for findings so i might sumamrise this first i think its more relevant then my previous link --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 10:45, 21 October 2014 (EST)&lt;br /&gt;
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so i changed the table a bit to simplify it. I will explain tomorrow in class why when you click on some of the links it doesn't work. I worry a bit about the foregut section in the timetable because i feel as though its a bit embryonic heavy. But i think mark will be fine with it anyway. I think you might have said something ealrier about you talking to mark about it so we should be alright. so we just need to finish off the findings part and then make the last few changes and then we should be right.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:54, 22 October 2014 (EST)&lt;br /&gt;
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I noticed that Midgut doesn't have appearance of villi. After gut return, week 9 has differentiation of epithelium in intestines. Week 11 villi appear in SI, with lining complete by week 16. If you don't have the time to add anything, i'll revisit again tomorrow night/Friday morning and add it in --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 23:41, 22 October 2014 (EST)&lt;br /&gt;
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Ok just did it then. Tell me what you think. I also updated it to the timeline. I think our project is coming along well overall. Hopefully mark realises that we are trying to keep things as simple and as interesting as possible and we are not trying to kill the page with too much information. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 18:49, 23 October 2014 (EST)&lt;br /&gt;
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I guys i was just trying to fix some stuff and i was wondering where my abnormality table information went from the coding as without it i can't add information into the table, if anyone edited it could you let me know where the content is so i can fix up the blank boxes thankyou --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 20:59, 23 October 2014 (EST)&lt;br /&gt;
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Yeah, looks good [[User:Z3415141|Z3415141]]. Everything is coming along nicely. I may fiddle with the picture layout in the Midgut section when I edit tomorrow just to make the whole page a little more uniform and condense. If anyone wants anything specificly changed done let me know below, I'll be working on the page until roughly 3-4pm tomorrow  --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 23:01, 23 October 2014 (EST)&lt;br /&gt;
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Getting so frustrated with the images. I hand drawn 3 images which took me awhile and then I couldn't use them due to lack of referencing :( . However I did put up some images which I found recently. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:44, 24 October 2014 (EST)&lt;br /&gt;
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The page looks great people. Good job everyone. I am soo sorry that I could not do anythin today as i was out for an interview and my car got broken down so it had to be towed.--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:30, 24 October 2014 (EST)&lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
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&amp;lt;/gallery&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=158339</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=158339"/>
		<updated>2014-10-23T22:48:36Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
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&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
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=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
[[File:Adult gastrointestinal tract cartoon.jpg|thumb|right|300px| Grown GIT system.]]&lt;br /&gt;
The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
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==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
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! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
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| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 5'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
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'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
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|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
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'''Week 19:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
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|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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'''Xenopus.Laevis model system revealing molecular pathway of gut adaptation from embryo to adult'''&lt;br /&gt;
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The gastrointestinal tract is remodeled from embryo to adult to adapt to changing dietary environment. To study the mammalian gastrointestinal development as well as to determine genes and signalling programs which are important for gut development and maturation the Xenopus.Laevis metamorphosis system became a great model system for use. &lt;br /&gt;
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A change in gene expression during mammalian intestinal maturation and postembryonic development was observed by investigating similarities in gene regulation between X.Laevis and mouse. Both systems have increase T3 level which circulates in the blood stream during the postembryonic development therefore the study focused on genes whose expressions increased with more T3 levels. Genes were therefore ranked based upon their relative expression at stage 61 From this gene expression profiles, 6  major gene clusters which are involved in intestinal transformation from embryo to adult were identified. The two clusters of genes had peaks at around birth in mammals. &amp;lt;ref name=&amp;quot;PMID20482879&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20482879&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;The X.laevis model helped contribute in identifying novel embryonic and adult specific genes providing a better insight of the molecular regulation of GI development as well as its function. 17 embryonic specific and 52 adult specific genes were identified and showed relationship to the development and physiology of the organs of the GIT. For example in mature intestine there is significant increase of PRSS2 and PRSS3 enzymes.&amp;lt;ref name=&amp;quot;PMID20482879&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20482879&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The pancreas was the only organ that showed synthesize of serine proteinases (trypsins) during maturation. The comparative analysis showed  that during mammalian intestinal development genes that peaked at stages 61 were significantly up-regulated at birth in mouse suggesting molecular signatures are highly conserved in more than one species during GI development and that T3 can have potential role of regulating target genes in intestinal development. &lt;br /&gt;
TGF-B signalling pathway was analysed used GenMAPP database and it was seen to have proliferating role in intestinal maturation and cell proliferation. &amp;lt;ref name=&amp;quot;PMID20482879&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20482879&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Overall the gene expression studying with the utilisation of X.Laevis system provided molecular description of maturation and remodelling of the postembryonic developing Gastro intestine improving understanding of intestinal organogenesis as well as the nature of molecular regulation during fetal development. &lt;br /&gt;
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===Current Research===&lt;br /&gt;
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Recent Findings on Omphalocele: (Sonic hedgehog expression in the development of hindgut) &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
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Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
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As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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''For this section some references were from the Moore, KL, Persuad, TVN &amp;amp; Trochia MG. (2011) '''The Developing Human: Clinically Oriented Embryology''' (9th edition). Philadelphia: Saunders''&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
[[File:Histology of human embryonic liver at 11 weeks.png|300px|thumb|right|Histology of human embryonic liver at 11 weeks]]&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
[[File:Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group.png|300px|thumb|right|Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group]]&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
[[File:3–11_SS_caudal_foregut_endoderm.png|200px|thumb|right|3–11 SS caudal foregut endoderm]] &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22815796&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
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Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
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'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
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Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
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Possible cause: &lt;br /&gt;
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The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
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'''Omphalocele'''&lt;br /&gt;
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[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
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Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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[[File:Malrotation.jpg|thumb|right|200px| Reverse rotation: cecum ended up on left side labelled as black asterisk while ascending colon and terminal ileum shown as white asterisk is running to the right side.]]&lt;br /&gt;
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'''Reverse rotation'''&lt;br /&gt;
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Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
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===Anorectal deformities===&lt;br /&gt;
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There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
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-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
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- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
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- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
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'''Cloacal Extrophy'''&lt;br /&gt;
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If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
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'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
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'''Deep deformities:'''&lt;br /&gt;
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•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
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'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
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•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
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'''Hirschsprung disease'''&lt;br /&gt;
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Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
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'''List of research/articles:'''&lt;br /&gt;
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1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=158324</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=158324"/>
		<updated>2014-10-23T22:44:30Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Discussion */&lt;/p&gt;
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==Peer Reviews==&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
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| A nice overview is presented for basic information to be presented onto the project page, with a descriptive introduction into the topic of GIT. Perhaps this section could include a brief mention of the aims of the page and perhaps a few images to make it more visually appealing. Timeline section is particularly extensive, however perhaps the layout can be altered- either adding further information to each developmental stage or even using a table format with images to aid the readers understanding of the processes. The subheadings of this section were also a particularly nice way to structure the information. Recent findings needs a bit more work- perhaps a particular focus could be established for this section of even links to a few articles organised by research into particular organs of the GIT. A few images would also increase the visual appeal to this section. The main body of information (foregut, midgut and hind-gut) are well covered and written- there is evidence of extensive research and work put into this section. The hand drawing idea was also particularly a good idea also with a proper description added to the image. Formatting to this section could be a little more unified however as some section use different styles of bullet points and ways to present the information. Deformities section is greatly informative; perhaps a few more should be presented with accompanying images. The overall references section was formatted correctly. &lt;br /&gt;
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*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I can not find a ‘historical findings’ section? &lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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|}&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST)&lt;br /&gt;
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We need to find recent research articles on stem cell on this weekend people. By this friday night please try to finish your section of this project so on the weekends we can focus on current models/findings and historical findings. Thanks group :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:00, 15 October 2014 (EST)&lt;br /&gt;
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I didn't like having to get through all the peer reviews to get to discussion. I collapsed it for ease of use --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 11:51, 19 October 2014 (EST)&lt;br /&gt;
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well done z3375627 for collapsing the discussion section. It makes a whole lot easier for us now :) and ALSO thank you z3415242 for doing the timeline table. It looks good but obviously we need to try to add a bit more information on it. Lets get our sections finished first people THEN we can worry about the editing. ALSO do not forgot to contribute a stem cell research paper on the facebook group so we can discuss it. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 16:44, 19 October 2014 (EST)&lt;br /&gt;
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ok so looking through the peer reviews the main things that people were talking about were: make sure that we tabulate our information, add more models and research findings and then there were things more related to the individual assessments. So its good that someone has started to tabulate our timetable but its a bit all over the place at the moment so we probably need to fix it up a bit. and then we really need to get onto the research findings ect.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 19:08, 19 October 2014 (EST)&lt;br /&gt;
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People do not forget to add reference for the image within the image if that makes sense. And we need to finish our part of the project as well as current findings, models and historic finding by tomorrow night or by wednesday lab PLEASEEEEE. This is because we need to spend a day on editing the page overall as a whole with consideration to the peer reviews. ALSO we MUST have a gathering so we can do this editing together either on wednesday after lab OR thursday. THANK YOUUU :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:18, 20 October 2014 (EST)&lt;br /&gt;
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Wednesday would be suitable for me if that is fine with the group also i have added a link of a recent finding under that heading can someone please check its ok to use so then i can start to summarise it, and for the stem cell presentation i have found this http://circ.ahajournals.org/content/125/7/883.long i hope you guys are fine with it. Also does anyone know any good link where i can get xray image or real life image of infant with one of the disease,it's hard finding image which allows permission for use if any of you guys have suggestion would much appreciate it thanks --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 10:17, 20 October 2014 (EST)&lt;br /&gt;
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I cant find a place for x ray images sorry. Just had a look at that article you have under the current research on our page. I think it would be fine to use. I assume you were going to put this under the models section right???--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:00, 20 October 2014 (EST)&lt;br /&gt;
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yes i was thinking that but I'm not sure if it relates with fetal development, i also found this http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009111&lt;br /&gt;
i think can be used for findings so i might sumamrise this first i think its more relevant then my previous link --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 10:45, 21 October 2014 (EST)&lt;br /&gt;
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so i changed the table a bit to simplify it. I will explain tomorrow in class why when you click on some of the links it doesn't work. I worry a bit about the foregut section in the timetable because i feel as though its a bit embryonic heavy. But i think mark will be fine with it anyway. I think you might have said something ealrier about you talking to mark about it so we should be alright. so we just need to finish off the findings part and then make the last few changes and then we should be right.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:54, 22 October 2014 (EST)&lt;br /&gt;
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I noticed that Midgut doesn't have appearance of villi. After gut return, week 9 has differentiation of epithelium in intestines. Week 11 villi appear in SI, with lining complete by week 16. If you don't have the time to add anything, i'll revisit again tomorrow night/Friday morning and add it in --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 23:41, 22 October 2014 (EST)&lt;br /&gt;
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Ok just did it then. Tell me what you think. I also updated it to the timeline. I think our project is coming along well overall. Hopefully mark realises that we are trying to keep things as simple and as interesting as possible and we are not trying to kill the page with too much information. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 18:49, 23 October 2014 (EST)&lt;br /&gt;
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I guys i was just trying to fix some stuff and i was wondering where my abnormality table information went from the coding as without it i can't add information into the table, if anyone edited it could you let me know where the content is so i can fix up the blank boxes thankyou --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 20:59, 23 October 2014 (EST)&lt;br /&gt;
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Yeah, looks good [[User:Z3415141|Z3415141]]. Everything is coming along nicely. I may fiddle with the picture layout in the Midgut section when I edit tomorrow just to make the whole page a little more uniform and condense. If anyone wants anything specificly changed done let me know below, I'll be working on the page until roughly 3-4pm tomorrow  --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 23:01, 23 October 2014 (EST)&lt;br /&gt;
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Getting so frustrated with the images. I hand drawn 3 images which took me awhile and then I couldn't use them due to lack of referencing :( . However I did put up some images which I found recently. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:44, 24 October 2014 (EST)&lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
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&amp;lt;/gallery&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157775</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157775"/>
		<updated>2014-10-23T14:51:41Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Liver, Gallbladder and Bile Duct */&lt;/p&gt;
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&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
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=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
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The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
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==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
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! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 5'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
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'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
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|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
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'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
{|&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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{|&lt;br /&gt;
|-bgcolor=&amp;quot;E0 FF FF&amp;quot;&lt;br /&gt;
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===Current Research===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
&lt;br /&gt;
Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
&lt;br /&gt;
As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
&lt;br /&gt;
&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
[[File:Histology of human embryonic liver at 11 weeks.png|300px|thumb|right|Histology of human embryonic liver at 11 weeks]]&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
[[File:Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group.png|300px|thumb|right|Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group]]&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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[[File:3–11_SS_caudal_foregut_endoderm.png|200px|thumb|right|3–11 SS caudal foregut endoderm]] &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22815796&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
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During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
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-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
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-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
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Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
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[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
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|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
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[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
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'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
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===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Malrotation.jpg|thumb|right|200px| Reverse rotation: cecum ended up on left side labelled as black asterisk while ascending colon and terminal ileum shown as white asterisk is running to the right side.]]&lt;br /&gt;
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&lt;br /&gt;
'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
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'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Photomicrographs_of_gallbladder_samples_stained_with_hematoxylin_and_eosin_in_each_group.png&amp;diff=157772</id>
		<title>File:Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group.png</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Photomicrographs_of_gallbladder_samples_stained_with_hematoxylin_and_eosin_in_each_group.png&amp;diff=157772"/>
		<updated>2014-10-23T14:49:16Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: ==Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group==

Photomicrographs magnification are 400x. (a) Shows normal gallbladder histology. (b) CBDL-1 group showing edema, congestion and inflammatory cells in mucosa....&lt;/p&gt;
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&lt;div&gt;==Photomicrographs of gallbladder samples stained with hematoxylin and eosin in each group==&lt;br /&gt;
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Photomicrographs magnification are 400x. (a) Shows normal gallbladder histology. (b) CBDL-1 group showing edema, congestion and inflammatory cells in mucosa. (c) CBDL-2 group resembles that of CBDL-2 group. (d) CBDL-3 group shows pronounced edema and significant inflammatory cells in lamina propria..  &lt;br /&gt;
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===Reference===&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;24349344&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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Copyright: © 2013 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.&lt;br /&gt;
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{{Template:Student Image}}&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157730</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157730"/>
		<updated>2014-10-23T14:34:19Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Liver, Gallbladder and Bile Duct */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
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The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 5'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
'''Week 16'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
{|&lt;br /&gt;
|-bgcolor=&amp;quot;FF EF D5&amp;quot;&lt;br /&gt;
|&lt;br /&gt;
===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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{|&lt;br /&gt;
|-bgcolor=&amp;quot;E0 FF FF&amp;quot;&lt;br /&gt;
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===Current Research===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
&lt;br /&gt;
Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
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As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
[[File:Histology of human embryonic liver at 11 weeks.png|300px|thumb|right|Histology of human embryonic liver at 11 weeks]]&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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[[File:3–11_SS_caudal_foregut_endoderm.png|200px|thumb|right|3–11 SS caudal foregut endoderm]] &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22815796&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Malrotation.jpg|thumb|right|200px| Reverse rotation: cecum ended up on left side labelled as black asterisk while ascending colon and terminal ileum shown as white asterisk is running to the right side.]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
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'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
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'''Deep deformities:'''&lt;br /&gt;
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•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
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'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
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•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
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'''Hirschsprung disease'''&lt;br /&gt;
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Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
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'''List of research/articles:'''&lt;br /&gt;
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1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157721</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157721"/>
		<updated>2014-10-23T14:31:09Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Liver, Gallbladder and Bile Duct */&lt;/p&gt;
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&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
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=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
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The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
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==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
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! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 5'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
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'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
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|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
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'''Week 19:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
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|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
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|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
{|&lt;br /&gt;
|-bgcolor=&amp;quot;FF EF D5&amp;quot;&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Current Research===&lt;br /&gt;
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http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
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Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
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As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
[[File:Histology of human embryonic liver at 11 weeks.png|300px|thumb|right]]&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
[[File:3–11_SS_caudal_foregut_endoderm.png|200px|thumb|right|3–11 SS caudal foregut endoderm]] &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22815796&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
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[[File:Malrotation.jpg|thumb|right|200px| Reverse rotation: cecum ended up on left side labelled as black asterisk while ascending colon and terminal ileum shown as white asterisk is running to the right side.]]&lt;br /&gt;
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'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
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- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
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'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
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	&lt;br /&gt;
'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Histology_of_human_embryonic_liver_at_11_weeks.png&amp;diff=157712</id>
		<title>File:Histology of human embryonic liver at 11 weeks.png</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Histology_of_human_embryonic_liver_at_11_weeks.png&amp;diff=157712"/>
		<updated>2014-10-23T14:27:57Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* reference */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Histology of human embryonic liver at 11 weeks==&lt;br /&gt;
&lt;br /&gt;
Paraffin-embedded sections of human embryonic liver at 11 weeks (9 weeks of gestation) stained for Hematoxylin and Eosin (H&amp;amp;E), Alpha-Fetoprotein (AFP), Cytokeratin 18 (CK18), Cytokeratin 19 (CK19) and Cytokeratin 7 (CK7).&lt;br /&gt;
&lt;br /&gt;
===Reference===&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;19841744&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Copyright: © 2009 Tzur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Histology_of_human_embryonic_liver_at_11_weeks.png&amp;diff=157703</id>
		<title>File:Histology of human embryonic liver at 11 weeks.png</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Histology_of_human_embryonic_liver_at_11_weeks.png&amp;diff=157703"/>
		<updated>2014-10-23T14:27:14Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: ==Histology of human embryonic liver at 11 weeks==

Paraffin-embedded sections of human embryonic liver at 11 weeks (9 weeks of gestation) stained for Hematoxylin and Eosin (H&amp;amp;E), Alpha-Fetoprotein (AFP), Cytokeratin 18 (CK18), Cytokeratin 19 (CK19) an...&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Histology of human embryonic liver at 11 weeks==&lt;br /&gt;
&lt;br /&gt;
Paraffin-embedded sections of human embryonic liver at 11 weeks (9 weeks of gestation) stained for Hematoxylin and Eosin (H&amp;amp;E), Alpha-Fetoprotein (AFP), Cytokeratin 18 (CK18), Cytokeratin 19 (CK19) and Cytokeratin 7 (CK7).&lt;br /&gt;
&lt;br /&gt;
===reference===&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;19841744&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Copyright: © 2009 Tzur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157667</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157667"/>
		<updated>2014-10-23T14:09:54Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Pancreas */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
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&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 5'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
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'''Week 19:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
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|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
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|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
{|&lt;br /&gt;
|-bgcolor=&amp;quot;FF EF D5&amp;quot;&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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{|&lt;br /&gt;
|-bgcolor=&amp;quot;E0 FF FF&amp;quot;&lt;br /&gt;
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===Current Research===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
&lt;br /&gt;
Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
&lt;br /&gt;
As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
[[File:3–11_SS_caudal_foregut_endoderm.png|200px|thumb|right|3–11 SS caudal foregut endoderm]] &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22815796&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
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===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157649</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157649"/>
		<updated>2014-10-23T14:07:01Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Pancreas */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 5'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
'''Week 16'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Current Research===&lt;br /&gt;
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http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
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Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
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As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
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Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
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From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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[[File:3–11_SS_caudal_foregut_endoderm.png|200px|thumb|right|3–11 SS caudal foregut endoderm]] &amp;lt;ref name=&amp;quot;PMID22815796&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
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During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
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-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
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-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
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Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
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[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
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| 64% (note: embryo)&lt;br /&gt;
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|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
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[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
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-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
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-regression of mesonephric kidney for more space&lt;br /&gt;
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-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Features of Midgut===&lt;br /&gt;
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'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Hindgut==&lt;br /&gt;
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The hindgut consists of the following organ/structures:&lt;br /&gt;
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*Distal transverse colon&lt;br /&gt;
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*Descending colon&lt;br /&gt;
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*Sigmoid Colon&lt;br /&gt;
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*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157628</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157628"/>
		<updated>2014-10-23T14:02:53Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Pancreas */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 5'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
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|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
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'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
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'''Week 19:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
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|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
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|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
{|&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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{|&lt;br /&gt;
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===Current Research===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
&lt;br /&gt;
Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
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As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
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Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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[[File:3–11_SS_caudal_foregut_endoderm.png|500px|thumb|right|3–11 SS caudal foregut endoderm]]&lt;br /&gt;
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The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
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During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
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-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
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-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
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Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
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[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
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! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
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| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
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[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
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-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
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-regression of mesonephric kidney for more space&lt;br /&gt;
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-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Features of Midgut===&lt;br /&gt;
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'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
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===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
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&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
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'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157622</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=157622"/>
		<updated>2014-10-23T13:58:17Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT (gastrointestinal tract) system is a complicated system that extends from the mouth of the foregut to the anal canal of the hindgut. Its function is to ultimately turn food that is eaten into energy. The GIT system consist of the foregut, midgut and hindgut. Majority of the organs are located in the foregut. This includes the stomach, duodenum, Liver, pancreas and the spleen. Overall in fetal stage of the foregut development there is more rapid growth of already formed organs and important structures such as muscle layers emerge as well as bile production.&amp;lt;ref name=&amp;quot;PMID9551687&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9551687&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The midgut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon.In fetal development after the rotation and fixation of the midgut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; At week 11 midgut retracts back into the abdominal cavity and continues to grow. Hindgut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hindgut instead it gets pushed to the left side by midgut during development.The colon matures and lengthens and the anal canal is formed.The following page will explain the key fetal stage development of each segment of the Gastrointestinal tact (foregut, midgut and hindgut), some current research and models used to explain GIT system fetal development as well as the common fetal stage abnormalities and briefly list common abnormalities occurring in the embryonic stage.&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 5'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Duodenum Lumen of the duodenum becomes progressively small and occludes]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
'''Week 16'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Pancreas Insulin secretion begins by pancreas]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Villi formation in Small Intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 16'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Appearance of Villi throughout the Intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
{|&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Intestine Transplant Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. An overview of the process is shown in the digram on the right. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
[[File:Fetal Colonic Inury Model Diagram.png|right|500px]]&lt;br /&gt;
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Diagram of Fetal Injury Colonic Transplantation Model&amp;lt;ref name=&amp;quot;PMID3858813&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3858813&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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{|&lt;br /&gt;
|-bgcolor=&amp;quot;E0 FF FF&amp;quot;&lt;br /&gt;
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===Current Research===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw).&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID16369776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16369776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
'''Thymosin Beta 4 Immunoreactivity in GIT system during  fetal stage development'''&lt;br /&gt;
[[File:Thymosin B4 detection in foetal developing ileum.jpg|right|270px|A)Fetal stomach with Tβ4-immunoreactive granules shown by arrow. Arrow head show the Tβ4 granular deposits located in the mucous of the gastric surface. B)Stomach of adult with intense reactivity for Tβ4 (arrow).]]&lt;br /&gt;
&lt;br /&gt;
Recent study collected data which suggested expression of Tβ4 (Thymosin Beta 4) peptide in human gastrointestinal tract during development. The study obtained 2 human fetuses, a male at 20 weeks of gestation and female at 21 weeks. Samples from the different segments of the, gut such as liver, pancreas, stomach, ileum and colon was collected.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
All the different intestinal segments including glands showed immunoreactivity for Tβ4 however each segments/sites had different levels of this. Highest reactivity for Tβ4 was seen in adult liver and pancreas while the lowest seen in the fetal developing liver. Interestingly granular reactivity for Tβ4 was seen in the epithelium that covered the ileal villi and even more in the cytoplasm of mucous cells (as can be seen on the right). Peptide reactivity was also observed in the mucous of the intestinal lumen at 21 week of gestation.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The high level of Tβ4 its expression during gut development indicates its relevant role for development of the gut.  &lt;br /&gt;
&lt;br /&gt;
As a whole, the data indicated a differentiation stage-specific regulation and expression pattern of Tβ4    in the gastrointestinal tract of human as well as annexed glands during fetal development.  It was therefore suggested that Tβ4 could play variety of roles in development of organs in the GIT system during organogenesis.&amp;lt;ref name=&amp;quot;PMID20161756 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;20161756 &amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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|}&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
&lt;br /&gt;
&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
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Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
[[File:3–11_SS_caudal_foregut_endoderm.png|thumb|right]]&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
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-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
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-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
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Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position themselves as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
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[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. Connected by dorsal mesentery the herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
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|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
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[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches:'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal:''' Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Villi Formation:''' At week nine in fetal development the small intestine contains mesenchyme and pseudo stratified columnar epithelium. Around week 10 small Lumina develop near the base of the epithelium&amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Ridges are formed by an elongation of individual epithelial cells. By approximately week 11 these ridges form a longitudinal zig-zag pattern after folding in a concertina fashion. The main lumen is not in balance with the small lumina formed at the base and as a result there is an extension of the small lumina to the main luminal surface and exofoliation of the redundant cells. This leads to a division of the zig-zag folds into primary villi. Therefore the villi can be seen by week 11 in the small intestine&amp;lt;ref name=&amp;quot;PMID 507402&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 507402&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The primary villi trun into secondary villi following the development of cyst like structures within the epithelium to extend the lumen. By week 16-20 the villi appear throughout the entire intestinal tract. &amp;lt;ref name=&amp;quot;PMID 7158824&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 7158824&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;  &lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|&lt;br /&gt;
|- &lt;br /&gt;
! Abnormality name !! Affected region!! phase of occurrence !! Definition&lt;br /&gt;
|-&lt;br /&gt;
| Esophageal atresia || Foregut (Esophagus) || occurs in 8th week || 1 in 3000-4500 birth- results from deviation of trachoesophageal septum and there is incomplete separation of the eosphagus from laryngotracheal tube. &lt;br /&gt;
|-&lt;br /&gt;
| Eosphageal stenosis || Foregut (Esophagus) || during week 8 || Due to incomplete recanalisation of Esophagus&lt;br /&gt;
|- &lt;br /&gt;
| Congenital hypertrophic pyloric stenosis ||Foregut (stomach)  || onset at 3rd week  and can present neonatally || 1 in 150 male and 1-750 female- muscular thickening of the pylorus &lt;br /&gt;
|- &lt;br /&gt;
| Anal agenesis || Hindgut || week 7 || Anal canal end blindly or ectopic anus, or anoperineal fistula. Anal canal may open into vagina in female or urethra in male. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. [[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;8590188&amp;lt;pubmed&amp;gt;8590188&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. &amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowel is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &amp;lt;ref name=&amp;quot;PMID23554304&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23554304&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a feature of the below abnormality (Cloacal Extrophy). It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Reverse rotation'''&lt;br /&gt;
&lt;br /&gt;
Congenital abnormality of the Midgut seen in one of 5000 live births. Normally after the midgut has undergone retraction into the abdominal cavity it undergoes a 180 degree counterclockwise rotation at week 10-11. Reverse rotation is when this midgut loop rotates in clockwise direction instead. Doudenum lies anterior to the superior messentric artery ( normally it should lie posteriorly) and transverse colon lies posterior instead of anterior to it ( artery).  &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;24963436&amp;lt;pubmed&amp;gt;24963436&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is crucial that an early diagnosis is done as there are life threatening complications associated with it. &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID23528997&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23528997&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMC3691347&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&amp;lt;ref name=&amp;quot;PMC1683643&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;PMC1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=File:3%E2%80%9311_SS_caudal_foregut_endoderm.png&amp;diff=157610</id>
		<title>File:3–11 SS caudal foregut endoderm.png</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=File:3%E2%80%9311_SS_caudal_foregut_endoderm.png&amp;diff=157610"/>
		<updated>2014-10-23T13:53:38Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: ==3–11 SS caudal foregut endoderm==

DiI labelling of the endoderm of individual 3-11 SS embryos and culturing at approx 9.5 dpc. Position and size of the DiI labelled endoderm from a single embryo is illustrated through its shape. The colour indicat...&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==3–11 SS caudal foregut endoderm==&lt;br /&gt;
&lt;br /&gt;
DiI labelling of the endoderm of individual 3-11 SS embryos and culturing at approx 9.5 dpc. Position and size of the DiI labelled endoderm from a single embryo is illustrated through its shape. The colour indicates which organ bud contributed to the end of culture. Simple compass is provided indicating the embryonic axis. &lt;br /&gt;
&lt;br /&gt;
===Reference===&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22815796&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Copyright: © 2012 Angelo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=155912</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=155912"/>
		<updated>2014-10-22T22:01:49Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Tract) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development.&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Proliferation of mesenchyme]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas)&amp;lt;ref name=&amp;quot;PMID23630303&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23630303&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;  is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue&amp;lt;ref name=&amp;quot;PMID22743232&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22743232&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This tissue is within the parenchyma of the exocrine glandular tissue.&amp;lt;ref name=&amp;quot;PMID15072563&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;15072563&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure. &amp;lt;ref name=&amp;quot;PMID23597482&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23597482&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
&lt;br /&gt;
The hindgut consists of the following organ/structures:&lt;br /&gt;
&lt;br /&gt;
*Distal transverse colon&lt;br /&gt;
&lt;br /&gt;
*Descending colon&lt;br /&gt;
&lt;br /&gt;
*Sigmoid Colon&lt;br /&gt;
&lt;br /&gt;
*Rectum (Cloaca before urogenital partitioning)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Urorectal_septum.png|300px|thumb|left|Cloaca of human embryo from twenty-five to twenty-seven days old.]]&lt;br /&gt;
[[File:Cloacal_partition_completed.png|300px|thumb|right|Tail end of human embryo; from eight and a half to nine weeks old.]]&lt;br /&gt;
&lt;br /&gt;
During embryological development, human gastrointestinal and urinary tract share a common vessel known as the cloaca. By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme, will have formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are referred to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continuous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is supplied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
===Colon Development===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
During fetal stages, the Colon undergoes lengthening and maturation. After the abdominal cavity has enlarged enough to accommodate all of the Gastrointestinal tract, the return of the herniated small intestines forces the distal end of the colon into its final position in the left side of the peritoneal cavity. the proximal end of the colon returns after the Small intestines, with the cecal end swinging to the right and downwards&lt;br /&gt;
&lt;br /&gt;
* Week 8-12 the intramural ganglia develop&amp;lt;ref name=&amp;quot;PMID1232090&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1232090&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;   &lt;br /&gt;
&lt;br /&gt;
* Week 11: Taeniae Coli and Huastral Clefts begin to appear&amp;lt;ref name=&amp;quot;PMID5556677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;5556677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Circular Muscle in Large intestines form in Week 8 and  Longitudinal muscle formed in Week 12-15&amp;lt;ref name=&amp;quot;PMID12982018&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12982018&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* Week 20 intestinal villi formation is completed. incorporates all of the colon as well as the Small intestines&amp;lt;ref name=&amp;quot;PMID1214115&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1214115&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Cloacal Extrophy'''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg|thumb|right|600px|MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Superficial  anorectal deformities;''' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
'''Deep deformities:'''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
'''Mixed deformities'' '&lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=154868</id>
		<title>User:Z3414515</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=154868"/>
		<updated>2014-10-22T01:43:52Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab Attendance */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
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Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
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Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
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Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
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Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
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Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
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Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
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Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
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Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
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Lab 10 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:09, 15 October 2014 (EST)&lt;br /&gt;
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Lab 11 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:43, 22 October 2014 (EST)&lt;br /&gt;
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==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
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[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
&lt;br /&gt;
==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
&lt;br /&gt;
==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
Microarray Analysis&lt;br /&gt;
&lt;br /&gt;
Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
&lt;br /&gt;
Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
&lt;br /&gt;
Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;br /&gt;
&lt;br /&gt;
'''Group 1'''&lt;br /&gt;
&lt;br /&gt;
* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
&lt;br /&gt;
* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
&lt;br /&gt;
* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
	&lt;br /&gt;
* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
	&lt;br /&gt;
* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
	&lt;br /&gt;
* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
	&lt;br /&gt;
* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
	&lt;br /&gt;
* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
&lt;br /&gt;
* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
&lt;br /&gt;
* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
&lt;br /&gt;
'''Group 2'''&lt;br /&gt;
&lt;br /&gt;
* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
&lt;br /&gt;
* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
&lt;br /&gt;
* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
&lt;br /&gt;
* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
&lt;br /&gt;
* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
&lt;br /&gt;
* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
&lt;br /&gt;
* I insist for you to put all the references in one place.&lt;br /&gt;
&lt;br /&gt;
* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
&lt;br /&gt;
'''Group 4'''&lt;br /&gt;
&lt;br /&gt;
* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
&lt;br /&gt;
* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
&lt;br /&gt;
* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
&lt;br /&gt;
* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
&lt;br /&gt;
* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
&lt;br /&gt;
* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
&lt;br /&gt;
* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 5'''&lt;br /&gt;
&lt;br /&gt;
* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
&lt;br /&gt;
* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
&lt;br /&gt;
* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
&lt;br /&gt;
* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
&lt;br /&gt;
* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
&lt;br /&gt;
* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
&lt;br /&gt;
* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
&lt;br /&gt;
* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
&lt;br /&gt;
* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 6'''&lt;br /&gt;
&lt;br /&gt;
* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
&lt;br /&gt;
* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
&lt;br /&gt;
* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
&lt;br /&gt;
* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
&lt;br /&gt;
* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
&lt;br /&gt;
* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
&lt;br /&gt;
* Thymus section only has little information so work more on this.&lt;br /&gt;
&lt;br /&gt;
* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
&lt;br /&gt;
* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
&lt;br /&gt;
* Gonad development section is well presented just add images to it. &lt;br /&gt;
&lt;br /&gt;
* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
&lt;br /&gt;
* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
&lt;br /&gt;
* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
&lt;br /&gt;
* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 7'''&lt;br /&gt;
&lt;br /&gt;
* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
&lt;br /&gt;
* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
&lt;br /&gt;
* Brain development section has a very good table and an image. &lt;br /&gt;
&lt;br /&gt;
* Spinal cord development section needs more information.&lt;br /&gt;
&lt;br /&gt;
* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
&lt;br /&gt;
* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
&lt;br /&gt;
* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
&lt;br /&gt;
* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 8'''&lt;br /&gt;
&lt;br /&gt;
* “Making Gains” is pretty funny but offcourse irrelevant to this project. &lt;br /&gt;
&lt;br /&gt;
* Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
&lt;br /&gt;
* Background embryonic development section is well detailed though it lacks images to aid the information.  Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images. &lt;br /&gt;
&lt;br /&gt;
* Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references.  The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154778</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154778"/>
		<updated>2014-10-22T01:33:05Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
  &lt;br /&gt;
&lt;br /&gt;
                            &amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154772</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154772"/>
		<updated>2014-10-22T01:31:30Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
  &lt;br /&gt;
&lt;br /&gt;
&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI|center|&amp;lt;/html5media&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
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Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
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'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
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Definition: &lt;br /&gt;
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Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
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Possible cause: &lt;br /&gt;
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The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
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'''Omphalocele'''&lt;br /&gt;
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Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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'''Hirschsprung disease'''&lt;br /&gt;
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Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
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'''List of research/articles:'''&lt;br /&gt;
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1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154763</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154763"/>
		<updated>2014-10-22T01:30:01Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
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The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
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==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
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| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
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'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
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'''Week 19:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
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|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
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|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Colonic Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Current Reseach===&lt;br /&gt;
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http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;|center|&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
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Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154739</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154739"/>
		<updated>2014-10-22T01:26:00Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
                                  &amp;lt;html5media&amp;gt;https://www.youtube.com/embed/uPBEgBIvRcI&amp;quot;&amp;lt;/html5media&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot;&amp;gt;https://www.youtube.com/watch?v=uPBEgBIvRcI&amp;lt;/html5media&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154718</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154718"/>
		<updated>2014-10-22T01:21:55Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Retraction_of_Midgut Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
'''Week 19:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Peyers patches formed in small intestine]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Current Reseach===&lt;br /&gt;
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http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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                                  &amp;lt;html5media&amp;gt;https://www.youtube.com/embed/uPBEgBIvRcI&amp;quot;&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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&amp;lt;html5media width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot; src=&amp;quot;//www.youtube.com/embed/uPBEgBIvRcI&amp;quot; frameborder=&amp;quot;0&amp;quot; allowfullscreen&amp;gt;&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
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Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
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From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
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The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
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During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
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-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
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-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
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Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
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[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
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[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
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-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
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-regression of mesonephric kidney for more space&lt;br /&gt;
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-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Features of Midgut===&lt;br /&gt;
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'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
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Blood supply: inferior mesenteric artery&lt;br /&gt;
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===Cloaca partitioning===&lt;br /&gt;
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By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
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The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
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===Anorectal deformities===&lt;br /&gt;
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There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
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- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
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- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
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''Cloacal Extrophy''&lt;br /&gt;
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If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
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'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
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{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
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|}&lt;br /&gt;
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'''DURING FETAL STAGE'''&lt;br /&gt;
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'''Cleft Palate'''&lt;br /&gt;
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Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
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Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
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'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
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Definition: &lt;br /&gt;
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Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
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Possible cause: &lt;br /&gt;
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The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
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'''Omphalocele'''&lt;br /&gt;
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Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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'''Hirschsprung disease'''&lt;br /&gt;
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Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
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'''List of research/articles:'''&lt;br /&gt;
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1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154667</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154667"/>
		<updated>2014-10-22T01:09:05Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
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The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
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==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
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! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
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| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
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'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
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|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
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|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Retraction of Midgut]&lt;br /&gt;
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|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
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|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Colonic Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Current Reseach===&lt;br /&gt;
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http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;html5media&amp;gt;https://www.youtube.com/embed/uPBEgBIvRcI&amp;quot;&amp;lt;/html5media&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
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The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Stomach===&lt;br /&gt;
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Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
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Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
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As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154607</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154607"/>
		<updated>2014-10-22T00:58:08Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
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&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
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=Gastrointestinal System=&lt;br /&gt;
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==GIT system Overview ==&lt;br /&gt;
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The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
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==Timeline ==&lt;br /&gt;
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{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
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          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
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'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
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'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
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'''Week 12:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
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'''Week 13:'''&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
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'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
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'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
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|}&lt;br /&gt;
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==Current Research, Models and Historic Findings==&lt;br /&gt;
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http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
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===Current Models===&lt;br /&gt;
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'''Fetal Colonic Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Current Reseach===&lt;br /&gt;
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http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
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In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
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&amp;lt;iframe width=&amp;quot;420&amp;quot; height=&amp;quot;315&amp;quot; src=&amp;quot;//www.youtube.com/embed/uPBEgBIvRcI&amp;quot; frameborder=&amp;quot;0&amp;quot; allowfullscreen&amp;gt;&amp;lt;/iframe&amp;gt;&lt;br /&gt;
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The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
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Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
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Blood supply: Celiac artery&lt;br /&gt;
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===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
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The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
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The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
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During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
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The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
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The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
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During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
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-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
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-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
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Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
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[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
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[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
===Cloaca partitioning===&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the mesenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
===Anorectal deformities===&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154142</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154142"/>
		<updated>2014-10-21T21:42:27Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Liver, Gallbladder and Bile Duct */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells.&lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154139</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=154139"/>
		<updated>2014-10-21T21:37:26Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
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&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| Embryonic Period|| '''Week 4:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct ]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver obtains a bright reddish appearance due to hematopoiesis]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach 90 degrees clockwise rotation of the stomach]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus Occluded lumen and vacuoles appear in the oesophagus]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus The outer and inner muscle layers of the oesophagus development]&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach  Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29 Embryonic Rotations]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning Cecum diverticulum appears] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|Fetal Period|| '''Week 9-10:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Liver is 10% of the total fetus weight] &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin] &lt;br /&gt;
&lt;br /&gt;
'''Week 12:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile formation via hepatic cells begin]&lt;br /&gt;
&lt;br /&gt;
'''Week 13:'''&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium)]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9:'''&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the small intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' &lt;br /&gt;
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*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Midgut Herniation]&lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut Interstitial cells of Cajal present in the large intestine]&lt;br /&gt;
&lt;br /&gt;
'''Week 11:''' &lt;br /&gt;
 &lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation Retraction of Midgut]&lt;br /&gt;
&lt;br /&gt;
|| '''Week 9-10:''' &lt;br /&gt;
&lt;br /&gt;
*[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm]&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
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===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
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Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour.&lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153611</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153611"/>
		<updated>2014-10-21T01:32:21Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153608</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153608"/>
		<updated>2014-10-21T01:21:41Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Oesophagus22750256 */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153605</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153605"/>
		<updated>2014-10-21T01:18:31Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Stomach */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
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Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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===Historic Findings===&lt;br /&gt;
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==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
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The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
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===Liver, Gallbladder and Bile Duct&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
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Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
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===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
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===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
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During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
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==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
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-Ileum&lt;br /&gt;
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-Appendix&lt;br /&gt;
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-Ascending colon&lt;br /&gt;
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-Hepatic flexure of colon&lt;br /&gt;
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-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
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-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
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Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
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===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
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===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
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'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
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===Features of Midgut===&lt;br /&gt;
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'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
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Blood supply: inferior mesenteric artery&lt;br /&gt;
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'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153602</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153602"/>
		<updated>2014-10-21T01:09:11Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Liver, Gallbladder and Bile Duct */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153587</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153587"/>
		<updated>2014-10-21T00:25:31Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Duodenum */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
===Pancreas===&lt;br /&gt;
&lt;br /&gt;
The ventral pancreatic bud and the dorsal pancreatic bud are two caudal outgrowths from the forming liver. The endoderm develops into branched tubules which are attached to the secretory acini (exocrine pancreas) within each bud. Islet of Langerhans (endocrine pancreas) is formed by stem cells at the duct branch points. This then develops into discrete islands of vascular endocrine tissue. This tissue is within the parenchyma of the exocrine glandular tissue. &lt;br /&gt;
&lt;br /&gt;
The ventral and dorsal buds fuse together via the primary rotation of the gut tube which gives a single organ in the adult. The head of the pancreas consist of an uncinated process which is derived from the ventral pancreatic bud. The rest of the head, body and tail of the pancreas are derived from the dorsal pancreatic bud. The distal duct systems of both ventral and dorsal buds join together to form the main pancreatic duct, which drains into the common bile duct. At this site, duodenal papilla is present. Failure for the fusion of buds can lead to annular pancreas.&lt;br /&gt;
&lt;br /&gt;
During the 5th month of development, insulin secretion begins. Along with duodenum, the pancreas is also pressed against the posterior abdominal wall hence becomes a retroperitoneal structure.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153584</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153584"/>
		<updated>2014-10-21T00:23:40Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Duodenum */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior abdominal wall as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153563</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=153563"/>
		<updated>2014-10-20T23:54:55Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Duodenum&lt;br /&gt;
* Pancreas&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
===Duodenum===&lt;br /&gt;
&lt;br /&gt;
The proximal duodenum if formed by the caudal part of the foregut. Proximal duodenum is supplied by the anterior and posterior branches of the superior pancreaticoduodenal artery. This is a branch of the celiac artery. The duodenum and the pancreas are pushed up against the posterior wall of body as the rotation of the stomach takes place. The mesothelium which is covering the duodenum contracts and eventually fuses with the mesothelium covering the posterior abdomen wall. Due to this the duodenum becomes located behind the peritoneum which is known as retroperitoneal. However since the duodenum has not yet began its development in a retroperitoneal position, it is said to be secondary retroperitoneal organ.  &lt;br /&gt;
&lt;br /&gt;
During 5th and 6th week of development, the lumen of the duodenum becomes progressively small and occludes. The lumen recanalizes by the end of week 8. If recanalization fails, this results in duodenal stenosis or atresia. Most of the ventral mesentery of the duodenum has disappeared by this time.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! BEFORE FETAL STAGE&lt;br /&gt;
|- &lt;br /&gt;
|{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=152885</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=152885"/>
		<updated>2014-10-20T02:28:21Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Oesophagus */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Pancreas&lt;br /&gt;
* Duodenum&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;=== &lt;br /&gt;
&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Fetal Midgut.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
'''BEFORE FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
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'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
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Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
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&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
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'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=152879</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=152879"/>
		<updated>2014-10-20T02:20:36Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
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&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160613005605&lt;br /&gt;
(I have found this can someone confirm its ok to use so then ill start summarising it thanks )&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
[[File:Https://www.youtube.com/watch?v=uPBEgBIvRcI|thumbnail|center|Foregut Development]]&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Pancreas&lt;br /&gt;
* Duodenum&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Fetal Midgut.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
'''BEFORE FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=152678</id>
		<title>2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=2014_Group_Project_3&amp;diff=152678"/>
		<updated>2014-10-19T22:32:19Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Foregut */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014header}}&lt;br /&gt;
&lt;br /&gt;
=Gastrointestinal System=&lt;br /&gt;
&lt;br /&gt;
==GIT system Overview ==&lt;br /&gt;
&lt;br /&gt;
The GIT system is a complicated system that extends from the Esophagus of the mouth to the anal canal of the hind-gut. Its function is to ultimately turn food that is eaten into energy. GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut. Majority of the organs are located in the fore-gut. This includes the stomach, duodenum, Liver, pancreas and the spleen. The mid-gut begins below the hepato-pancreatic ampulla and consist of the lower Duodenum, Jejunum, Ileum, Cecum, Appendix and the Ascending colon  as well as the first two third of the transverse colon. In fetal development after the rotation and fixation of the mid-gut is complete, it starts to herniate at beginning of week 6 and continues to do so till week 10. Hind-gut begins from the left third of the transverse colon and ends to the cloaca (rectum). It consists of the left third of transverse colon, descending colon, sigmoid colon, rectum and anal canal. There is no rotation occurring in the hind-gut instead it gets pushed to the left side by mid-gut during development. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Timeline ==&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
                                &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
          !!!!!      GASTROINTESTINAL TRACT DEVELOPMENT              !!!!&lt;br /&gt;
|-&lt;br /&gt;
! Weeks !! FOREGUT  !! MIDGUT !! HINDGUT !!&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 4-8|| '''Week 4:'''&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 6:'''&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Week 7:'''&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
'''Week 8:'''&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
|| '''Week 6:''' &lt;br /&gt;
*Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]  &lt;br /&gt;
||'''Week6:'''&lt;br /&gt;
&lt;br /&gt;
* Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 9-10 || *Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]] || '''week 9''':&lt;br /&gt;
*Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
'''week 10:''' &lt;br /&gt;
&lt;br /&gt;
*Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
*Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
|| *A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| WEEK 11 || || *Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 12 || *Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]  ||&lt;br /&gt;
|-&lt;br /&gt;
|WEEK 13 || *Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
 || &lt;br /&gt;
|-&lt;br /&gt;
|WEEK  || &lt;br /&gt;
&lt;br /&gt;
|}&lt;br /&gt;
--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:51, 17 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Foregut'''&lt;br /&gt;
&lt;br /&gt;
Week 4:&lt;br /&gt;
* Ventral outgrowth (hepatic diverticulum) of liver, gallbladder and bile duct [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 6:&lt;br /&gt;
* Liver obtains a bright reddish appearance due to hematopoiesis [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 7:&lt;br /&gt;
* 90 degrees clockwise rotation of the stomach [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]]&lt;br /&gt;
&lt;br /&gt;
Week 8:&lt;br /&gt;
* Occluded lumen and vacuoles appear in the oesophagus [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* The outer and inner muscle layers of the oesophagus development [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Oesophagus]]&lt;br /&gt;
* Due to the stomach rotation, the duodenum is pulled into a &amp;quot;C&amp;quot; shaped position [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Stomach]] &lt;br /&gt;
&lt;br /&gt;
Week 9:&lt;br /&gt;
* Liver is 10% of the total fetus weight [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week12:&lt;br /&gt;
* Bile formation via hepatic cells begin [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
Week 13:&lt;br /&gt;
* Bile entering via bile duct into the duodenum gives the intestinal contents a dark green colour (meconium) [[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Liver.2C_Gallbladder_and_Bile_Duct]]&lt;br /&gt;
&lt;br /&gt;
'''Midgut'''&lt;br /&gt;
&lt;br /&gt;
Week 6: &lt;br /&gt;
-Embryonic Rotations[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Rotations_.28Embryonic.29]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 9: &lt;br /&gt;
-Interstitial cells of Cajal present in the small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 10:&lt;br /&gt;
-Midgut Herniation[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
-Interstitial cells of Cajal present in the large intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
week 11:&lt;br /&gt;
-Retraction of Midgut[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Midgut_Herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
week 19:&lt;br /&gt;
-Peyers patches formed in small intestine[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Features_of_Midgut]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hindgut'''&lt;br /&gt;
&lt;br /&gt;
Week6-&lt;br /&gt;
&lt;br /&gt;
•	Cecum diverticulum appears[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca_partitioning]] &lt;br /&gt;
&lt;br /&gt;
Week9- &lt;br /&gt;
&lt;br /&gt;
•	A shallow pit known as the anal pit it is formed due to the proliferation of mesenchyme located around the anal membrane giving rise to the surrounding ectoderm[[https://embryology.med.unsw.edu.au/embryology/index.php/2014_Group_Project_3#Cloaca partitioning]]&lt;br /&gt;
&lt;br /&gt;
==Current Research, Models and Historic Findings==&lt;br /&gt;
&lt;br /&gt;
===Current Models===&lt;br /&gt;
&lt;br /&gt;
'''Fetal Colonic Injury Models'''&lt;br /&gt;
&lt;br /&gt;
Using colonic injury models from both fetal humans and mouse it was found that the proliferative immature progenitor cells within the intestines could be expanded in vitro as Fetal Enterospheres (FEnS). Following transplantation after a in a colonic injury model, it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers. This study revealed the existence of transitory populations of progenitor cells during the intestinal growth phase of both human and murine tissues&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
A group of cells with similar characteristics can be obtained from pluripotent stem cells. In comparison to progenitors in the adult state epithelium this population is characterised by distinct proliferative and differentiation potential in reduced in vitro growth factor requirements. Fetal enteric progenitors were found to transition into an adult state after induction in vitro via stimulation with high levels of Wnt. It was found that the same transition could be made using the injury models via in vivo transplantation. These cells give an insight into tissue maturation and provide an attractive source of transplantable progenitors for regenerative therapies&amp;lt;ref name=&amp;quot;PMID24139758&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24139758&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Current Reseach===&lt;br /&gt;
&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed/16369776&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Recent Findings on Omphalocele: &lt;br /&gt;
&lt;br /&gt;
In a recent research experiment, the Hh hedge-hog signalling pathway was believed to be a possible causative factor of omphalocele formation. The TM -inducible gene recombination system was used to show association of Hh signalling with omphalocele. Omphalocele was prominently observed in embryos from dams treated with the higher dose of TM (2 mg/40 g bw) but not with the lower dose (1 mg/40 g bw). The study observed ectopic Hh signal activity in the ventral wall region through del5-LacZ staining and a gain of function mutants of Hh signalling expressed defects in the body wall, therefore results suggested ectopically induced Hh signalling was a potential causative agent in a dose dependant formation of omphacele&amp;lt;ref name=&amp;quot;PMID3024424&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3024424&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Historic Findings===&lt;br /&gt;
&lt;br /&gt;
==Foregut==&lt;br /&gt;
&lt;br /&gt;
The foregut consists of the following organs &amp;lt;ref name=&amp;quot;PMID19575677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;19575677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; :&lt;br /&gt;
* Oesophagus&lt;br /&gt;
* Stomach&lt;br /&gt;
* Liver&lt;br /&gt;
* Gallbladder and Bile Duct&lt;br /&gt;
* Pancreas&lt;br /&gt;
* Duodenum&lt;br /&gt;
&lt;br /&gt;
Nerve supply: ''Refer to specific structures of foregut''&lt;br /&gt;
&lt;br /&gt;
Blood supply: Celiac artery&lt;br /&gt;
&lt;br /&gt;
===Oesophagus=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID22750256&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
The primordium of the oesophagus is a portion between the respiratory diverticulum and stomach dilation. The oesophagus is a short tube initially but elongates significantly over time as the fetus grows. Oesophagus has an endoderm derived epithelial lining which proliferates. The epithelial lining also undergoes a series of transformations. Occluded lumen appears by week eight as well as vacuoles. With time the lumen is recanalized and the vacuoles combine. The epithelium of the oesophagus becomes stratified squamous during the fourth month. The development of muscle layers consisting of outer and inner layers, are recognised by eight weeks. The oesophagus contains smooth (splanchnic mesoderm derivative) and skeletal muscle fibres.&lt;br /&gt;
&lt;br /&gt;
===Stomach===&lt;br /&gt;
&lt;br /&gt;
Dorsal and ventral mesenteries anchor the developing stomach to the body walls. In the 7th week, the stomach undergoes a 90 degrees clockwise rotation about a longitudinal axis. The rotation is such that the right side moves dorsally and left side moves ventrally. The vagus nerve follows this stomach rotation such that the anterior surface becomes left vagus nerve and the right vagus nerve becomes the posterior surface.  Since the left vagus nerve is located on the anterior surface and right vagus nerve on the posterior surface, they are renamed as anterior vagal trunk and posterior vagal trunk respectively. The growth of the dorsal wall of the stomach is faster than the ventral wall. &amp;lt;ref name=&amp;quot;PMID9664826&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9664826&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; The greater and lesser curvatures of the stomach are established via the different growth on the left and right sides. Pylorus is tipped superiorly by cranio-caudal rotation. Pyloric sphincter is formed by the proliferation of the mesoderm derived smooth muscle. This smooth muscle lies in the caudal end of the stomach. The stomach is pulled up by the rotation of the stomach and duodenum about a ventrodorsal (A-P) axis. In the 8th week, due to these rotations, the duodenum is pulled into a C-shaped position. Hence the postnatal position for the stomach and duodenum is achieved.&lt;br /&gt;
&lt;br /&gt;
The greater and lesser omenta are formed by the dorsal and ventral mesenteries of the stomach respectively. Also the ventral mesentery is attached to the developing liver. Distinct spaces of the peritoneal cavity is produced by the rotations of the forgut structures and the development of the omenta. The space posterior to the stomach is called the lesser sac or omental bursa.  The space anterior to the stomach is called the greater sac. The greater sac is anteriorly inferior to the stomach. A small opening is located near the liver’s hilum which is called the epiploic foramen. The greater and lesser sacs communicate through the epiploic foramen. From 4 layers of peritoneum, a thick sheet is forms via the anterior and posterior folds of the greater omentum fusing.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID16052677&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;16052677&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Liver, Gallbladder and Bile Duct=== &lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23799566&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;PMID23720330&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Early in the fourth week of the foregut development, the liver, biliary duct system and gallbladder are seen as ventral outgrowth (hepatic diverticulum). This ventral outgrowth is from the caudal/distal part of the foregut. Hepatic diverticulum is formed via the interaction between bipotential cells and FGF’s which is secreted by the developing heart. There is a mass of splanchnic mesoderm between the midgut and the developing heart. This mass is called septum transversum which is an extension of diverticulum. The ventral mesentry for this region is then formed by the septum transversum. &lt;br /&gt;
&lt;br /&gt;
As the hepatic diverticulum grows in between the layers of ventral mesogastrium, it divides into two parts. Primordium of the liver is the larger cranial part of the hepatic diverticulum. The kupffer cells, fibrous and hematopoietic tissues of the liver are all derived by mesenchyme in the septum transversum.&lt;br /&gt;
&lt;br /&gt;
From the 5th to 10th weeks, the liver grows rapidly and fills the upper abdominal cavity largely. The development and segmentation of the liver is determined by the amount of oxygenated blood flowing from the umbilical vein and into the liver itself. At first, both right and left lobe are of the same size but eventually the right lobe becomes larger. During the 6th week, hematopoiesis begins which gives liver a bright reddish appearance. The liver will account for 10% of the total fetus weight by the ninth week. The bile formation begins during the 12th week. Bile is formed by hepatic cells. &lt;br /&gt;
&lt;br /&gt;
The gall bladder is formed by the small caudal part of the hepatic diverticulum. The cystic duct is formed by the stalk of the diverticulum. The connection between the hepatic and cystic ducts via stalk to the duodenum becomes the bile duct. Initially the bile duct is to the ventral aspect of the duodenum but as the duodenum grows and rotates, the bile duct entrance is carried to the dorsal aspect of the duodenum. After the 13th week, the bile entering the duodenum via bile duct gives the meconium (intestinal contents) a dark green colour. &lt;br /&gt;
&lt;br /&gt;
Ventral mesentery is a thin double layered membrane which gives rise to:&lt;br /&gt;
* The lesser omentum passing from the liver to the lesser curvature of the stomach (hepatogastric ligament) and from liver to duodenum (hepatoduodenal ligament) &lt;br /&gt;
* Extending from the liver to the ventral abdominal wall is the falciform ligament. &lt;br /&gt;
&lt;br /&gt;
From the umbilical cord to the liver, the umbilical vein passes on the border of falciform ligament. Also the visceral peritoneum of the liver is derived from ventral mesentery which is derived from mesogastrum. The whole liver is covered with peritoneum except the bare area which is in direct contact with the diaphragm.&lt;br /&gt;
&lt;br /&gt;
==Midgut==&lt;br /&gt;
Structures of Midgut:&lt;br /&gt;
&lt;br /&gt;
-Ileum&lt;br /&gt;
&lt;br /&gt;
-Appendix&lt;br /&gt;
&lt;br /&gt;
-Ascending colon&lt;br /&gt;
&lt;br /&gt;
-Hepatic flexure of colon&lt;br /&gt;
&lt;br /&gt;
-Cecum&lt;br /&gt;
&lt;br /&gt;
-Jejunum&lt;br /&gt;
&lt;br /&gt;
-Duodenum (distal half of 2nd part, 3rd and 4th parts)&lt;br /&gt;
&lt;br /&gt;
-Transverse colon (proximal two-thirds)&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Nerve supply: Superior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood Supply: superior mesenteric artery&amp;lt;ref name=&amp;quot;PMID24891783&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;24891783&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
===Midgut Rotations (Embryonic)===&lt;br /&gt;
Development of the midgut in the embryonic period is characterized by rapid elongation of the gut and its mesentery. The loops of the week 10 intestine position as shown in the hand drawn illustration below is a result of embryonic rotations.&lt;br /&gt;
&lt;br /&gt;
[[File:Human- fetal week 10 sagittal plane D.jpg|thumb|Week 10 Fetus: Note the excessive size of the liver in the abdominal cavity causing midgut herniation]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Midgut Herniation===&lt;br /&gt;
Herniation of the midgut usually begins around week 5 of the embryonic period. The herniation occurs as a result of the intestine (particularly the ileum) growing faster than the abdominal cavity during this embryonic period. As seen in the table below it is thought that all midgut herniation’s of the fetus should occur by weeks 9-10 &amp;lt;ref name=&amp;quot;PMID14745932&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;14745932&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! Week of Gestation&lt;br /&gt;
! Percentage of Foetuses Herniated&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| 8&lt;br /&gt;
| 64% (note: embryo)&lt;br /&gt;
|-&lt;br /&gt;
| 9&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 10&lt;br /&gt;
| 100%&lt;br /&gt;
|-&lt;br /&gt;
| 11&lt;br /&gt;
| 25%&lt;br /&gt;
|-&lt;br /&gt;
| 12&lt;br /&gt;
| 0%&lt;br /&gt;
|}Table 1.1: Percentage of Herniated midguts during weeks 8-12&amp;lt;ref name=&amp;quot;PMID2528908&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2528908&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Week 10:''' The herniation occurs because of the lack of space in the intra-abdominal cavity mainly due to the large liver and kidneys. As a result the rapidly growing intestinal loops of the midgut are herniated at the umbilicus to accommodate for this lack of space. &lt;br /&gt;
&lt;br /&gt;
[[File:Week 10 Fetal Midgut.png|center|500px]]&lt;br /&gt;
Week 10 Herniated Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Retraction of Midgut===&lt;br /&gt;
'''Week 11:''' The intestinal loops that have migrated to the umbilicus usually return to the abdominal cavity between 8 and 12 weeks of gestation&amp;lt;ref name=&amp;quot;PMID9203209&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;9203209&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. This is shown in figure 1.b as now all the intestine is back in the abdominal cavity in comparison to the week 10 fetus whose midgut was still herniated. Although it is not exactly known why the midgut goes back into the abdominal cavity it is thought that the following factors play a major role:&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
-growth and expansion of the abdominal cavity to cover the herniated midgut&lt;br /&gt;
&lt;br /&gt;
-regression of mesonephric kidney for more space&lt;br /&gt;
&lt;br /&gt;
-reduced growth of the liver for more space&amp;lt;ref name=&amp;quot;PMID8345550&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;8345550&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[[File:Week 11 Midgut Herniation.png|center|500px]]&lt;br /&gt;
Week 11 Midgut&amp;lt;ref name=&amp;quot;PMID2908440&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2908440&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Features of Midgut===&lt;br /&gt;
&lt;br /&gt;
'''Peyer's Patches'''&lt;br /&gt;
Peyer's patches are organised lymphoid nodules. By week 30 of gestation the fetal small intestine contains on average 60 peyer's patches&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. During weeks 15-16 there is a rapid spurt in which the development and maturation of lymphoid follicles of T and B cells allows the continual development of the foci of peyers patches at a continual rate within the small intestine&amp;lt;ref name=&amp;quot;PMID2276071&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2276071&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. At week 19 these aggregations mature into recognisable peyer's patches. In week 24 of gestation the patches become macroscopically visible&amp;lt;ref name=&amp;quot;PMID18668776&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;18668776&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Interstitial cells of cajal'''; Interstitial cells of Cajal (ICC) are specialised network-forming cells that play important roles in the control of digestive motility. In the small intestine c-kit immunoreactive (c-kit IR) cells identifiable as interstitial cells of Cajal appear in week 9. ICC cells then appear in between weeks 10-12 in the large intestine&amp;lt;ref name=&amp;quot;PMID 24414177&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 24414177&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. The ICC cells are only present in the proximal duodenum at the end of the embryonic period  in the form of a wide belt of tightly packed cells around the inception of the myenteric plexus ganglia. The ICC cells emerge in the distal duodenum at the beginning of the fetal period in the arrangement of thin rows of pleomorphic cells at the level of the myenteric plexus&amp;lt;ref name=&amp;quot;PMID 21352475&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt; 21352475&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;.&lt;br /&gt;
&lt;br /&gt;
==Hindgut==&lt;br /&gt;
Innervation: inferior mesenteric plexus&lt;br /&gt;
&lt;br /&gt;
Blood supply: inferior mesenteric artery&lt;br /&gt;
&lt;br /&gt;
'''Cloaca partitioning'''&lt;br /&gt;
&lt;br /&gt;
By the end of week seven, the urorectal septum, a coronal ridge of mesenchyme has formed down the angle between the allantois and hindgut and fuses with the cloacal membrane. This forms an anterior urogenital sinus and a posterior anorectal canal. The anterior portion of the membrane that forms the urogenital membrane is larger than its posterior anal membrane. In Week 9, there is proliferation of the the esenchyme around the anal membrane raising the surrounding ectoderm, forming the proctodeum (a shallow pit). There are swelling around this pit that are refered to as anal folds. The rectal membrane at the base of the anal pit, soon ruptures to create the anal canal which connects the GIT from the rectum to the amniotic cavity.&lt;br /&gt;
&lt;br /&gt;
The junction between the anal pit ectoderm and hindgut endoderm Is designated by the anatomic anorectal or pectinate (dentate) line, the former site of the anal membrane. This area is where the epithelium changes from columnar to stratified squamous epithelium. This squamous tissue begins to keratinise and becomes continueous with the perineum. Within the hindgut portion, the anal canal is supplied by the inferior mesenteric artery, whereas the anal pit is spuulied by the internal pudenal branch of the internal iliac artery&lt;br /&gt;
&lt;br /&gt;
'''Anorectal deformities'''&lt;br /&gt;
&lt;br /&gt;
There are 3 major types of anorectal deformities that can be found clinically&lt;br /&gt;
&lt;br /&gt;
-  imperforate anus (abscent): the rectal membrane doesn’t rupture leaving Gastrintestinal tract to be completely or incompletely walled off from the outside. All varieties of this deformity require immediate surgical intervention at birth&lt;br /&gt;
&lt;br /&gt;
- Insufficient anus leads to problems of meconium evacuation and should be treated without delay&lt;br /&gt;
&lt;br /&gt;
- Ectopic sinus: does allow some intestinal transport, but is usually functionally insufficient&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
''Cloacal Extrophy''&lt;br /&gt;
&lt;br /&gt;
If the cloaca ruptures before completely partitioning, it can lead to extrophy. Although extremely rare with only occuring in one in 200 000-400 000 births, it requires immediate surgical attention postnatal &amp;lt;ref name=&amp;quot;PMID12651743&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;12651743&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. It arises from the failure of the caudal fold to close. Cloacal extrophy results in a child being born with with many inner-abdominal structures exposed. A portion of the large intestine lies outside of the body, and on either side of it are the two halves of the bladder. To diagnose this, MRI Imaging is usually performed during development to detect the 'elephant trunk sign' of cloacal extrophy&amp;lt;ref name=&amp;quot;PMID22878705 &amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;22878705&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
 [[File:383 2012 3133 Fig2 HTML.jpg]]&lt;br /&gt;
 MRI of Cloacal extrophy during fetal development showing omphalocele (a), neural tube defect (b) and bladder exstrophy (c)&lt;br /&gt;
&lt;br /&gt;
	&lt;br /&gt;
'''Developmental problems'''&lt;br /&gt;
&lt;br /&gt;
''Superficial deformities;'' &amp;lt;ref name=&amp;quot;PMID23073994&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;23073994&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
•	Anal agenesis or insufficient anus (with or without fistula): &lt;br /&gt;
•	Membranous atresia or covered anus (with or without fistula&lt;br /&gt;
•	Anorectal agenesis with or without fistula&lt;br /&gt;
&lt;br /&gt;
''Deep deformities:''&lt;br /&gt;
&lt;br /&gt;
•	Pure rectal atresia: complete failure of the formation of the inferior part of the rectum and anal canal&lt;br /&gt;
•	Rectal atresia with fistula: always insufficient. The length and degree of anastomosis differentiate the various types of anomaly&lt;br /&gt;
&lt;br /&gt;
''Mixed deformities'' &lt;br /&gt;
include all forms of ectopic anus&lt;br /&gt;
&lt;br /&gt;
•	May involve abnormal anastomoses of the anus to the perineum and reflect both perineal and cloacal abnormalities&lt;br /&gt;
&lt;br /&gt;
==Abnormalities== &lt;br /&gt;
&lt;br /&gt;
'''BEFORE FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
{{click this red link for further information about disease occuring before fetal stage&lt;br /&gt;
| name       = Congenital malformations and deformations of digestive system&lt;br /&gt;
| title      = [[Congenital disorder|Congenital]] malformations and deformations of [[digestive system]] ([[ICD-10 Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities#(Q35–Q45) digestive system|Q35–Q45]], [[List of ICD-9 codes 740–759: congenital anomalies#Digestive system|749–751]])&lt;br /&gt;
| state      = {{{state|autocollapse}}}&lt;br /&gt;
| listclass  = hlist&lt;br /&gt;
| titlestyle = background:Silver&lt;br /&gt;
| groupstyle = background:#fd6;&lt;br /&gt;
}}&amp;lt;noinclude&amp;gt;&lt;br /&gt;
&amp;lt;/noinclude&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''DURING FETAL STAGE'''&lt;br /&gt;
&lt;br /&gt;
'''Cleft Palate'''&lt;br /&gt;
&lt;br /&gt;
Cleft palate is one of the most common congenital birth defects affecting at rates of 75.9 per 100000 births in 2003.&amp;lt;ref name=&amp;quot;PMID3960056&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;3960056&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Females are affected with this abnormality more than male at ratio of 2:1 according to studies.  It occurs between the 6th and 11th week of fetal development. There is strong data which links to maternal smoking being possible cause of cleft palate in the offspring.&amp;lt;ref name=&amp;quot;PMID1769721214000883&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;1769721214000883/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Alcohol consumption, solvents and agricultural chemicals have also been seen as possible causes however there are many genetic errors (such as aberrant gene variants) that can possibly lead into cleft palate abnormality making its etiology mostly unknown.&amp;lt;ref name=&amp;quot;PMID2825065&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;2825065&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Cleft palate can occur with or without cleft lip. It is a defect of the normal development of soft and hard palate (part of the oral cavity).  Cleft of the palate occurs as a result from disruptions that affect cellular migration, proliferation, apoptosis, extracellular matrix deposition and morphogenetic movements.&amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; These events are all important in the formation of lip and palate. Secondary palate form from the pair of palatal shelves (vertically orientated outgrowths of the maxillary process). The shelves go into a horizontal position just above the tongue by elevating and expanding and then fuse at the midline with each other. When there is disruption/deregulation in any of these processes the shelves are unable to fuse and this is called cleft palate. &amp;lt;ref name=&amp;quot;PMID0059463&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;0059463&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;. Mesenchyme derived from cranial neural crest cells and pharyngeal ectoderms normally interact so that the palate growth and fusion occur. Interruption in the interaction of these two tissues therefore also leads to cleft palate. &lt;br /&gt;
[[File:Different forms of cleft palate.png|thumb|right|400px|A) Incomplete cleft palate  B) unilateral complete cleft lip and palate  C) Bilateral complete cleft palate and lip.]]&lt;br /&gt;
&lt;br /&gt;
Cleft of the palate can either be incomplete, unilateral complete or bilateral complete. Complete cleft means the maximum degree of cleft of any of the types. The image on the right shows the different forms of cleft of the palate (with or without cleft of the lip). The end result of this abnormality leads the roof of the mouth directly connected with nasal cavity.&lt;br /&gt;
&lt;br /&gt;
'''NB:  The picture is showing the roof of the mouth with the nose on top, and the lips just below it in pink and oral cavity in red.'''&lt;br /&gt;
 &lt;br /&gt;
 &lt;br /&gt;
&lt;br /&gt;
'''Gastroschisis'''&lt;br /&gt;
&lt;br /&gt;
Definition: &lt;br /&gt;
&lt;br /&gt;
Gastroschisis is a congenital birth defect which can be diagnosed early in fetal development. It is the most common neonatal abdominal wall defect which occurs equally in males and females. Studies suggest white population is more affected by this abnormality in comparison to Hispanics and dark skinned people.&amp;lt;ref name=&amp;quot;PMID11778986&amp;quot;&amp;gt;&amp;lt;pubmed&amp;gt;11778986&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is a defect of the anterior abdominal wall, usually to the right of the umbilical cord and the peritoneal membrane that normally covers the bowel is absent. The defect involves all layers of the abdominal wall and in this abnormality, an infant’s intestine (small and large intestine) protrude out and into the amniotic fluid. Other organs such as the stomach and liver can also bulge out from the hole and no membrane covers these organs in this abnormality.  &lt;br /&gt;
&lt;br /&gt;
Possible cause: &lt;br /&gt;
&lt;br /&gt;
The cause of Gastroschisis is not completely clear however a potential mechanism include tearing at the base of umbilical cord before the umbilical ring closes or the failure of one or more folds in the abdominal wall to fuse completely and in the correct manner. Due to the failure of the closing as stated above, organs protrude out and the eviscerated bowl is exposed to amniotic fluid for a long period of time, causing mucosal and muscular injury. The organs that remain out of the body wall are also exposed and vulnerable to infection in the open air as an infant is born. In more uncommon cases, chromosomal syndromes such as trisomy 18, 13, or 21 or sex chromosome anomalies have been found in association with Gastroschisis. &lt;br /&gt;
In recent findings Gastroschisis has also been seen to be a result from vascular events causing disruption of fetal abdominal wall. For example Maternal vascular under perfusion is a possible underlying cause of intermittent ischemia to the abdominal wall.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Omphalocele'''&lt;br /&gt;
&lt;br /&gt;
Definition/overview  &lt;br /&gt;
[[File:GIT 2.jpg|thumb|right|300px|Large omphalocele caused due to failure of the intestine at 10 weeks of development to return to abdominal cavity.]]&lt;br /&gt;
 &lt;br /&gt;
Omphalocele is a common midline abdominal wall defect of variable size affecting 2-3 infants per 10,000 births worldwide. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;4075420&amp;lt;pubmed&amp;gt;4075420&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; It is similar to Gastroschisis however, it is characterised with the absence of fascia, muscle, and skin and occurs due to a defect in the development of the muscles in the abdominal wall.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;222976993&amp;lt;pubmed&amp;gt;22976993&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; A fetus with omphalocele tends to have herniation of abdominal contents into the base of the umbilical chord. A membranous sac that has amnion and peritoneum covers these contents lying within the umbilical chord. Omphalocele in the later stage of fetal development (approximately week 11) occurs after normal infolding of the embryo therefore having formed an abdominal cavity. When the umbilical ring does not close around the umbilical cord then this small defect occurs containing only the intestine.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;2960962&amp;lt;pubmed&amp;gt;2960962&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Hirschsprung disease'''&lt;br /&gt;
&lt;br /&gt;
Hirschsprung disease is congenital disease that affects 1 in 5000 live births and has a male dominance over female with a ratio of 4:1.&amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
The gastrointestinal tract derives from endoderm extending from mouth to anus. The function of the GIT depends on the enteric nervous system. Neurons and Glia of enteric nervous system are organised into ganglia. This abnormality is characterised when there is a congenital absence of these neurons in the distal colon (part of Hindgut) of the GIT. The absence of neuron can be due to disrupt in normal migration, proliferation, differentiation, survival or apoptosis of neural crest cells which occurs between the 5th and 12th week of gestation. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;3691347&amp;lt;pubmed&amp;gt;3691347&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Certain mutation in genes such as  GFRα1, NRTN, EDNRB,PHOX2b, SOX10, and SHH have been thought to play a part in the pathogenesis however it is not fully understood. &amp;lt;ref name=&amp;quot;PMID&amp;quot;&amp;gt;1683643&amp;lt;pubmed&amp;gt;1683643&amp;lt;/pubmed&amp;gt;&amp;lt;/ref&amp;gt; Due to this disease the normal function of the Hindgut does not proceed this includes movement such as peristalsis.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4075420&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23553304&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;2960962&amp;lt;pubmed/&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Abnormalities that can occur in GIT system during fetal development'''&lt;br /&gt;
&lt;br /&gt;
'''List of research/articles:'''&lt;br /&gt;
&lt;br /&gt;
1.&amp;lt;pubmed&amp;gt;22777173&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;ref&amp;gt;Charles D. Bluestone M.D., Roy Kerry M.D. andWilliam K. Sieber M.D,2009,January,Congenital esophageal stenosis†‡,The Laryngoscope,volume79,issue 6,1095–1104,http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1288/00005537-196906000-00004/pdf}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===References===&lt;br /&gt;
&amp;lt;references/&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=152639</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=152639"/>
		<updated>2014-10-19T22:19:00Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Discussion */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014discussionheader}}&lt;br /&gt;
==Peer Reviews==&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! Reviews&lt;br /&gt;
|- &lt;br /&gt;
| A nice overview is presented for basic information to be presented onto the project page, with a descriptive introduction into the topic of GIT. Perhaps this section could include a brief mention of the aims of the page and perhaps a few images to make it more visually appealing. Timeline section is particularly extensive, however perhaps the layout can be altered- either adding further information to each developmental stage or even using a table format with images to aid the readers understanding of the processes. The subheadings of this section were also a particularly nice way to structure the information. Recent findings needs a bit more work- perhaps a particular focus could be established for this section of even links to a few articles organised by research into particular organs of the GIT. A few images would also increase the visual appeal to this section. The main body of information (foregut, midgut and hind-gut) are well covered and written- there is evidence of extensive research and work put into this section. The hand drawing idea was also particularly a good idea also with a proper description added to the image. Formatting to this section could be a little more unified however as some section use different styles of bullet points and ways to present the information. Deformities section is greatly informative; perhaps a few more should be presented with accompanying images. The overall references section was formatted correctly. &lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
&lt;br /&gt;
----&lt;br /&gt;
I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
&lt;br /&gt;
I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
&lt;br /&gt;
Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
&lt;br /&gt;
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&lt;br /&gt;
Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
 &lt;br /&gt;
Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
&lt;br /&gt;
There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
&lt;br /&gt;
It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
&lt;br /&gt;
A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
&lt;br /&gt;
Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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====Weaknesses====&lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST)&lt;br /&gt;
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We need to find recent research articles on stem cell on this weekend people. By this friday night please try to finish your section of this project so on the weekends we can focus on current models/findings and historical findings. Thanks group :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:00, 15 October 2014 (EST)&lt;br /&gt;
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I didn't like having to get through all the peer reviews to get to discussion. I collapsed it for ease of use --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 11:51, 19 October 2014 (EST)&lt;br /&gt;
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well done z3375627 for collapsing the discussion section. It makes a whole lot easier for us now :) and ALSO thank you z3415242 for doing the timeline table. It looks good but obviously we need to try to add a bit more information on it. Lets get our sections finished first people THEN we can worry about the editing. ALSO do not forgot to contribute a stem cell research paper on the facebook group so we can discuss it. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 16:44, 19 October 2014 (EST)&lt;br /&gt;
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ok so looking through the peer reviews the main things that people were talking about were: make sure that we tabulate our information, add more models and research findings and then there were things more related to the individual assessments. So its good that someone has started to tabulate our timetable but its a bit all over the place at the moment so we probably need to fix it up a bit. and then we really need to get onto the research findings ect.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 19:08, 19 October 2014 (EST)&lt;br /&gt;
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People do not forget to add reference for the image within the image if that makes sense. And we need to finish our part of the project as well as current findings, models and historic finding by tomorrow night or by wednesday lab PLEASEEEEE. This is because we need to spend a day on editing the page overall as a whole with consideration to the peer reviews. ALSO we MUST have a gathering so we can do this editing together either on wednesday after lab OR thursday. THANK YOUUU :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:18, 20 October 2014 (EST)&lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
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&amp;lt;/gallery&amp;gt;&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=152318</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=152318"/>
		<updated>2014-10-19T05:44:14Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Discussion */&lt;/p&gt;
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==Peer Reviews==&lt;br /&gt;
{| class=&amp;quot;wikitable mw-collapsible mw-collapsed&amp;quot;&lt;br /&gt;
! Reviews&lt;br /&gt;
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| A nice overview is presented for basic information to be presented onto the project page, with a descriptive introduction into the topic of GIT. Perhaps this section could include a brief mention of the aims of the page and perhaps a few images to make it more visually appealing. Timeline section is particularly extensive, however perhaps the layout can be altered- either adding further information to each developmental stage or even using a table format with images to aid the readers understanding of the processes. The subheadings of this section were also a particularly nice way to structure the information. Recent findings needs a bit more work- perhaps a particular focus could be established for this section of even links to a few articles organised by research into particular organs of the GIT. A few images would also increase the visual appeal to this section. The main body of information (foregut, midgut and hind-gut) are well covered and written- there is evidence of extensive research and work put into this section. The hand drawing idea was also particularly a good idea also with a proper description added to the image. Formatting to this section could be a little more unified however as some section use different styles of bullet points and ways to present the information. Deformities section is greatly informative; perhaps a few more should be presented with accompanying images. The overall references section was formatted correctly. &lt;br /&gt;
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*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I can not find a ‘historical findings’ section? &lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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====Weaknesses====&lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST)&lt;br /&gt;
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We need to find recent research articles on stem cell on this weekend people. By this friday night please try to finish your section of this project so on the weekends we can focus on current models/findings and historical findings. Thanks group :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:00, 15 October 2014 (EST)&lt;br /&gt;
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I didn't like having to get through all the peer reviews to get to discussion. I collapsed it for ease of use --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 11:51, 19 October 2014 (EST)&lt;br /&gt;
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well done z3375627 for collapsing the discussion section. It makes a whole lot easier for us now :) and ALSO thank you z3415242 for doing the timeline table. It looks good but obviously we need to try to add a bit more information on it. Lets get our sections finished first people THEN we can worry about the editing. ALSO do not forgot to contribute a stem cell research paper on the facebook group so we can discuss it. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 16:44, 19 October 2014 (EST)&lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
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&amp;lt;/gallery&amp;gt;&lt;/div&gt;</summary>
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		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150842</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150842"/>
		<updated>2014-10-15T02:00:27Z</updated>

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==Peer Reviews==&lt;br /&gt;
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*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I can not find a ‘historical findings’ section? &lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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====Weaknesses====&lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST)&lt;br /&gt;
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We need to find recent research articles on stem cell on this weekend people. By this friday night please try to finish your section of this project so on the weekends we can focus on current models/findings and historical findings. Thanks group :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:00, 15 October 2014 (EST)&lt;br /&gt;
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we ned&lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
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		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150830</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150830"/>
		<updated>2014-10-15T01:57:54Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Peer Reviews */&lt;/p&gt;
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==Peer Reviews==&lt;br /&gt;
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*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I can not find a ‘historical findings’ section? &lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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====Weaknesses====&lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST) &lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
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		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150827</id>
		<title>Talk:2014 Group Project 3</title>
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==Peer Reviews==&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I can not find a ‘historical findings’ section? &lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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====Weaknesses====&lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST) &lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
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		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150821</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150821"/>
		<updated>2014-10-15T01:56:00Z</updated>

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==Peer Reviews==&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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====Strengths====&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
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•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
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====Weaknesses====&lt;br /&gt;
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•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
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•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
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•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
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•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
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•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
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•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
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Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
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The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
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This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
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Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
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A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
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There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
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Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
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Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
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I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
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Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
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Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
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Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
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I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
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Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
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I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
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I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
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Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
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Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
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i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
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Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
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Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
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i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
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Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
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Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST) &lt;br /&gt;
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==References==&lt;br /&gt;
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Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
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&amp;lt;/gallery&amp;gt;&lt;br /&gt;
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*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
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I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
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Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150791</id>
		<title>Talk:2014 Group Project 3</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_3&amp;diff=150791"/>
		<updated>2014-10-15T01:47:29Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Peer Reviews */&lt;/p&gt;
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==Peer Reviews==&lt;br /&gt;
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Your introduction to the gastrointestinal system provided a clear overview of what your project is about. I think it would be a good idea to couple this introduction with an image that shows the pathway and divisions of the GIT. The timeline shown is fantastic, it is not only extensive, but it divides the GIT into regions of the foregut, midgut and hindgut as well as the weeks in which key development events take place.  It is in simple, easy to read language, at an element of teaching at the peer level- great work! There is also a reference next to each of these events which reflects the amount of research that took place-well done guys!&lt;br /&gt;
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Your page includes a table with statistics- the percentage of herniated foetuses which adds credibility to your work and gives the reader information on how frequent this abnormality occurs.  Your section for current does not have a lot of information, there is only one reference available for your recent findings. This section of your project needs to be further researched before the submission date.&lt;br /&gt;
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There is more than one hand drawn image is which fantastic! The colours used for it are a bit too bright, however, this shouldn't be too difficult to change, perhaps just adjust the brightness of the picture on paint, or whichever program the picture opens up with on your computer (this is just a very minor critique. The fact that your group project has more than one student hand drawn image shows adherence to the requirement for the project guidelines.  &lt;br /&gt;
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It was great to see only one reference list, as opposed to different reference lists for each section in the project. Your reference list appears to be long, with 24 references however, 16 of these references part of the timeline. More research papers need to be included to make what is already an amazing project, better!  &lt;br /&gt;
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A video of the GIT and the rotations that occur during development would be rotations would be great visual representation of this system due to the nature of its development course. Perhaps you could find one off YouTube or create one.&lt;br /&gt;
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Overall, this is a good project page, well done group and best of wishes!&lt;br /&gt;
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You have covered the key topics in relation to GIT. There is a good progression of topics, beginning with a GIT system overview and moving into more specific foregut, midgut and hindgut explanations. There are no subheadings under Hindgut however in the content box, the subheadings found in the hindgut section could be listed in the content box. In the explanation of the organs there is mentioning of the earlier embryonic weeks of GIT development. This may be important to set up the basis on which the fetal development begins. The page could add an introduction section to mention mention that your page focuses on fetal period of development, just for the knowledge of readers so that they know the page focuses on fetal development. The GIT system overview can be included under the introduction. &lt;br /&gt;
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There was a good use of diagrams, in particular the hand drawn diagrams of midgut herniation and retraction of Midgut. This diagram shows a good understanding of gut formation and is really helpful in explaining it too peer level audiences. Also the diagram of large omphacele in the deformities also shows good understanding. However diagrams would really help wen explaining the Foregut organs like the oesophagus, stomach, liver etc. Reading the text is pretty heavy and pictures and videos would really help in supplementing the text. Images would also be really good for structures like Peyer’s Patches and Interstitial cells of Cajal. &lt;br /&gt;
The timeline shows a good overview knowledge of gut formation and is useful for readers to refer to keep in context when reading the more detailed descriptions further on in the page. The other topics substantially cover all the other topics to a level around teaching level. Further deeper research can be done in particular to do with ‘recent findings’. However group you guys has not included a ‘historic findings’ section which I know you guys will do before the deadline. You guys have discussed recent findings but haven’t discussed current research models. Also there could be more information on the recent findings. The ‘anorectal deformities’ and ‘cloacal extrophy’ descriptions could be added to the main deformities section and it could be emphasized that it is a hindgut deformity. &lt;br /&gt;
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References and citations are done correctly. The link in the recent findings subsection could also should be added to the main reference subsection and removed from the recent findings subsection. The citation number hyperlinks are meant to be put at the end of paragraphs or sentences instead of at the front of them as was done at the start of the ‘Oesophagus’ subsection and in ‘Stomach’. &lt;br /&gt;
In foregut, midgut and hindgut subsections there were a lot of text but there wasn’t enough in text citations within the text. Instead of putting the citation number hyperlinks at the top under the headings they could be included in the text or at the end of the texts. There are little errors like in Hindgut section, under Cloaca partitioning, ‘esenchyme’ was written instead of ‘mesenchyme’. &lt;br /&gt;
Otherwise your page is really good and comprehensive. Too go beyond the normal teach level of information you guys could add more information to historic findings and recent findings. A good recent findings section will give a good contemporary twist to your page, too keep the readers interested. &lt;br /&gt;
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The overview is quite short and lacks citations and images, however this is understandable seeing as it is a draft copy, but please make sure the overview informations are cited and images are included. The information uploaded so far is structured based on the division of the gut into fore-gut, mid-gut and hind-gut, and very easy to follow.&lt;br /&gt;
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An extensive timeline, however the presentation can be improved as this timeline takes a lot of space and consists of a single word or a sentence. Maybe adding more information in the timeline or condensing the timeline in a table format.&lt;br /&gt;
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I don’t understand the recent findings section as only one research paper has been considered. If more will be added then that is fine however when writing about these findings it’s good to incorporate it with other findings rather than simply summarising the results of one article. &lt;br /&gt;
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Foregut, midgut and hindgut are well covered including innervations and structures of those areas. A range of format is used such as table, dot point and full paragraphs, which neatly tie all the information together and allows for a break in between paragraphs. Student redrawn images are a great source and you have referenced from where you have obtained the original image. No images are used for the foregut even though you have mentioned a few organs in detail. Furthermore, it is best to keep your formatting consistent as the dot points in the foregut section differs to those in midgut.&lt;br /&gt;
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Detailed examples of deformities are present in the gastrointestinal system, however more deformities should be looked at and included. Deformities are also mentioned under the subheading of hindgut (Anorectal deformities, cloacal extrophy, and developmental problems), which might be best moved to the deformities block of the project page. This redrawn image is clear and labelled, however there is no reference. &lt;br /&gt;
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Overall the project page is interesting, easy to comprehend and follow, however certain layout issues should be addressed and more information added. &lt;br /&gt;
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This group has done exceptionally well at referencing their information and has a clear references section at the end of the page, (with the exception of the recent findings article which can be fixed up during the editing process). I particularly liked the structure and layout of the page and found it extremely organized and easy to navigate. &lt;br /&gt;
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A point for improvement I’d like to suggest in the introduction is to focus on introducing the process of fetal GIT development rather than on the post-natal structure as that way you can set the scene of what the project is really about. It would be a good idea to summarise the purpose of the page and it’s contents. With the developmental timeline, it would be a great idea to put that into a table and expand a little more on each stage that has been listed, for example include the implications of development of Cajal cells in the small intestine. &lt;br /&gt;
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Additionally, it would be a good idea to include images of the development process to help illustrate rotations and break up the text. I would also suggest to find and briefly elaborate another one or two articles for the recent findings section. There are some links to references under the foregut heading that don’t seem to be referring to any text and should be editing out or moved to the relevant position in the text. Another suggestion is to shift the developmental problems subheading from the hindgut section to under the deformities section as I feel that would be more relevant there. &lt;br /&gt;
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The midgut and hindgut sections were written very well with relevant diagrams to support the information given. The use of original hand-drawn diagrams with colour helps to make the page more visually appealing and interesting to read. Overall the project was coherent and consistent over the different headings. I found it to be well structured and definitely informative. Good job!&lt;br /&gt;
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‘GIT system overview’ section is good but requires more information to introduce the GIT and what the page is going to have information on. Timeline could form part of this section and could also preferable be in the form of a student drawn image or even a table. The overview section also contains no in-text citations. It’s a great idea to split the GIT into the three parts: foregut, midgut and hindgut to aid in understanding. There is not much information on recent findings without any mention of current models as well so perhaps it would be best to address this before final submission.  &lt;br /&gt;
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In the foregut section there is not much mention of blood supply or innervation as was done for midgut and hindgut. Student drawn images are very impressive and referenced correctly with the student template, description, title and copyright information. The features of the midgut section could include some histological drawings or images. The ‘abnormalities’ section does not contain many in-text citations in one of the paragraphs and could include more deformities listed and described with more images, as well as information on how to treat and manage such disorders later in life. There is also no information or images addressing historical findings or current models so this needs to be looked into. &lt;br /&gt;
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The references are correctly done and ordered, and are present at the bottom of the page. Some of the in-text citations aren’t throughout the text like they should be, for example, in the stomach, liver and gallbladder, and oesophagus sections. &lt;br /&gt;
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Overall, good effort so far but more extensive research needs to be conducted for models and findings and more information for Abnormalities, as well as a few minor edits to make the page present more nicely.&lt;br /&gt;
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Good introduction, initial description of fore/mid/hindgut with listing of respective structures gives the reader an anatomical starting point. Fetal development is presented in appropriate depth. There is no acknowledgement of embryonic origin, research or abnormalities. These sections should feature in the introduction to present all parts of the report in the intro. The three separate timelines defeat the purpose of a timeline. These should either be merged into a single large timeline and remain at their present location or moved to introduce the foregut/midget/hindgut sections later on. Recent findings has a single study which is covered in good detail though 2-3 more studies would allow the reader to further understand current GIT Research.&lt;br /&gt;
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In foregut section the dot-points used should match your subheadings. For example duodenum development is covered in the stomach section but is not mentioned in the subheading resulting in its development being hard to find without trawling through the text or “Ctrl-f”. Additionally you seemed to have missed out on pancreas development entirely. Foregut could also use some more images 2-3 would be suffice. Midgut development has great information, strong table, 8/8 drawings(captions required though). Inclusion of histological features gives viewer a microscopic perspective on development. Hindgut cloaca partitioning content is well worded though references are lacking. &lt;br /&gt;
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Anorectal deformities sections should be moved under the Deformities section. The type of dot-point style used should be standardized. Too few abnormalities in the deformities section, though after the hindgut deformities are mover there should be sufficient. There are no references supporting the possible causes of Gastroschisis. The referencing it very good unlike other pages there are no random reference subheadings. In overview format wise quite attractive, information is adequately in-depth in all sections, introduction fails to address whole page,  referencing is great for a draft (exceptions being “introduction” “Liver, Gallbladder and Bile Duct”), some captions aren't present, abnormalities in development section should be moved into deformities/abnormalities section.&lt;br /&gt;
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The introduction is good as it accurately describes what the GIT system is about and the anatomical positions of the features in this system. It also briefly highlights the development stages at embryonic and fetal stages, however ‘embryonic development’ should be mentioned in a little more detail to understand how far in development the fetal stage begins. I also think the introduction should include a sentence or two describing how abnormalities in such organs can lead to these diseases. Basically a bit from each major subheading should be incorporated including current research as an introduction is a summary of the whole page. As for the ‘timeline’, it would’ve been more appropriate to place the timelines under each section, e.g foregut timeline under the ‘foregut’ subheading. This is because viewers would be confused on why there is so much difference in development in one section of the page. A glossary list should be incorporated in a separate subheading to define some of these words such as hematopoiesis so that viewers can fully grasp the information. &lt;br /&gt;
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The information under recent findings is quite interesting and relatable to the content which is GIT fetal development. However, I believe more findings could be incorporated under this subheading. The information under each organ of the three ‘guts’ are quite detailed in fetal development which is good and shouldn’t be too difficult for the viewers to understand. However, I believe the group could include information on the function of these organs as well. The structure of the information under ‘guts’ does not flow in the sense that the midgut includes features and structure whereas the other ‘guts’ do not. The innvervation and bloody supply of the hindgut should be incorporated in a paragraph instead of being listed like that. All the deformities should be places under one subheading to make it easier for viewers to navigate. The abnormalities were also concise and related to the topic. Overall, the content is relating to the topic of the project and addresses key points. It also shows good amount of research, however there seems to be too much information in some parts which could be reduced a bit. The project needs a  coherent flow of the structure.&lt;br /&gt;
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As for images, there needs to be an image under introduction which includes all features of the GIT tract. There are a lot of potential images missing under each subheading except for the ‘midgut’ section. This shows that there has been one person working on this section or one section being focused on in comparison the others. The information used to reference the images is missing in some images such as the ‘Human- fetal week 10 sagittal plane D.jpg’ (although this is uploaded from a different user so this is understandable. However images such a ‘GIT 2.jpg’ need more information including ‘student template’ as well as the reference where the image idea may have come from. Also, if this is a hand-drawn image then please state this as one member did in ‘Week 11 midgut herniation.png’. Overall, I enjoy the use of self-drawn images as it makes it easier to show what the content is saying without going through the stress of looking for an image online that doesn’t relate to the content. However more images definitely need to be added. The use of footnotes is also good and indicates what the images are showing.&lt;br /&gt;
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There are sections where incite referencing are used, however some sections are void of them such as the ‘introduction’ and ‘Liver, Gallbladder and Bile Duct’ (the [6],[7] should be placed next to the text not above the text. The use of a ‘references’ subheading is good the same references have been combined into one number showing that the group knows how to make the references set out. The use of a table in formatting the ‘Percentage of Foetuses Herniated’ is great and shows more that the group has done research.  Overall, this is a good project and if the group makes edits based on the peer-reviews received, this could enhance their project.&lt;br /&gt;
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A good introduction to the page but only outlines the developmental part of the project. Don’t forget to include other sections as well like current findings, abnormalities, etc. Also, no need for the hyphen for foregut, midgut, and hindgut. The development timeline is really good. Its very concise and well-referenced. It could be improved by tabulating the whole thing and maybe try to fuse the three sections together. Also, add an image or drawing of the development of the system. It will definitely help in terms of understanding what is happening at each stage. On recent findings, it’s not as good as the other groups but it’s definitely a start. Most groups write about 2-4 research articles for their current findings sections. As for the development section, each section is very detailed and informative. Maybe add a few images for the foregut section because images are really helpful. As for midgut, great to see images and student drawings. Good job on that. The same can be said for the hindgut section. It’s written well but maybe put the deformities in this section with the “Deformities” section. Deformities (abnormalities) section is good. It is detailed and the image used clearly shows what the disease is like. Maybe writing about 1-2 more abnormalities would make this section better. &lt;br /&gt;
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It terms of citation and referencing, midgut section did the best job. I recommend the other sections to look for a lot more related material. I understand that this topic was divided depending on the region of the GIT, particularly the development section, but make sure to reorganise each section to make the page coherent. As for the images, most of them are well referenced. It wouldn’t hurt to add a few more. It’s great to see a lot of student drawings. Overall, a good project page very detailed in most areas but very little in referencing. In summary, focus on adding more references, making the whole page coherent, and a few more on the abnormalities.&lt;br /&gt;
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The introduction provides a good basic outline of the overview of the GIT. Although, there are no in-text citations in the introduction and all sub-headings are not included into the overview. Be wary of spelling errors such as “GIT (Gastrointestinal Track) consist of the Fore-gut, Mid-gut and Hind-gut” that should read Gastrointestinal Tract consists of the foregut, midgut and hindgut. This section would be better it was expanded upon and images were added. The timeline provides good detail, though would benefit by better formatting and organisation of the information, maybe putting it all into a table, by week will tidy it up. &lt;br /&gt;
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Adding images for the sections will definitely be beneficial. The images hand-drawn are great, although the colours used make it hard to read. If you plan to add anymore drawings, try and use dark colours that allow for easy readability. The images already uploaded are missing copyright, referencing and “student template” information for images such as “fetal week 10 sagittal plane”. I would suggest you look up the tutorial for uploading images on the pages as Mark has extensive information for the proper steps required for uploading images.&lt;br /&gt;
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The deformities section should be re-titled abnormalities as per the assessment criteria and would ensure the group is following similar structure from the other projects. Again, adding an image per disease would be great. Try and do about 1-2 more abnormalities. Great job on putting all the references at the bottom of the page, it makes it very neat and accessible. Overall, a good project just needs a few edits. &lt;br /&gt;
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A good overview of the GIT, very descriptive. This section would need some referencing as most of this info isn’t exactly common knowledge. Some of the sentences seem too short for me e.g. I would reconfigure the third sentence and combine the fourth and fifth sentences into one: ‘The GIT (gastrointestinal tract) consists of three regions: the foregut, midgut and the hindgut. The majority of the organs are located in the foregut, including…..’. You also need to make sure not to use capital letters in the middle of sentences.&lt;br /&gt;
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The timeline is sort of well organized; it’s good that you have it separated for each region so they’re not all muddled up together, but is the info in dot points under the week, or is it just written next to the week? It needs to be kept consistent.  I feel like this section is a bit too spread out as well, a large portion of the left hand side has text, while the entire right side of the screen is empty. You could possible put in a picture showing these 3 regions of the gut to fill in the space? Or maybe format the info into a table, it would make it look more formal and structured. The proper referencing technique should also be used here, not added hyperlinks.&lt;br /&gt;
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The recent findings area is a little sparse, so you should try to find a few more. The title does say findings (plural), so maybe add at least one more. The foregut section is very extensive on the information provided which is good, a lot of research has been made. Visually however, it looks a little bad as all that can be seen is a mass of text. This can be alleviated if the same thing is done as has been with the midgut and hindgut region: the use of bullet points, a small table and the use of images to offset the slabs of text. It makes it more visually appealing. Unlike the midgut portion of the page, if the images are hand drawn, make sure they are clear, legible, and with colours used that will not strain the eye. For the images drawn in that section are messy and the labels hard to read both due to the colour of the pen used and the handwriting. In both the foregut and hindgut, referencing needs to be done. There are slabs of text in both sections where no references are made.&lt;br /&gt;
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The deformities section is good, kept simple with no extensive explanations. Are there only 2 possible deformaties? If so, might be good to write a sentence mentioning that. If not, would be good to have at least 2 more deformities listed. The image drawn in this section is very neat, I like it a lot. The only problem with it is that it’s too small, making it hard to read some of the labels.&lt;br /&gt;
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Overall, I think this page is very well done in terms of content. You have a lot of text, but I think it could do with some more pictures especially to offset some of the large slabs of texts in some areas. Make sure the pictures you have a clear and neat, and make sure you are referencing and doing it correctly.&lt;br /&gt;
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Overall this is a good project; I enjoyed the tailored diagrams and presentation of information in a succinct manner. Information is presented in a logical and coherent manner. The presentation of information into specific components such as foregut, mid gut, hind- gut is great.  &lt;br /&gt;
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The quality of research is exceptional and well presented. Specifically, the subsection of mid gut and the use of visual aids assist immensely in the translation of complex concepts into simple ones. The use of dot-points succeeds in summarizing the information into easily digestible sections. This also improves the clarity of the page. The use of subheadings also assists with the logical analysis of the project. &lt;br /&gt;
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However, the referencing could potentially be more extensive. A further expansion on current research model and findings will prove to be instrumental in generation of a solid understanding of the project hand. I would recommend splitting recent findings into current research models and historic findings. &lt;br /&gt;
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It would have been beneficial to see more information on the foregut section, as this would have provided a pronounced understanding of the topic at hand. It would assist in the comprehension of the data if the timeline were tabulated. Further expansion of the abnormalities would be needed. It would be great if the abnormalities in the hindgut were moved into the abnormal section. The grammar and punctuation is sound and the readability is good. The presentation of information is lucid and shows a sound understanding of the concepts involved. &lt;br /&gt;
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The introduction part of this project provided a good overview of the gastrointestinal tract and its components, also mentioning briefly the changes that occur in the fetal period. However, care must be taken to not capitalise words that are not needed e.g. Foregut, Midgut, Appendix etc. Although the information in the ‘timeline’ section is relevant, its formatting needs a bit of review as there are inconsistencies between the foregut, midgut and hindgut parts. It also seems that the in-text citations have just been arbitrarily placed in chronological order, with each line having a new reference. Also, this information may be better presented in table format to improve readability. Some simple editing may be needed to fix this.&lt;br /&gt;
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The section on ‘Recent findings’ has some good information, however the reference needs to be properly cited and maybe a couple more articles would help give this part some substance. I thought it was effective to have the GIT split into the foregut, midgut and hindgut and then detail the fetal development under those titles. This gave the page a good structure. However, adding some images, both from online and student-drawn to the foregut and hindgut sections would help improve the aesthetics of the page. The hand-drawn images on the midgut section are effective learning tools to a student, but maybe could be drawn a little neater with darker colours as the blue labelling is difficult to read. They should also be captioned. The use of a table to show midgut herniation of fetuses was a good tool as it makes the information easier to read also.&lt;br /&gt;
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Lastly, the section on abnormalities was well-detailed and I liked that the deformities were split into a definition and cause. An image of gastrochisis may be helpful for a reader to visualise the condition though. The in-text citations in this part were properly done and a long list of references being at the end of the page made the project look neat overall. Areas of improvement may be some simple formatting changes and evening out the information across sections, however a solid project so far.&lt;br /&gt;
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In the overview section, the words “GIT” suddenly are used without any explanation as to what abbreviation it is for. Change to “The gastrointestinal (GIT) system is a ….”. There are also some punctuation errors with capital letters being used mid sentence, and words like “till” being used instead of “until”. Adding a picture to the introductory section would make it visually appealing to the readers. &lt;br /&gt;
In the fore-gut section, there are not any pictures and make it really long and dreadful to read by first look. The explanation of the oesophagus  being occluded and recanalized is a bit hard to understand and could use some further explanation / rewording / diagrams to aid. I noticed in the GIT lecture that the rotations that occur in the mid-gut was a hard concept for me to understand, you should definitely add a gif / picture to portray this nicely to the readers. &lt;br /&gt;
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Overall, I think the tone of the page is very dry, and doesn’t include as much information as it should. You should include more detail, and especially some background information as to how and what the structures arise from, as well as explaining the overall function it will hold in the adult. &lt;br /&gt;
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The reference list seems really small, or most the text doesn’t seem relevantly referenced in general. You should check over the reference listings before submission. For the timeline I think it’d be better if you put the fore-gut, mid-gut, and hind-gut were put together, so that we can see the overall development, rather than the individual development of the GIT system.&lt;br /&gt;
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This project overall is very good with a lot relevant information. There is some use of images and hand-drawn images that are excellent. It would be good to see more images, perhaps to complement the timeline section. It is clear the group have worked well together to create a wiki page that flows well and covers all the organs of the gastrointestinal system. All the citations formatted correctly and it is good that all the references appear in one long list at the end of the page. There is still room to add tables, maybe to summarise the timeline. Other groups who presented their timelines in a table achieved an element of wiki-sophistication. There are a few spelling errors in some of the sections (specified below) which need to be corrected so as to not interrupt the flow of information when the reader is reading it. Again, there are only minimal errors or problems with this page, overall it is excellent!&lt;br /&gt;
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The section on the midgut is well presented and thoroughly researched, well done! It is easy to follow and the way it is described makes it easy to imagine visually. However just double check for typos, for example “to that of” is spelt “tot hat of”. Simple error that is easily fixed. These hand drawn images are excellent. The colour coding and minimal use of words is very effective in supporting the written material. &lt;br /&gt;
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The hindgut section is also well written and there is a lot of extensive information. Also double check for spelling, mesenchyme is spelt “esenchyme” in one of the sentences. This area of the project is lacking images detracting from its readability and level of interest. &lt;br /&gt;
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This project page has thus far been completed with really great effort. The introduction is a good detailed description of the gastrointestinal system consisting of all the corresponding organs. Good to see a timeline of all the events, might be useful to format this into a table since it is so extensive.  The ‘recent finding’ section is done well, will however need more info maybe including other studies. Try to look through the GIT development lecture content, there may be some more studies mentioned and these could also refer to others. The ‘foregut’ section is really well detailed and easy to understand, although it would be nice to see some images, drawings or even tables as done in the ‘midgut’ section. The ‘midgut’ section is great, in its formatting, info, visuals and citations, and the drawings in particular are a really good effort.  It would be great if you could try to re-upload the drawings, as it is hard to see some of the labeled structures clearly.  In the section describing the ‘hindgut’ there is a good use of in text citations, just be careful as some parts don’t have them so they may need to be added. Also there are some minor formatting adjustments that may need to be made with some of the dot points. Lastly the ‘deformities’ section is done well, easily understandable and a good structural layout. Might want to add a few more, maybe the ‘Anorectal deformities’ sub heading could be moved into the big ‘deformities’ heading. &lt;br /&gt;
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Finally this page is done well considering there are a number of sections that have to be covered.  Some suggestions that could be helpful include; adding an additional heading for historic findings which is listed in our assessment criteria.  To help find info for this try to search under the “Explore” tab on the left had side of the embryo page, clicking on the sub heading ‘historic embryo’. Also a useful source is the unsw library as it spans a longer period of time and following the unsw search then research the article in the pubmed site.  For the in text citations try to add them after the content rather than before as it’s not clear which parts are from certain references that have been found. Adding some more images especially in the ‘deformities’ section would be good to see. There are only a few minor changes that may need to be addressed. Otherwise you just need to do a little more research to complete the page. So far good work everyone, keep it up.  Good luck :).&lt;br /&gt;
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I believe more of what the page hopes to achieve could be added to the introduction. These outcomes could add to the overall understanding and experience of the page. Also, remember to at least acknowledge the historical findings, recent findings and abnormalities section in the introduction (just state how this page will attempt to cover those areas- just a suggestion though!)&lt;br /&gt;
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The development section has an excellent choice of headings and subheadings. There is correct referencing and strong evident of significant scientific research. I do believe however that this section could be summarised with more information presented in a table. There is also an excellent addition of images and hand-drawn diagrams, which adds to the overall understanding of the section. The hand-drawn images clearly display an element of teaching at the peer level and a strong overall understanding. &lt;br /&gt;
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More recent studies could be added to the ‘recent findings’ section. Only one is currently presented at the moment. It is well explained, correctly referenced and informative though.&lt;br /&gt;
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I believe more abnormalities and deformities could be also added. This section is very informative and correctly referenced. I particularly enjoyed the addition of the hand-drawn diagrams- it was clearly labelled and aided in the overall understanding. Excellent work nevertheless.&lt;br /&gt;
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In this review I intend to highlight the positive features of your project while pointing out some areas that need improvement, in light of the marking criteria provided. &lt;br /&gt;
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I really like the overview on of the topic, it is clear and succinct. However you could elaborate on some of the areas if time permits. I think a developmental time line you have presented is a great way to summaries all the information. I would also like to mention that this summary is very well referenced and gives an over view of the significant event is GIT development. However I think that this information would be best presented in a tabulated form.  Perhaps you could use the following layout: Column1: Week, Column 2: Foregut, Column 3: Mid-gut, Column 4: Hind-gut. It would also be a good idea to include images or diagrams. I particularly like the hand drawn diagrams, they really compliment the text and help visualise the different stages of development. &lt;br /&gt;
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However are two issues with this project, there is little information on current research. I suggest looking up emerging technologies, drugs, treatments for congenital abnormalities in relation to GIT development. You also need to address the topic of Historic Findings, I suggest using textbooks from the library, the UNSW  library database and UNSW embryology page to discover how our understanding of GIT development began and how it has changed. &lt;br /&gt;
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A great start to the project. Make sure you organise and structure the page under the appropriate headings before you submit the project. Good luck!!&lt;br /&gt;
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Introduction is good as it describes and gives an overview about what is happening in the fetal period for foregut, midgut and hindgut. However, it would be better if it mentions that the project is focusing on fetal development, abnormalities, current researches, etc.&lt;br /&gt;
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It is clear to separate the timeline of GIT development for hindgut, midgut and foregut. It is well-researched with much information in this section. However, it would be easier to follow if a table is used and images are included.&lt;br /&gt;
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The hand-drawn images can explain the development well, however the blue colour for labelling is a bit difficult for reading. It would be better if a darker colour is used.&lt;br /&gt;
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It is a good idea to explain the abnormalities in definition and the causes. Some more abnormalities can be included as well as images for better understanding.&lt;br /&gt;
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There is only one reference in recent findings. More researches could be done in this section. Also, a section about historic findings could be included as well.&lt;br /&gt;
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There are a few spelling errors, such as “esenchyme” in the hindgut section and “tot hat of” under midgut section. Some proof-readings are needed.&lt;br /&gt;
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The referencing is overall good, but some more researches have to be done under some sections (abnormalities and recent findings). It is easy to follow as there is a reference list at the bottom of page.&lt;br /&gt;
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It is overall a good project as the development during fetal period is well described. However, more information about recent findings and abnormalities could be included, with the use of images to illustrate the contents.&lt;br /&gt;
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The introduction to the gastrointestinal system development is ok but needs work on as to indicate what will be covered below and any other noteworthy information. However, the introduction does briefly describe the parts of the GIT system as they reader may not be aware of all the structures. Overall, sentence structures need to be improved on as they may lead to confusion. In addition to this certain areas of development have been missed out and need to be included. The strengths and weaknesses are covered below;&lt;br /&gt;
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•	The timeline of GIT development in the embryonic period has been well written and is very concise in conveying what happen in each week.&lt;br /&gt;
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•	Originality is quite important as some images have been drawn up and uploaded. These have been done well and indicate that group project contributors are showing dedication.  &lt;br /&gt;
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•	Most Images have an image name and an image description.&lt;br /&gt;
&lt;br /&gt;
•	Referencing with in-text citations and no random references in between paragraphs. &lt;br /&gt;
&lt;br /&gt;
====Weaknesses====&lt;br /&gt;
&lt;br /&gt;
•	Abnormalities section of the GIT system is quite lacking and so more information on defects as well as image should be provided.&lt;br /&gt;
&lt;br /&gt;
•	Certain organ development areas are also lacking ad need to be included with those already mentioned.&lt;br /&gt;
&lt;br /&gt;
•	More in-text citing should be used and not only centered in some areas.&lt;br /&gt;
&lt;br /&gt;
•	A tabulated form of the timeline would be useful as to allow it to be clearer.&lt;br /&gt;
&lt;br /&gt;
•	Some footnotes are placed in the wrong areas and should be within paragraphs and not be separated.&lt;br /&gt;
&lt;br /&gt;
•	Headings need to be consistent such as using the same font and size.&lt;br /&gt;
&lt;br /&gt;
----&lt;br /&gt;
&lt;br /&gt;
Introduction is good with brief background information on the anatomy of the GIT which is an appropriate starting point for the readers. Fetal development is also described in the introduction, however I suggest including more information on embryonic period and how that leads to fetal development so that the rest of the page can focus more on the fetal stages. I also suggest including parts of each of the major subheadings in the introduction such as the common abnormalities and the recent finding. An image illustrating different organs of GIT can also help with better understanding of the anatomy. There is no referencing in the introduction to support the information provided. &lt;br /&gt;
Regarding the timeline section, the information needs to be tabulated in order to make it easier to compare between organs. Another alternative is to include a small timeline for each of the organs at the beginning of each section. It is very good that each stage of the timeline has been separately referenced; this shows the extensive research that has been conducted. &lt;br /&gt;
&lt;br /&gt;
The recent finding section focuses on only one study in 2006 on hedge-hog signalling pathway. There are a lot of interesting and more recent studies that can be included in this section. As a starting point, you can search for recent models that help in better understanding of GIT development.&lt;br /&gt;
The information under each of the foregut, midgut and hindgut is very detailed and comprehensive; however the structure does not flow through the whole page with mid-gut including different subheadings and diagrams. In my opinion you should break up the foregut and hindgut sections into smaller subheadings and use diagrams like the ones used for midgut. Potential images can also be used in these sections. Additionally, the anorectal deformities under the ‘hindgut’ section can be placed under the deformities section. The “Midgut” section includes very good information and the drawings are helpful in understanding the concept however they need to be captioned. &lt;br /&gt;
&lt;br /&gt;
This project does not include historic findings. I understand that this section is a bit more difficult as it is hard to find information on it. A suggestion I can make is to search for old articles in PubMed (by adjusting the year) which can include key historical events. Review articles that summarise historic findings related to GIT development may also be helpful. The abnormalities are precisely discussed and are relevant to the topic but as mentioned before, I suggest putting all the abnormalities under one subheading to make it easier for the viewers to navigate. &lt;br /&gt;
&lt;br /&gt;
Overall, the main key points are addressed in this project and the content demonstrates extensive research and a good understanding of the concept. In order to facilitate learning and to make it more interesting and understandable for viewers, some of the text can be summarised in diagrams. Dot -points can also be used in some parts instead of paragraphs. The use of hand written drawings was creative and aided in understanding however I would suggest stating that the drawing is handwritten in your page. If the drawing is copied from another image, then the source of that image needs to be included as well.  Also a more complete description of the image will make it easier to understand.&lt;br /&gt;
&lt;br /&gt;
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I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
&lt;br /&gt;
I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
&lt;br /&gt;
Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;br /&gt;
----&lt;br /&gt;
A good introduction to the Gastrointestinal system giving a broad overview of the system.  The timeline is effective in giving a general perception of the gastrointestinal system development. However maybe this could be put into a table format or add pictures to refer to specific or significant development. &lt;br /&gt;
&lt;br /&gt;
There is a great deal of information that is presented in a strong manner however there is a scarce amount of images. Images can help summaries what some of the paragraphs communicate, tables would also be beneficial to make the page more inviting. Otherwise the page appears to overwhelming with just written content and no visual content to reinforce concepts and information. &lt;br /&gt;
I’d like to acknowledge the hand drawn diagram and the efforts taken to do that. Great job. &lt;br /&gt;
There is an inconsistency in the amount of information throughout the page. Some sections lack information more than others, however this can be a room for improvement to insure further research is done in sections like “recent findings”. &lt;br /&gt;
In regards to referencing, I found that it was not as bad, however more referencing in some areas would benefit. &lt;br /&gt;
My biggest criticism is that the page wasn’t coherent and could flow a lot better with communication with each other and figure out a systematic pattern in each section of the GIT that it is broken down into. &lt;br /&gt;
&lt;br /&gt;
Overall, you should look for a balance between information and pictures that complement the information you are trying to get across. Aim for a photo each section. Also focus on the coherence of your page as this will make it seem professional and makes understanding everything easier a the page flows. &lt;br /&gt;
&lt;br /&gt;
----&lt;br /&gt;
Timeline is very clear and easily shows the order of developmental events that occur. Good detailed information about the development of the foregut, midgut and hindgut however more diagrams could be used in the foregut section. Good description of the deformities that can occur and the possible causes however there is no reference for the possible causes of gastroschisis. The recent findings could do with a little more detail or possibly reference another recent finding.&lt;br /&gt;
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&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Discussion==&lt;br /&gt;
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--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 20:38, 13 August 2014 (EST)&lt;br /&gt;
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Alright so lets choose a topic quickly before it gets taken. I would like all of you to post 3 topics that you would like to do (here) in order of importance and the topic that gets chosen the most will win. This is the only way I could think of in order to decide, so sorry. By the way Cardiovascular is taken so we cannot do that any more. My three choices are: Gastrointestinal System, Immune System and Placenta. What are yours?&lt;br /&gt;
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i choose renal, head and neck, GIT --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 22:22, 14 August 2014 (EST)&lt;br /&gt;
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Im thinking GIT. Everyone so far has said GIT so I reckon that might be the best option as i think it will be relatively easy to understand and follow with the whole mid gut, hind gut formation ect.&lt;br /&gt;
--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 12:58, 15 August 2014 (EST)&lt;br /&gt;
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--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 10:16, 16 August 2014 (EST) I have just reformatted your project page heading as the major heading (single =) and capitalised the words). All page sub-heading (two ==).&lt;br /&gt;
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z3415141: I am going to be looking up research of the midgut.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:08, 20 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
I choose to research on abnormalities of the GIT system--[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 13:14, 20 August 2014 (EST)&lt;br /&gt;
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z3375627: I'm going to be doing Hind gut development research --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 13:10, 20 August 2014 (EST)&lt;br /&gt;
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z3414515: I will be researching foregut. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 13:12, 20 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Alright people lets get some work done on this project. I hope everyone could at least write up few paragraphs on their chosen section by Tuesday. Thanks :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 22:18, 30 August 2014 (EST)&lt;br /&gt;
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&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 22:47, 30 August 2014 (EST) I agree, times a wasting. While you have met the required addition of references, tarts all that is currently on your project page.&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)The reference below might help you guys. &lt;br /&gt;
&amp;lt;pubmed&amp;gt;12943221&amp;lt;/pubmed&amp;gt; &lt;br /&gt;
--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Is it only me or is everyone finding it hard to differentiate between embryo and fetal development?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:23, 2 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Yeh I agree there are so many times where they talk about it as one in the same thing. Just have to read really carefully as we don't want to cross over. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:46, 2 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Also with what you have written so far about the oesophagus, it looks good but what are you doing about referencing. Are you just keeping a list that you will put down later or are you getting the information from the resources that you found last week?? --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 14:53, 2 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
I have my references saved on my laptop so when the time comes I can relate the information to specific reference. How are you coming along with your research so far?--[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 00:08, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Just been reading heaps to make sure I get the information right. I'm trying to get a really good understanding of the midgut rotation as I believe it is a critical part in the development of the ftus. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:31, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
I am still waiting for some information from z3375627 and z3415242. Common people get moving!!! Also I meant that in the nicest way possible :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:52, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
I have found a picture to go with the adnormality that i am doing however i will not upload it until everyone is ok with it. I will work to add on the first abnormality i have started and done and continue to research on a second one. If i come across any useful articles for you guys i will post it on this. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 19:02, 9 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Show the group in class your image so we can discuss on it. Also I know everyone must be busy with mid semester exams or assessments so I appreciate the effort you guys are putting in so far. BUT do remember as soon as the mid semester exams are over we need to pick up the pace or pull up our socks for this embryology project. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 09:27, 10 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Common people lets get a move on. I have put up some information on my section though it is on the embryo period, the fetal period is in progress and in detail. The embryo period is only there as a guideline to understand how the stomach actually attains its shape. --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:47, 16 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
i have come across some research articles on omphalocele (abnormality occurs in week 10-12 YAY ) just reading through them as they are pretty long and abit difficult understanding so i'm trying to put some stuff into a paragraph or two will try and upload the stuff for it by this week sometime. cheers --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 21:50, 16 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Alright this is the week to really get a good chunk of it done now that most of our mid sems are over. Not sure if anyone else has any good youtube videos, but because we only get one I'm gonna put this one out there relating to midgut rotation: https://www.youtube.com/watch?v=AscKR_cQExY --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:09, 17 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Also we need to start our list of references so I reckon we just put them down under this heading. Leave the references at the bottom of the page ie. write above the heading references.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 08:18, 17 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
i found a simple sketch drawing of omphalocele just so we have some picture on our page but i don't want to put it on the page yet incase you guys don't like i and since we cant delete it once its up so after your approval i will put it up also i am trying to find good video on organ development since im sure alot are formed by week 10 as i have read in articlese. --[[User:Z3415242|Z3415242]] ([[User talk:Z3415242|talk]]) 00:42, 24 September 2014 (EST)&lt;br /&gt;
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Apologies with my lack of input on this. I’ve added a bit of the Cloacal partitioning and deformities that I’ll expand upon. I’ve also found some great pictures on some of the other GIT deformities. If I’m unable to source permission for them, I’m happy to recreate them --[[User:Z3375627|Z3375627]] ([[User talk:Z3375627|talk]]) 07:55, 24 September 2014 (EST)&lt;br /&gt;
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Definitely put that picture up about Omphalocele. That will work well because I'm talking about midgut herniation so if I talk about it in my stuff then I can just link it so that when you click on it goes down to the bottom of the page to where you talk about it in abnormalities. Not exactly sure how we do that but I'm sure we will work it out.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 13:02, 6 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Hey all just wanted to note that when your referencing from now look at the editing page to see what mark does so that the references are footnotes down the bottom of the page. Obviously you will need to change the reference in the brackets but you get the point. This means that when you do this all the references will come up down the bottom of the page. --[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 23:34, 6 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Not sure if we are supposed to get rid of the references that we used for our group assignment but I just did because they were taking up uneccesary space on our page. Just thought i would say this here just in case we were not meant to.--[[User:Z3415141|Z3415141]] ([[User talk:Z3415141|talk]]) 09:17, 8 October 2014 (EST)&lt;br /&gt;
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Everyone please take off your student signature from the group page as it looks unprofessional. Thanks guys and girls :) --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 10:07, 8 October 2014 (EST) &lt;br /&gt;
&lt;br /&gt;
'''References'''&lt;br /&gt;
&lt;br /&gt;
Won Kyu Kim, Hyun Kim, Dae Ho Ahn, Myoung Hee Kim, Hyoung Woo Park Timetable for intestinal rotation in staged human embryos and fetuses. Birth Defects Res. Part A Clin. Mol. Teratol.: 2003, 67(11);941-5 PMID:14745932. I used this in describing midgut rotation.&lt;br /&gt;
&amp;lt;gallery&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;/gallery&amp;gt;&lt;br /&gt;
&lt;br /&gt;
----&lt;br /&gt;
&lt;br /&gt;
*References are missing from the overview section. Although it serves as an introduction, you can still include references to support what you're saying. Also, maybe the language of this section should be edited to be a bit more formal, like the 2nd sentence in particular&lt;br /&gt;
*GIT = Gastrointestinal tract, not track&lt;br /&gt;
*The hyphens between &amp;quot;foregut&amp;quot; etc are not needed&lt;br /&gt;
*The timeline is a good idea! Everything was simplified. Maybe look to see if you can add some images to this section&lt;br /&gt;
*Week 6 of timeline: I don't think a liver can &amp;quot;obtain&amp;quot; a colour. Look to change the wording&lt;br /&gt;
*Maybe to simplify the timeline section better, tabulate the findings according to time (weeks), rather than dividing it by the midgut, foregut and hind gut section. It makes it hard to follow&lt;br /&gt;
*Need some more work on the recent findings section. Just some tips, when researching on pubmed, there's an option to look at recent articles by customising dates to say 2012-onwards&lt;br /&gt;
*Many potentials for adding images to the &amp;quot;foregut&amp;quot; section. If you find that copyright is too difficult to get around, then you can sketch or trace images from textbooks and upload them&lt;br /&gt;
*Great effort with the drawn images in the &amp;quot;midgut&amp;quot; section! Be wary of colour choice though, as the green highlighter and blue pen can be a bit difficult to see. Otherwise think of adjusting contrast on the images to make the diagram stand out more&lt;br /&gt;
*Maybe think of adding a video from YouTube to show some features of GIT fetal development, like the rotations. If you do that, be sure to include the 11-digit cache code as your reference point&lt;br /&gt;
&lt;br /&gt;
----&lt;br /&gt;
I think that the ‘Deformities’ section should be renamed to ‘Abnormalities’ and I am not sure if that is because it is the correct term but every lecture and similar page on the Embryology wiki uses the term ‘abnormality’ to describe abnormal developments. The page also needs to be more referenced more in some areas (e.g. the possible causes of Gastroschisis section) so as to allow your audience to read more into the text you have presented and give some citations to your information. Some sections are also suffering from a lack of information (e.g. ‘Recent Findings’ – more articles and ‘Abnormalities’ – more abnormalities) and I think some more research would definitely rectify these weak points.&lt;br /&gt;
&lt;br /&gt;
I really liked the use of your own drawings in some of the sections and I think this demonstrates that you understand the concepts. My only criticism is that the images are a bit difficult to interpret because the colours are really hard to see against a white background. It would be good if you included some images from scientific literature as well to give more links to scientific papers.&lt;br /&gt;
&lt;br /&gt;
Overall the page needs some more work and I think some more research and referencing will definitely go a long way in making this page better.  You have the basic scaffold for you page and you only really need to develop some more detail in these areas.&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=150569</id>
		<title>User:Z3414515</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=150569"/>
		<updated>2014-10-15T01:10:11Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab Attendance */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
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Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
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Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
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Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
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Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
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Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
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Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
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Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
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Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
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Lab 10 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:09, 15 October 2014 (EST)&lt;br /&gt;
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==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
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[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
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[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
&lt;br /&gt;
==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
&lt;br /&gt;
==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
Microarray Analysis&lt;br /&gt;
&lt;br /&gt;
Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
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Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
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Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;br /&gt;
&lt;br /&gt;
'''Group 1'''&lt;br /&gt;
&lt;br /&gt;
* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
&lt;br /&gt;
* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
&lt;br /&gt;
* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
	&lt;br /&gt;
* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
	&lt;br /&gt;
* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
	&lt;br /&gt;
* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
	&lt;br /&gt;
* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
	&lt;br /&gt;
* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
&lt;br /&gt;
* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
&lt;br /&gt;
* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
&lt;br /&gt;
'''Group 2'''&lt;br /&gt;
&lt;br /&gt;
* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
&lt;br /&gt;
* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
&lt;br /&gt;
* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
&lt;br /&gt;
* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
&lt;br /&gt;
* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
&lt;br /&gt;
* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
&lt;br /&gt;
* I insist for you to put all the references in one place.&lt;br /&gt;
&lt;br /&gt;
* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
&lt;br /&gt;
'''Group 4'''&lt;br /&gt;
&lt;br /&gt;
* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
&lt;br /&gt;
* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
&lt;br /&gt;
* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
&lt;br /&gt;
* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
&lt;br /&gt;
* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
&lt;br /&gt;
* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
&lt;br /&gt;
* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 5'''&lt;br /&gt;
&lt;br /&gt;
* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
&lt;br /&gt;
* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
&lt;br /&gt;
* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
&lt;br /&gt;
* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
&lt;br /&gt;
* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
&lt;br /&gt;
* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
&lt;br /&gt;
* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
&lt;br /&gt;
* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
&lt;br /&gt;
* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 6'''&lt;br /&gt;
&lt;br /&gt;
* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
&lt;br /&gt;
* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
&lt;br /&gt;
* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
&lt;br /&gt;
* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
&lt;br /&gt;
* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
&lt;br /&gt;
* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
&lt;br /&gt;
* Thymus section only has little information so work more on this.&lt;br /&gt;
&lt;br /&gt;
* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
&lt;br /&gt;
* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
&lt;br /&gt;
* Gonad development section is well presented just add images to it. &lt;br /&gt;
&lt;br /&gt;
* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
&lt;br /&gt;
* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
&lt;br /&gt;
* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
&lt;br /&gt;
* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 7'''&lt;br /&gt;
&lt;br /&gt;
* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
&lt;br /&gt;
* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
&lt;br /&gt;
* Brain development section has a very good table and an image. &lt;br /&gt;
&lt;br /&gt;
* Spinal cord development section needs more information.&lt;br /&gt;
&lt;br /&gt;
* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
&lt;br /&gt;
* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
&lt;br /&gt;
* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
&lt;br /&gt;
* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 8'''&lt;br /&gt;
&lt;br /&gt;
* “Making Gains” is pretty funny but offcourse irrelevant to this project. &lt;br /&gt;
&lt;br /&gt;
* Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
&lt;br /&gt;
* Background embryonic development section is well detailed though it lacks images to aid the information.  Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images. &lt;br /&gt;
&lt;br /&gt;
* Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references.  The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_8&amp;diff=150047</id>
		<title>Talk:2014 Group Project 8</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_8&amp;diff=150047"/>
		<updated>2014-10-14T18:10:42Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* 8 */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{ANAT2341Project2014discussionheader}}&lt;br /&gt;
==Peer Reviews==&lt;br /&gt;
===1===&lt;br /&gt;
Let me start by saying that the “Muscle Gains” section is funny but obviously very irrelevant to the project. Looking at the contents of this page, there seem to be a lot of focus on the development and very little on the other sections. The development section is well-researched and great job on the in-text citations! Some parts look a bit bulky though so maybe try to break some of them down into bulletpoints if possible. A timeline of development is also very helpful in this project.&lt;br /&gt;
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On abnormalities, very concise and detailed. Try to  write about 3-4 abnormalities and find information on how they’re treated or managed presently. As for historic findings, there is a section on the Wikipage that has old books on embryology. It’s under the “Explore” tab and you’ll see “Historic embryo”. Those books have a lot of information regarding that section. Don’t forget to write about current findings as well. Another thing, try to use images since these really help with understanding the content of the page. Overall, a lot of work has to be done before the due date. I do understand why because there are only two people in this group. Goodluck and I wish you the best in finishing this project!&lt;br /&gt;
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===2===&lt;br /&gt;
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The key points of musculoskeletal development appear as headings however there is still much that needs to be clearly discussed beneath each of these points. The main headings are good and specific but some are way too specific and should be under much larger headings, for example, 1.2-1.9 could be subheadings that come under the heading ‘System Development’. ‘Background embryonic development’ is useful to understand but perhaps it is better to not have so much detail, or summarise it in a table. The ‘Abnormalities’ heading is done well, with one disease listed (Duchenne Muscular Dystrophy).  It might be better to have more than one abnormality listed and clearly described as well. I particularly like the use of statistics and genetic references. It seems most of the key points relating to system development have been clearly described, but some tidying up in terms of editing needs to be done. &lt;br /&gt;
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Also, more work needs to be done on historic findings, current research, models and findings.  Once all the research parts are completed, the timeline can be correctly constructed. Also like the idea of putting a timeline and the heading shows that this is intended. More subheadings could be used to make the page look more organised and pleasing to the eye. &lt;br /&gt;
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There are also no graphs or tables as well as pictures. A table could be used to make the timeline or highlight the differences between the second, third trimesters and neonatal periods of fetal muscular development. Maybe the initial heading of the page should be changed to ‘Muscular Fetal Development’ to indicate that muscular development is actually being covered instead of both muscular and skeletal. There also isn’t much information regarding limb fetal development, so maybe it would be good to go through that on a deeper level. &lt;br /&gt;
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It could also help to have images loaded onto the page or to draw flow diagrams to assist in the description of how the muscles develop in the fetal period. For example, upload an image showing the difference between slow twitch and fast twitch muscle fibres or draw a flow chart to show better understanding of the molecular and cellular regulation of fetal myogenesis. &lt;br /&gt;
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References need to be in one larger section at the end under the heading ‘References’, not two and scattered throughout as is seen. The major section of references appears to be referenced correctly and in-cite references are done very well. There are also many references which are good and show that this group has thoroughly researched their topic. &lt;br /&gt;
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Overall, this group has done very well and just needs to add more information for certain headings, as well as organise the page a bit better in neater headings and subheadings. Pictures should be added, as well as graphs, tables and own student-drawn images.&lt;br /&gt;
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===4===&lt;br /&gt;
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Overall the Group project page seems to be set out quite well with its headings and sub headings.  Just needs a bit more info for some of the sub headings particularly from ‘second trimester muscular development’ onwards and a few formatting adjustments. The use of timelines, tables and dot points might help in those sections. The content provided is written well and in a detailed manner, which is still understood.  There is a significant amount of research presented and this is seen through the in text citations and then further identified in the reference list. A good use of referencing is seen supporting the content info provided.  The content uses examples of past and current research to help develop and establish ideas that are presented well. The abnormalities section on ‘Duchenne muscular dystrophy’ is described really well, maybe other abnormalities could also be added later. &lt;br /&gt;
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To improve the page some suggestions include the use of diagrams and images, would help to add a bit more vibrancy to the page. Images and drawings are a great way to help in understanding the content.  They are also a great way to make the content clearer especially if there are a number of processes involved in the development.  Some of the longer paragraphs of content may also be formatted into dot points just to avoid lengthy paragraphs of info. It might also be useful to include some of the headings mentioned on the assessment page (identify current research models and findings, historic findings etc.). &lt;br /&gt;
Finally, the page so far is done well however it will need a little bit more work to be completely finished. Try to just gather as much info as you can to ensure you have enough content and then add images and any other visual aids later. Keep up the good work and good luck :).&lt;br /&gt;
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===5===&lt;br /&gt;
Firstly, I thought the “Making Gains” bit was great- and I can guess who came up with that. I know you’ll take it our prior to submission though haha. The structure of your project is quite good, and the subheadings would make it much easier to read- the only thing is you need to add more content! I think because your system encompasses quite a lot, it would be a better idea for you to put as much information as you can into tables and include diagrams- I saw that musculoskeletal development has quite a few visual resources so it you should use them!&lt;br /&gt;
There are some areas where the content is really sparse, yet others where it is extremely heavy. In these areas, you may benefit from putting your information into bullet points so as to alleviate any confusion that may arise and overall enhance the clarity of your work. The references you have done are quite good, but there appears to be some missing.&lt;br /&gt;
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Overall, I think your project would greatly benefit from the incorporation of images and diagrams. Because you are describing so much, a visual aid will help you immensely and also assist in retaining the attention of the reader throughout the entirety of the piece.  Also, I see that you have deviated from the recommended headings. This may be a good idea to individualise your project- but make sure all topics are covered.  I think it’s a good start considering you only have two team members, and I’m sure you will be able to pull it all together by the time it is due.&lt;br /&gt;
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===6===&lt;br /&gt;
Musculoskeletal&lt;br /&gt;
There is no introduction that has been added - you should really add one because its great to introduce the readers to what will be in the wiki page. I hope the person incharge of the first two sections of your group will / does have some work to add soon. Hardly any information has been added to the majority of the assignment, and to be honest, this wiki project has had the least amount of work done on it. You need pictures, diagrams, graphs and a LOT more information. You guys are doing a “musculoskeletal” topic, and I can’t find anything on “skeletal” on your page yet. Mark has posted that your page will only be focusing on fetal muscle development - why not change the name of the page from musculoskeletal to muscular only? That will prepare the reader in regards to the topic being addressed. &lt;br /&gt;
As for abnormalities, all the other pages have on average 5 abnormalities being introduced, whereas this page only has 1. Although it is really well worded and introduced, I think you should try to find at least another 2 abnormalities to put into your group project. &lt;br /&gt;
Sections for historic findings, current research, models and findings will need to be added. &lt;br /&gt;
Your page seems to focus only on how the actual muscle fibres develop, but perhaps, you could write about skeletal muscle development contributing to limb development or something to widen your topics? &lt;br /&gt;
Overall, your page needs a lot more work! Hope you can get a lot of work done until the project is due, make sure to add pictures!&lt;br /&gt;
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===7===&lt;br /&gt;
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In this project the development section is well-researched however introduction, historical findings, current models and abnormalities still need some work. The development section is very informative with appropriate use of in-text referencing. However, to prevent having bulks of text, you can create diagrams and flow charts or use bullet points. It would also be great if you could provide a timeline under “muscle development general timeline” section. Background embryonic development section is very helpful but we do not need this much information on embryonic period for this project. You can summarise this information in introduction, so that it provides a starting point and fetal development can be further expanded through the project. The rest of the information regarding system development seems to cover the important points; however it still needs work (for e.g. “second trimester muscular development” section is clearly missing some bits).&lt;br /&gt;
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The abnormality section only includes one abnormality (Duchenne Muscular Dystrophy). This abnormality is well described but it needs to be referenced. An image of the clinical manifestation of the disease can clearly help with understanding. There are lots of other abnormalities that you can include in this section (We learnt from the musculoskeletal development lecture that musculoskeletal conditions form 20% of all abnormalities at birth). You can also refer to “limb development lecture” to find information on musculoskeletal abnormalities.&lt;br /&gt;
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Finding information on historic findings might be a little challenging. A suggestion I can make is to search for old articles in PubMed (by adjusting the year). These articles can include key historical events. Review articles that summarise historic findings related to musculoskeletal development may also be helpful. You also need to find information on current research.&lt;br /&gt;
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Finally, you should add an introduction to your project. It seems like you are more focused on muscular development rather than “musculoskeletal” so you can mention that in your introduction. You can also show creativity by drawing your own diagrams, adding images, and tabulating timeline data. You should also fix the references by putting all the references under one subheading in the bottom of the page.&lt;br /&gt;
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===8===&lt;br /&gt;
I think this page needs a lot of work in improving the overall layout. First, I think the page would benefit from a more formal introduction that introduces the content of the page in a way that is helpful to your audience. The age could also be improved by breaking it up into ‘Development’, ‘Historic Findings’, ‘Current Research Models and Findings’ as well as the Abnormalities section already included to make it flow better.&lt;br /&gt;
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The text in under the ‘Molecular and Cellular Reputation of Fetal Myogenesis’ is really good but it is appears as a large slab of information that would be better presented with dot points to break it up and images to make it more interesting. The Abnormalities section is well written but is very brief. This section could be improved by including more abnormalities and the appropriate images. &lt;br /&gt;
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Overall there is a lot of work to be carried out for this page but I understand that this is a smaller group. Perhaps breaking the work up into those smaller headings mentioned will help you split the work evenly. When all the text is uploaded, make sure that there is an effort to include in text citations to support all your information and images to make the page interesting. Try to avoid writing big slabs of information – tabulate or use dot points to break up large portions of text.&lt;br /&gt;
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==4==&lt;br /&gt;
This page needs a lot of work; there are sections with little to no information, while others have just slabs of text, some of which have no references. Of those that have info presented, the topic is well covered with the large amount of content. You should use some dot points for some areas where you have a lot of info. You also need to use some images!! They will help to alleviate the slabs of content you have and add some colour to the page. Make sure you caption and reference them correctly, and add the correct copyright info. &lt;br /&gt;
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Overall, there isn’t much I can say except add content, reference is correctly both in text and at the bottom of the page, and images and use some dot points and/or tables; don’t write everything in large slabs of text. Also, maybe get rid of that 'Muscle Gains' section, unless you actually plan to write something relevant in there haha. Otherwise, Good luck!&lt;br /&gt;
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==5==&lt;br /&gt;
Let me start by saying, for only having two people in the group, well done. The page should have an introduction though, and this is missing. Just by simply summarizing all the information that will be covered in the page and adding it to the introduction, will improve the overall presentation significantly, you may wish to leave this to last, or edit as you go along. &lt;br /&gt;
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The section “Making gains” is amusing, but inappropriate and should be omitted from the final submission. The timeline for the page I believe should be put into a table to save time and add to the presentation of the page, it can be easily done if you follow the steps outlined in the ‘editing basics’ page &lt;br /&gt;
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The background information is comprehensive, however, the page is in desperate need of some images as there are just slabs of text. Images will really help break up the contents of the page and make it visually appealing. &lt;br /&gt;
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The abnormalities section also seems to be coming along quite well. Keep up the good work. &lt;br /&gt;
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==6==&lt;br /&gt;
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This is great work so far from a group consisting of only 2 people. Keep up the good work and continue to work hard in finishing this page. Very admirable.&lt;br /&gt;
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Overall, I would suggest reformatting and adding pictures to enhance the presentation of this page. Consider the use of lists and tables, throughout this wiki.&lt;br /&gt;
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Instead of the rather hilarious (but rather inappropriate) ‘Making gains’ subheading, I believe an introduction should be added. Remember to clearly indicate the outcomes that the page hopes to achieve.&lt;br /&gt;
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I also believe that the development/timeline section of this page is informative, with a very good use of headings and sub-headings. There is excellent evidence of significant scientific research and is correctly referenced and cited. However, this section could be further summarised or improved through the use of a table I believe- just a suggestion however. Adding pictures would also add to the overall understanding of this section.&lt;br /&gt;
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This page has no information for the “recent findings” or “historic findings” section. Remember to include relevant information/pictures and references to these sections.&lt;br /&gt;
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The abnormalities section is also looking very promising. Include more varying abnormalities. The abnormality included, DMD, is well written and informative. It needs to be correctly referenced however. &lt;br /&gt;
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==7==&lt;br /&gt;
In this review I hope to highlight the merits of your project and suggest some areas for improvement in line with the marking criteria. &lt;br /&gt;
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I see that you have conducted a great amount of research on the fetal development of the musculoskeletal system. The content clearly goes beyond the material covered in the lectures. It was interesting to read about the different transcriptions factors involved in induction and regulation of myoblast differentiation. I think it will be good to see a summary of all this information in a timeline format. I suggest simply highlighting the main developments at each stage. &lt;br /&gt;
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You have made a good start on abnormalities. I suggest that you begin by selecting one abnormality include Description; Epidemiology; Cause and Treatment. You can add more later.&lt;br /&gt;
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The page needs a little more structure. Make sure you include appropriate sub-heading and organise the information before you submit the project. Remember we were asked specifically to address the topics of current research and historic findings. &lt;br /&gt;
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Finally it would be good see some images to support the text. Perhaps diagrams on tendon development would help summarise the process. &lt;br /&gt;
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Great work so far!! Hope this feed back helps. &lt;br /&gt;
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==8==&lt;br /&gt;
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Overall, the project has some very detailed sections and some sections where content is scarce. It would be helpful to start off with an introduction of the musculoskeletal system so the reader is aware of its components and what the page intends to cover. The timeline of muscle development has good potential, I understand it is still being planned at this stage and with further research, it could definitely be effective. A table format would be useful to present this information. The following sections on background embryonic development and fetal myogenesis are well-researched and have a lot of content, however I would consider breaking it down into dot points to improve readability. The sections are cited correctly in-text though, which is good to see.&lt;br /&gt;
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There is much more improvement in the tendon and second trimester development sections, as the chunks of text have been reduced to provide a succinct summary, however these need to have citations also. The use of some images here, either hand-drawn or from online would be beneficial, to have a balance between text and pictures and make the page more visually appealing. Other than the abnormalities section which provides a good, concise summary of Duchenne Muscular Dystrophy, the following sections seem to be only references at this stage. As long as these are used to compose some relevant paragraphs/dot points, this is fine considering there is still time to improve the page. &lt;br /&gt;
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Overall, this page has good potential as the groundwork has been completed; it is now more a matter of writing up more information, adding images and possibly a relevant video. The part on ‘making gains’ would need to be removed for the final, but otherwise, it is definitely a decent amount of work so far, especially considering the few group members involved.&lt;br /&gt;
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==9==&lt;br /&gt;
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“Making Gains” is pretty funny but offcourse irrelevant to this project.&lt;br /&gt;
Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
Background embryonic development section is well detailed though it lacks images to aid the information. Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images.&lt;br /&gt;
Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities.&lt;br /&gt;
Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references. The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;br /&gt;
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Week 5 &lt;br /&gt;
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--[[User:Z3418989|Z3418989]] ([[User talk:Z3418989|talk]]) 22:34, 26 August 2014 (EST)&lt;br /&gt;
Hi guys &lt;br /&gt;
After discussing in lab last week we tried to divide the categories and work as following; &lt;br /&gt;
* skeletal and cartilaginous development - Joel&lt;br /&gt;
* muscular development - Gowtem&lt;br /&gt;
* overall skeletal and muscular arrangement macroscopically - Danny &lt;br /&gt;
What do you guys think about addressing these topics as well &lt;br /&gt;
* Historical findings&lt;br /&gt;
* Abnormalities &lt;br /&gt;
* New findings&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3418779|Z3418779]] ([[User talk:Z3418779|talk]]) 12:44, 27 August 2014 (EST)&lt;br /&gt;
Great idea m8 Danny can probably also do abnormalities, remember to post any articles of particular relevance to New/historical findings. To complete after main content assembled&lt;br /&gt;
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--[[User:Z3418779|Z3418779]] ([[User talk:Z3418779|talk]]) 01:02, 28 August 2014 (EST)&lt;br /&gt;
I would suggest that we narrow down the topic to focusing on the appendicular musculoskeletal system, so that;&lt;br /&gt;
*To make work load more managable&lt;br /&gt;
*To avoid the multiple highly specialised and irregular muscles/bones of the head&lt;br /&gt;
*The muscles I would suggest to include in are all muscles which have attachments to the appendicular skeleton including axioappendicular muscles (petoralis major, pectoralis minor, subclavious, serratus anterior, Latissimus Dorsi, Traps, levator scap, rhomboid major and minor.&lt;br /&gt;
*Joints and tendons are included in the musculoskeletal system, we should about wether we want to have a section for them.&lt;br /&gt;
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--[[User:Z3418779|Z3418779]] ([[User talk:Z3418779|talk]]) 09:05, 31 August 2014 (EST)&lt;br /&gt;
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Hi guys just posted the topics of abnormalities of muscle and skeletal system im gonna talk bout and references of relevant articles to the topics. Sorry for being late btw&lt;br /&gt;
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--[[User:Z3418779|Z3418779]] ([[User talk:Z3418779|talk]]) 14:57, 9 September 2014 (EST)&lt;br /&gt;
Disregard the rest of the stuff I said in earlier discussions, I believe that to make it significantly easier we just do muscular system. I will Reformat everything to make it make sense.&lt;br /&gt;
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--[[User:Z3418989|Z3418989]] ([[User talk:Z3418989|talk]]) 01:51, 10 September 2014 (EST) &lt;br /&gt;
Yeah completely agree, I think focusing on the muscular system would be much easier than doing both. Appendicular muscles sounds good - so muscles of limbs. Could divide it into upper and lower limbs. May have to talk about bone/cartilage a bit to describe how the muscle forms around it. Maybe how developing of muscles in embryonic development is important and eventually affects origin and insertions and actions of muscles when fully developed.&lt;br /&gt;
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--[[User:Z3418779|Z3418779]] ([[User talk:Z3418779|talk]]) 12:56, 17 September 2014 (EST) This link shows a very good description of myogenesis; http://books.google.com.au/books?id=1ZRCMRXbbwoC&amp;amp;pg=PA38&amp;amp;lpg=PA38&amp;amp;dq=primary+secondary+myofibers&amp;amp;source=bl&amp;amp;ots=RSRcVVe5xr&amp;amp;sig=eDJBF_3qkYzA8WSin1tnbzT2xYY&amp;amp;hl=en&amp;amp;sa=X&amp;amp;ei=OegYVL_UHpOB8gWMxoDYAw&amp;amp;ved=0CCoQ6AEwAw#v=onepage&amp;amp;q&amp;amp;f=false&lt;br /&gt;
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--[[User:Z3418989|Z3418989]] ([[User talk:Z3418989|talk]]) 12:27, 20 September 2014 (EST)&lt;br /&gt;
Ill add a bit more on embryonic muscle development guys&lt;br /&gt;
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--[[User:Z3418779|Z3418779]] ([[User talk:Z3418779|talk]]) 22:30, 6 October 2014 (EST)&lt;br /&gt;
Here are some article which would probably be helpful&lt;br /&gt;
Nrk2b-mediated NAD+ production regulates cell adhesion and is required for muscle morphogenesis in vivo: Nrk2b and NAD+ in muscle morphogenesis&lt;br /&gt;
Coexpression of two distinct muscle acetylcholine receptor a-subunits during development&lt;br /&gt;
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At the moment I have a general structure for tendon development and abnormalities will add to wiki tommorrow.&lt;br /&gt;
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the good indepth morphogenesis studies focus on gluteus maxximus, extrenal urethra spincter, tensor veli palatini very little are done of the other muscles, so will try to apply the conclusions from these studies to related skeltal muscles&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=150044</id>
		<title>User:Z3414515</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=150044"/>
		<updated>2014-10-14T18:06:36Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab 9 */&lt;/p&gt;
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&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
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Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
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Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
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Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
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Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
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Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
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Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
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Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
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Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
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==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
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[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
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[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
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==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
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==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
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Microarray Analysis&lt;br /&gt;
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Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
&lt;br /&gt;
Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
&lt;br /&gt;
Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Lab 9===&lt;br /&gt;
&lt;br /&gt;
'''Group 1'''&lt;br /&gt;
&lt;br /&gt;
* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
&lt;br /&gt;
* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
&lt;br /&gt;
* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
	&lt;br /&gt;
* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
	&lt;br /&gt;
* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
	&lt;br /&gt;
* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
	&lt;br /&gt;
* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
	&lt;br /&gt;
* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
&lt;br /&gt;
* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
&lt;br /&gt;
* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
&lt;br /&gt;
'''Group 2'''&lt;br /&gt;
&lt;br /&gt;
* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
&lt;br /&gt;
* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
&lt;br /&gt;
* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
&lt;br /&gt;
* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
&lt;br /&gt;
* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
&lt;br /&gt;
* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
&lt;br /&gt;
* I insist for you to put all the references in one place.&lt;br /&gt;
&lt;br /&gt;
* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
&lt;br /&gt;
'''Group 4'''&lt;br /&gt;
&lt;br /&gt;
* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
&lt;br /&gt;
* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
&lt;br /&gt;
* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
&lt;br /&gt;
* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
&lt;br /&gt;
* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
&lt;br /&gt;
* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
&lt;br /&gt;
* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 5'''&lt;br /&gt;
&lt;br /&gt;
* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
&lt;br /&gt;
* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
&lt;br /&gt;
* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
&lt;br /&gt;
* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
&lt;br /&gt;
* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
&lt;br /&gt;
* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
&lt;br /&gt;
* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
&lt;br /&gt;
* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
&lt;br /&gt;
* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
&lt;br /&gt;
'''Group 6'''&lt;br /&gt;
&lt;br /&gt;
* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
&lt;br /&gt;
* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
&lt;br /&gt;
* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
&lt;br /&gt;
* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
&lt;br /&gt;
* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
&lt;br /&gt;
* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
&lt;br /&gt;
* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
&lt;br /&gt;
* Thymus section only has little information so work more on this.&lt;br /&gt;
&lt;br /&gt;
* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
&lt;br /&gt;
* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
&lt;br /&gt;
* Gonad development section is well presented just add images to it. &lt;br /&gt;
&lt;br /&gt;
* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
&lt;br /&gt;
* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
&lt;br /&gt;
* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
&lt;br /&gt;
* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 7'''&lt;br /&gt;
&lt;br /&gt;
* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
&lt;br /&gt;
* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
&lt;br /&gt;
* Brain development section has a very good table and an image. &lt;br /&gt;
&lt;br /&gt;
* Spinal cord development section needs more information.&lt;br /&gt;
&lt;br /&gt;
* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
&lt;br /&gt;
* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
&lt;br /&gt;
* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
&lt;br /&gt;
* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
&lt;br /&gt;
* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
&lt;br /&gt;
'''Group 8'''&lt;br /&gt;
&lt;br /&gt;
* “Making Gains” is pretty funny but offcourse irrelevant to this project. &lt;br /&gt;
&lt;br /&gt;
* Your timeline needs a lot of work done as it is missing copious amounts of information.&lt;br /&gt;
&lt;br /&gt;
* Background embryonic development section is well detailed though it lacks images to aid the information.  Also molecular and cellular regulation of fetal myogenesis section is the same; it is well informed but lacks images. &lt;br /&gt;
&lt;br /&gt;
* Much more is needed on tendon development, second and third trimester muscular development, neonatal, mechanisms/structure of muscle fibres and abnormalities. &lt;br /&gt;
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* Over all very good in text citations for the development (top) section. References from the background section should be at the bottom of the page with other references.  The page mostly looks like a bulk of writing so include images where possible. A LOT more work is needed but I understand your situation as your group only has 2 members now so do as much as you can and GOOD LUCK!&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_7&amp;diff=150035</id>
		<title>Talk:2014 Group Project 7</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=Talk:2014_Group_Project_7&amp;diff=150035"/>
		<updated>2014-10-14T17:47:15Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Peer Reviews */&lt;/p&gt;
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&lt;div&gt;{{ANAT2341Project2014discussionheader}}&lt;br /&gt;
==Peer Reviews==&lt;br /&gt;
===1===&lt;br /&gt;
Good introduction but I would move what happens in the embryonic development to the “development” section. Also, don’t forget any references and in-text citations for this section. Maybe add more on what the page is about and what the readers should be expecting. Nonetheless, it gives a good background of the key organs in this system. The diagram for the timeline of development is quite complex. Try to explain what is happening in this diagram within the “development” section. For example, maybe try to have the same headings (cell multiplication, cell migration, etc.) as the diagram for the “development” subheadings.  Or, if you’re willing, make a timeline of your own. At least, you can make a simpler diagram where only relevant information is included. Good job on the “Visible Anatomical Details” table. &lt;br /&gt;
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On current findings, good choice on research articles. They’re very relevant to the topic and to the project as well. Maybe try to add some images if possible. Also, try to add some dates or anything to show how recent these studies are. There is a bit of imbalance in terms of the amount of content for each study but nonetheless, this section was written well. Good job! As for “abnormalities”, this section was done well. Each disease was written with lots of detail but very concisely. I do suggest adding more images that show the clinical manifestation of each disease. Also, don’t just focus on the manifestations of each defects. Try to look for current treatments or techniques on managing the abnormality. Also, maybe look for more references. &lt;br /&gt;
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On historic findings, where is it? There is a section on the Wikipage that has old books on embryology. It’s under the “Explore” tab and you’ll see “Historic embryo”.&lt;br /&gt;
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I’ve check all the images and there are no issues with them in terms of copyright. I can see that you tried to add captions to each photo, which is good but you can format the image in a way so that the caption is framed with the photo. Check out the [[https://embryology.med.unsw.edu.au/embryology/index.php/Help:Image_Tutorial#Image_Formatting| Image Formatting]] guide to do this. Overall, this page is very detailed and written very well. Just try to edit the page and make it look cleaner. &lt;br /&gt;
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===2===&lt;br /&gt;
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This project page is very nicely organised with the group clearly specifying what aspect of neural development they are covering, being the CNS. The use of headings and subheadings is done very neatly, however sections 1.1-1.5 could be subheadings for the larger title ‘system development’. The key points have been clearly described but there is no referencing throughout the ‘Introduction’, ‘Brain development’ and ‘Abnormalities’ sections. Most key points have at least some information on them which is good for this stage of the project; however some of the headings without could use some more work. &lt;br /&gt;
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The choice of content is highly appropriate and the use of diagrams and pictures help show the groups understanding of the project thus far. I particularly like the use of subheadings in this project as they make the page look neater and organised. The image showing the timeline of fetal neural development is good however perhaps it would be better to draw or make a timeline on the computer in order to show better understanding of the time course of fetal development. Most images that have been uploaded are also well referenced and when clicking onto them, it takes the reader to a page that has more information related to the image. The table to describe anatomical details is also done well and is important that such a key point is mentioned seeing as this is an anatomy course. &lt;br /&gt;
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I also really like how the ‘Current research, models and findings’ section is split into ‘Current research’ and ‘Future Research’, however it seems future research needs to be further looked into. The ‘Abnormalities’ section is done very well, with multiple abnormalities listed with images used to show each one. The bolding of several key words is seen and is helpful in showing understanding of some of the key points.  There are also no historic findings so try and find some information on that.&lt;br /&gt;
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Referencing is correctly done with most references being in one main section at the end, and ordered correctly. In-cite referencing is also done correctly. All images are correctly referenced with copyright information present and the student image template. I also like the way the current research findings sources have been referenced with the use of dot points assisting learning by not just presenting to the reader as a blob of information.&lt;br /&gt;
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Overall, well done group 7! Keep up the great work!&lt;br /&gt;
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===3===&lt;br /&gt;
The content looks well organized. The introduction could use a bit of work; it does a good job of introducing the CNS, but it should also mention all the other sections this page will cover regarding the topic. You might want to get rid of the using bold for brain and spinal cord, it just makes it look a little weird. Otherwise, a good embryonic developmental background is provided, it’s a good way to set the stage for when fetal development will commence from.&lt;br /&gt;
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The information is organized well, no chunky slabs of texts. But the use of dot points is a bit extensive; almost every section of the page has dot points or makes up the complete majority of the info presented. You might want to present some of it in paragraph form e.g. the abnormalities part, as that section can still be kept quite short and not be packed with text. As long as you mention what it is, how you get it/how it forms, some statistics and use a picture, the section can be still visually appealing.&lt;br /&gt;
The images are captioned ok, but there is a better way of doing it. In the command to input the image, continue the command with: |thumb|’whatever you want to write’], and the section in the apostrophes will be the caption under the picture (go into edit mode on another project page for a better idea, I might not have explained well). &lt;br /&gt;
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The use of the table is well done, makes all that info easily presentable, though I see the meninges development still needs to be done. The current research models and findings looks kind of messy with just the referenced PubMed article there. It might look better if you had the article name written in bold and a couple sentences underneath each to describe what the article was trying to achieve, like what has been done under current research. A couple pictures may be included to make it all more visually appealing and colourful.&lt;br /&gt;
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Overall, this was done well. You have a good amount of information, just try not to present it all in dot points. Make sure all your info is referenced in text, will all references displayed at the bottom of the page. Another note, try to organise your pictures in different areas of the page as well, as they are all currently on the left hand side. &lt;br /&gt;
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===4===&lt;br /&gt;
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This group page shows a good amount of work completed however there are quite a few sections that clearly still need some more info. A good introduction to the neural development and a accurate description of what will be covered. Although it seems to be missing the in text citations. The section on ‘development during fetal period’ is presented clearly and structured really well. The info is not too overwhelming and the use of dot points for this section is great as neural development is quite complex.  There’s a good identification of images and the use of in text citations.  The brain development section is written really well with enough detail and it’s nice to see a table for the timeline of changes during each week. It does however seem to be a bit short, maybe that’s because it’s all in dot point form. It would be useful if the ‘brain, spinal cord and meninges development’ were combined under one heading, this might be a better way to structure it. Otherwise just keep each section separate but format the info into paragraph form. In the ‘current research’ section a thorough amount of info was provided. It seems as though it hasn’t been finished and more info will be added later that will be great. The abnormalities content is sufficient and well organised. Just consider using more in text citations in this section, add some more images and complete all the sub headings.&lt;br /&gt;
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Finally a good effort in this project page, it is structured well and the info provided is easy to understand. However it needs some more research and content to fill all the sub headings in order for it to be finished. Some suggestions that may be considered include; having all the references under one main heading at the end of the page. The use of more in text citations in some of the paragraphs throughout the whole page would be effective. There is an adequately amount of images already shown, so maybe the use of videos or drawings would also be good especially in the abnormalities section and current research.  The key is to focus on filing the info and then just making a few adjustments in terms of formatting. Otherwise the page is set out well , just needs a little more work. The page will look really great once completed. Good luck ☺&lt;br /&gt;
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===5===&lt;br /&gt;
This page is organized well, all the headings and subheadings are thought through. Although, I’m unsure while the sections brain and spinal cord are in bold? The development during fetal period image lacks the necessary “student template” at the bottom of the description summary and I was unable to open the link http://www.nichd.nih.gov/publications/pubs/acute/images/p44.gif.&lt;br /&gt;
Otherwise, all the other images uploaded on the page look really good and are referenced correctly.  &lt;br /&gt;
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The table under the section brain development is very brief, and expansions on the content will allow for a better understanding of the content. Adding images to appear after the table will also add to the appearance of the page and give it a cleaner look. &lt;br /&gt;
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The spinal cord and menegies development have been left untouched and the current research models have no content, just pubmed references. I understand the current research models are probably the hardest part of the assignment, but the content appears to be quite good, the formatting of the section could be improved by following the structure Mark uses. You could look at the other group projects as examples. &lt;br /&gt;
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In regards to referencing, there are no in-text citations for the first two subheadings. I would also like to recommend just adding a final list of references at the bottom of the page, as it looks much neater. &lt;br /&gt;
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The abnormalities section is done well. But try to minimise the use of dot points as this section lacks any structured paragraphs. It use of images are great, although there is an image that appear to have been removed and as a result, there is a broken link. &lt;br /&gt;
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Overall, great job so far!&lt;br /&gt;
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===6===&lt;br /&gt;
This is a really good project so far. The introduction is really well done and I especially like that you have included a diagrams in it. The brain development is good, however I’m not completely sure about the dot points. It would look better if they were not there.&lt;br /&gt;
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Well done with the images that you have got there they all appear to be well described and referenced when you click on them. Only problem with the images is that there is a lack of them. It appears that there is an imbalance between written information and images tipping in favor of the information. I think it would be a good idea to add some more images to elicit more excitement in the page. Student images are a good idea as they highlight that it is a student project and make it more interesting for the viewer. &lt;br /&gt;
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The current research models and findings shouldn’t be left like it is at the moment. You will need to go into more detail and reference properly. While on referencing it is important that you put all your references at the bottom of the page. You only have 20 at the bottom at the moment and it is clear that you have used many more than twenty. Also you need to add in text citations so that we know exactly where you have got your information from. &lt;br /&gt;
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The current research part is good with plenty of information, but again look at adding more images to make it a bit more interesting. There are obviously some parts that you need to finish off which I’m sure your aware of. &lt;br /&gt;
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Overall it is a really good project with the potential to be excellent because of the amount of effort you have put into the research. Just make sure you change your references so that they are all down the bottom and have in text citations, add more images and maybe student images as well to make your page more presentable. Very well done so far and good luck with finishing the project off. &lt;br /&gt;
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===7===&lt;br /&gt;
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In this review I intend to highlight the merits of your project and suggest some areas for improvement in light of the marking criterial provided. &lt;br /&gt;
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The introduction provides the perfect preface for your project, it serves to summarise the topic and highlight the areas that you will be addressing.&lt;br /&gt;
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In the first section you have discussed fetal development of the neural system in great detail. I feel that a lot of research has gone into the collection and presentation of this date. The diagrams have been appropriately selected. Each image really ties in with the content and helps explain that stage development; I particularly like the diagram summarising the cell migration. In addition the images are well referenced. In the link you provide a brief description of the image and effectively explain the meaning of all the abbreviations. &lt;br /&gt;
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The topics addressed under the heading of current seem quite interesting. The project really succeeds in providing insight into this new MIR technology, a technology that will certainly allow us to build on current knowledge of fetal neural development. I see that the heading of future research has not been completed. However I feel that this is a very interesting sub heading and shows a clear aspiration to go beyond the scope of the course. &lt;br /&gt;
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A number of abnormalities have been addressed. I only suggest that you ensure that each of these subheading is addressed for each abnormality. Description; Epidemiology; Cause and possible Treatments, an image would be good too. &lt;br /&gt;
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All the content on this page is well written. I feel that all the subheadings are relevant, though some sections are not complete. The only major drawback of your project is that, at this point the area of historic findings has not been addressed at all. Make sure you address this area.&lt;br /&gt;
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===8===&lt;br /&gt;
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I believe the introduction of this page is excellent. A good choice of appropriate headings and subheadings. The addition of images would just add to the presentation of the introduction.&lt;br /&gt;
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The development section of this page is excellent! There is very informative, easy to follow and well-presented. There is clear evidence of significant scientific research and correct referencing. The choice and use of graphs and diagrams is excellent and does indeed add to the overall understanding of this section. I do believe, however, that this section could be included with the use of more tables? (Eg. The first four bolded subheadings)- but this is only a suggestion. Excellent nevertheless. Really enjoyed the ‘Visible anatomical details’ table.&lt;br /&gt;
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The current research section is a bit lacking in detail and appropriate choice of pictures. There is a good choice of subheadings and references though. The first included study is excellent though and should serve as a benchmark for the other remaining studies.&lt;br /&gt;
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The historic findings section is not presented on the page yet? I cant seem to find this section on your page. &lt;br /&gt;
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The abnormalities section is excellent, well presented and well researched. There is a very good use of subheadings and an excellent varying amount of abnormalities/defects included. The use of dot-points is effective, as well as, the accompanying pictures- really aids in understanding. This section, however, needs to be correctly referenced and cited. The other remaining abnormalities should be finalised (although I believe not all of the abnormalities should be discussed in great detail!). Great work, overall.&lt;br /&gt;
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===9===&lt;br /&gt;
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Overall, the project contains a decent amount of content as it is, split up into appropriate subheadings, considering the large scope of the nervous system. The introduction provides a succinct description of the CNS, however including an outline of what topics the page intends to cover would be good to orient a reader that approaches the page for the first time. The descriptions of the brain and spinal cord are well-written, however require in-text citations and some words need not be capitalised e.g midbrain, hypothalamus. These can be easily fixed with proof-reading and further editing.&lt;br /&gt;
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The use of an image to illustrate fetal development was a very good idea; although the diagram is itself seems complicated, it can be explained well with the accompanying text beneath. The segmentation of the timeline into 4 different parts made it easier to follow, although I would consider placing the images on the right hand side of the page to reduce the vertical length of the page and the scrolling required to navigate through it. The section on ‘brain development’ contained some relevant information, formatted in dot points which improves readability, however in-text citations are needed to allow the reader to source the information if required. The use of the table in this part was effective also; it was concise and straight to the point. &lt;br /&gt;
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Although the brain development section was very well detailed, there was no information in the spinal cord and meninges sections; with further research, these need to be evened out, along with the current findings section which is just references at this stage, but still a good start to finding sources of information. The section on current research is well-detailed and contains a lot of information too, which is good to see. Fiinally, I thought the section on abnormalities was very well done, using subheadings to segment the content. The use of dot points allowed the information to be easily read off the page, and use of images to accompany them helped the reader to visualise the conditions. There is one image however that has been incorrectly uploaded; consulting Dr Hill’s Wiki help page can remedy this. Also, the placement of all references under one list at the end of the page was effective in neatening it up, that was very well done too. &lt;br /&gt;
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Overall, the project’s content has been well-researched and there is evidence of good teamwork and communication. Perhaps the use of some student-drawn images and inclusion of a relevant video may be areas of improvement. &lt;br /&gt;
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===10===&lt;br /&gt;
This project is coming along quite nicely! The introduction is very thorough and provides a really sound basis for the topics which you covered. I enjoyed the use of diagrams in your introduction- although I admit your flow diagram was very scary! I think you should be a bit more clear in your timeline of the human neural development – it took me a moment to figure out what was happening, so it may be a better idea to put all this information into a table. &lt;br /&gt;
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The images that you have used are great as they are relevant and provide interest to your project page. The referencing on them appears consistent and there doesn’t appear to be any copyright issues- so I think you should include a few more diagrams, just to make your message even clearer. &lt;br /&gt;
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The current research models could do with some reformatting. I don’t think it is a good idea to put the references at the start, and secondly it seems like your work is not so well structured. I think if you included some bullet points in your work, it would greatly aid the clarity. The abnormalities is off to a good start, I see that it is well researched but you want to consider adding some more pictures or diagrams just to make it a bit more visually appealing. Overall this project is off to a good start, I think it may be a good idea to leave all your references until the end just to make your work more cohesive.  &lt;br /&gt;
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===11===&lt;br /&gt;
Very good introduction! Very informative and gives a great jist as to what the project will be about. The developmental timeline is very well done and easy to comprehend and understand.  You should add a lot more pictures in general to the whole page, there’s a lot of information and is organised nicely. &lt;br /&gt;
I feel the usage of dot points is a bit excessive, maybe try to organise some of the information into paragraphs to make it match the wiki page style.  The references aren’t organised at the bottom of the page yet; maybe something for the group to start when the page is unlocked for editing? Some parts of the page still do need a lot of information still to be added.  &lt;br /&gt;
I think you could go more into detail with the brain development; maybe you could make sub sections for development of the cerebrum, cerebellum, brain stem etc to add more information.&lt;br /&gt;
I’ve noticed that there is an image that hasn’t been uploaded correctly; have a look at the page on how to upload pictures, I’ve found that using Mark’s tutorial has been really helpful when I was doing my page. Hope this helped!&lt;br /&gt;
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===12===&lt;br /&gt;
Introduction is a bit too focussed on anatomical division of brain and spinal cord, doesn’t address current/historical research or abnormalities. Change the word “website” to page or project. The embryonic development is explained well and should have its own subheading. Referencing is required for the whole of the introduction, Brain development and abnormalities sections. The Sections 1.1 through to 1.5 could be subheadings under the “system development” main heading.&lt;br /&gt;
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Image showing fetal development timeline is quite overly complex and captioning/referencing is required. Additional explanation of the timeline image narrowing the viewer’s focus onto key fetal development processes will provide greater clarity allowing them to relate the image to surrounding content. The 3 images included in the project also are absent of referencing/captions present on the project page, though info after clicking on the image is great. Brain development information is in-depth and well presented(great use of table), the Spinal Cord and Meninges section have content yet to be added. There is an unusual caption [11] at the end of brain development which should be removed. Like the focus on anatomical structures. &lt;br /&gt;
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There is an absence of historical research which could be found searching on Pub Med for studies completed before a certain date(1970 for example). Current Research content is sufficient. Removal of the different types of dot-points, with addition of images would make the section more attractive.Abnormalities content is great for sections covered, removal of surplus abnormalities and “500px” at the bottom of the section is need unless they are still to be added to.&lt;br /&gt;
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===13===&lt;br /&gt;
The page had plenty of detail in some of the sections especially in the ‘Abnormalities’ section. This section in particular could benefit from the use of in text citation to support the text and some images to give a visual representation of the information. It is clear that it is not yet finished so it when the rest of the abnormalities are completed I think that this could be a strong point of your page.&lt;br /&gt;
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The ‘Current Research Models and Findings’ section has a good selection of articles but some subheadings need to be explained (e.g. ‘Future Research’). If possible, it might be beneficial to include some images break up this section but the summaries of most subheadings were very good. I think this page needs a ‘Historic Findings’ heading with the relevant information. A good place to start is to look under the ‘Historic Embryo’ tab for information. &lt;br /&gt;
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Overall this page contained some good information but still needs some work. Focus on including a ‘Historic Findings’ subheading and in text citations to support your text. &lt;br /&gt;
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===14===&lt;br /&gt;
Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing.&lt;br /&gt;
Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
Brain development section has a very good table and an image.&lt;br /&gt;
Spinal cord development section needs more information.&lt;br /&gt;
Meninges development section is empty so research needs to be done as soon as possible.&lt;br /&gt;
Current models and findings section just has references so do start to write on what those research articles say.&lt;br /&gt;
Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information.&lt;br /&gt;
Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on.&lt;br /&gt;
Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;br /&gt;
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--[[User:Z3418981|Z3418981]] ([[User talk:Z3418981|talk]]) 14:21, 16 August 2014 (EST) Hey everyone,&lt;br /&gt;
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What's everyone's ideas about doing the neural system for our project? there are lots of interesting Neurologic deficits that we could talk about!!!&lt;br /&gt;
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--[[User:Z3419587|Z3419587]] ([[User talk:Z3419587|talk]]) 23:25, 16 August 2014 (EST) That's a good idea. Neural system is a complex structure and it should be fun to work on it! Any other ideas?&lt;br /&gt;
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--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 23:51, 19 August 2014 (EST)&lt;br /&gt;
I talked to Yas before, sorry couldnt respond faster haha. Agree that Neural system would be interesting to research :p&lt;br /&gt;
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Do you guys have facebook as well? It might be an additional way to communicate&lt;br /&gt;
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--[[User:Z3422484|Z3422484]] ([[User talk:Z3422484|talk]])&lt;br /&gt;
I also agree on this topic being quite interesting as well&lt;br /&gt;
--[[User:Z3418981|Z3418981]]&lt;br /&gt;
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--[[User:Z3418981|Z3418981]] ([[User talk:Z3418981|talk]]) 10:54, 25 August 2014 (EST) hey guys it's yas! so we each need to choose one of the following:&lt;br /&gt;
Review the neural system development during the fetal period.&lt;br /&gt;
Identify current research models and finding.&lt;br /&gt;
Identify historic findings.&lt;br /&gt;
Identify abnormalities that can occur in this system during fetal period.&lt;br /&gt;
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--[[User:Z3419587|Z3419587]] ([[User talk:Z3419587|talk]]) 21:07, 25 August 2014 (EST) Thanks! This is vivian. Can I do &amp;quot;the review of the neural system development during the fetal period&amp;quot;? Or if anyone wants to do this section?&lt;br /&gt;
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--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 12:07, 26 August 2014 (EST)&lt;br /&gt;
Hey guys, Can i do historic findings for fetal neutral system development :) - Sean&lt;br /&gt;
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--[[User:Z3419587|Z3419587]] ([[User talk:Z3419587|talk]]) 17:47, 26 August 2014 (EST)I have put some subtitles to give a brief structure to our webpage, feel free to change them if you want!&lt;br /&gt;
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--[[User:Z3418981|Z3418981]] ([[User talk:Z3418981|talk]]) 17:51, 26 August 2014 (EST) sure and I'll do the abnormalities - Yas&lt;br /&gt;
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--[[User:Z3419587|Z3419587]] ([[User talk:Z3419587|talk]]) 18:25, 26 August 2014 (EST) hey Yas, see if this helps. &amp;lt;pubmed&amp;gt;25007063&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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--[[User:Z3418981|Z3418981]] ([[User talk:Z3418981|talk]]) 21:14, 26 August 2014 (EST) Thanks Vivian!! the article is very helpful! and the page looks really good too :)&lt;br /&gt;
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--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 20:18, 26 August 2014 (EST)&lt;br /&gt;
Hey guys, I think the last entry from my section will help alot in the ''Development'' section for our project :) - Sean&lt;br /&gt;
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&amp;lt;pubmed&amp;gt;17848161&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3419587|Z3419587]] ([[User talk:Z3419587|talk]]) 23:14, 26 August 2014 (EST) That's true! thanks Sean :) - vivian&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3422484|Z3422484]]--[[User:Z3422484|Z3422484]] ([[User talk:Z3422484|talk]]) 12:50, 27 August 2014 (EST)&lt;br /&gt;
Hey guys, this is a useful article for the abnormalities area &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24664314&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 23:55, 1 September 2014 (EST) nice one :D&lt;br /&gt;
How are you guys going with your sections?&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 12:58, 17 September 2014 (EST) &amp;lt;pubmed&amp;gt;10226791&amp;lt;/pubmed&amp;gt; maybe for development&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 21:12, 20 September 2014 (EST) http://www.ehd.org/cache/pdf/fd7e47f291dded855c38ffb3418fbdc8/timeline.pdf&lt;br /&gt;
&lt;br /&gt;
something which might help us figure out a timeline structure&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3374116|Z3374116]] ([[User talk:Z3374116|talk]]) 11:56, 24 September 2014 (EST) http://discovery.lifemapsc.com/library/review-of-medical-embryology&lt;br /&gt;
A textbook which has great information on the development of the CNS during the fetal period&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3422484|Z3422484]] ([[User talk:Z3422484|talk]]) 11:35, 8 October 2014 (EST)&lt;br /&gt;
Hey guys i will be adding a few extra research articles to the current research tab&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3422484|Z3422484]] ([[User talk:Z3422484|talk]]) 11:35, 8 October 2014 (EST)&lt;br /&gt;
Also is there anything else anyone needs help on as well?&lt;br /&gt;
&lt;br /&gt;
--[[User:Z3422484|Z3422484]] ([[User talk:Z3422484|talk]]) 12:09, 8 October 2014 (EST)&lt;br /&gt;
Forgot to mention that I'll also be adding spinal cord abnormalities&lt;br /&gt;
&lt;br /&gt;
For Historial Research and Findings&lt;br /&gt;
&amp;lt;pubmed&amp;gt;19339620&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;8005032&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;9311417&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17848161&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;12768653&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17060425&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;21042938&amp;lt;/pubmed&amp;gt; for brain de&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
abnormalities&lt;br /&gt;
&amp;lt;pubmed&amp;gt;12454899&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25007063&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;16530991&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;7504639&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;19651588&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25135350&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25128525&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24397701&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
----&lt;br /&gt;
&lt;br /&gt;
*Good start on the introduction. Maybe have it used to explicitly state what your entire page will be covering rather than just a background on what the CNS is. &lt;br /&gt;
*You're missing references for the huge chunks of information in the introduction section&lt;br /&gt;
*The image of the timeline of development seems overly complex and I can't tell if you've explained it. If it's not relevant, maybe just come up with your own concise table of what happens during the course of development&lt;br /&gt;
*Maybe think of re-creating some simpler images by hand and uploading them. That way you can choose to focus on what you actually need from the image to show what you're explaining&lt;br /&gt;
*Include the years of when your current findings were discovered&lt;br /&gt;
*For the &amp;quot;abnormalities&amp;quot; section, as there are many, maybe the amount of detail you've included for the first couple of ones isn't needed, but of course, use your own discretion to how much is relevant. Otherwise, the bullet points are a good way to simplify information &lt;br /&gt;
*Collate all your references in the bottom from all the separate sections&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
	</entry>
	<entry>
		<id>https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=150032</id>
		<title>User:Z3414515</title>
		<link rel="alternate" type="text/html" href="https://embryology.med.unsw.edu.au/embryology/index.php?title=User:Z3414515&amp;diff=150032"/>
		<updated>2014-10-14T17:44:13Z</updated>

		<summary type="html">&lt;p&gt;Z3414515: /* Lab 9 */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;==Lab Attendance==&lt;br /&gt;
Lab 1 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 12:46, 6 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 2 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 13 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 3 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:07, 20 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 4 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:14, 27 August 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 5 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:13, 3 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 6 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:17, 10 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 7 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:23, 17 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 8 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:09, 24 September 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
Lab 9 --[[User:Z3414515|Z3414515]] ([[User talk:Z3414515|talk]]) 11:34, 8 October 2014 (EST)&lt;br /&gt;
&lt;br /&gt;
==Practice==&lt;br /&gt;
http://www.ncbi.nlm.nih.gov/pubmed&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed PubMed]&lt;br /&gt;
&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118885/ Pmid4118885]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;4118885&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==My Type in a Group==&lt;br /&gt;
===Teamworker===&lt;br /&gt;
A Teamworker is the oil between the cogs that keeps the machine that is the team running smoothly. They are good listeners and diplomats, talented at smoothing over conflicts and helping parties understand one other without becoming confrontational. Since the role can be a low-profile one, the beneficial effect of a Teamworker can go unnoticed and unappreciated until they are absent, when the team begins to argue, and small but important things cease to happen. Because of an unwillingness to take sides, a Teamworker may not be able to take decisive action when it is needed.&lt;br /&gt;
&lt;br /&gt;
==Lecture Reviews==&lt;br /&gt;
===Lecture 1===&lt;br /&gt;
Course introduction for embryology as well as the history of embryologists and how the diagrams of embryo changed through time as more advance technology was available. Guidelines to the course was mentioned as well as the assessments and type of work expected for this course.&lt;br /&gt;
===Lecture 2===&lt;br /&gt;
In the fertilization lecture the most interesting concept for me was the polar bodies and the sry gene. Every other concepts such as gametes, mitosis, meiosis and fertilization was familiar. Polar bodies and the sry gene was a completely new idea for me. Meiosis 1 releases first polar body and meiosis 2 releases the second polar body. Sometimes meiosis 1 releases first and third polar bodies.&lt;br /&gt;
&lt;br /&gt;
==Individual Assessments==&lt;br /&gt;
===Lab 1===&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25089626/ Pmid25089626]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25089626&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
Microarray Analysis&lt;br /&gt;
&lt;br /&gt;
Raw data on Affymetrix GeneChip HGU133 were obtained from the ArrayExpress for human preimplantation embryos. The invariant set normalisation method was used and via using the Li-Wong method, the expression values were extracted from PM-values. The arrays were normalised independently and Li-Wong method was applied to all normalised arrays to get a summary of the expression measurements. Using Bayesian approach, differential expression between the consecutive development stages was analysed.&lt;br /&gt;
&lt;br /&gt;
Embryo Collection&lt;br /&gt;
&lt;br /&gt;
FVB/N mice were kept for 12 hours under light/dark cycle and were fed regularly. A Pregnant Mare’s Serum (5 IU) was injected into a 4-7 weeks old female. After 44 hours a human chorionic gonadotropin (5 IU) injection was given. The females then mated with the FVB/N strain studs (males). 19-21 hours later the females were sacrificed and the oviducts were collected. Oocytes were collected. The embryos were then cultured in KSOM medium.&lt;br /&gt;
&lt;br /&gt;
Gene expression analysis&lt;br /&gt;
&lt;br /&gt;
Extraction of RNA from mouse unfertilised oocytes using Arcturus PicoPure RNA isolation kit was done. Agilent Bioanalyser was used to measure the RNA quality and concentration. One embryo yielded 128 pg of total RNA on average. For each final protocol, three biological replicas of all the stages were collected.&lt;br /&gt;
&lt;br /&gt;
TaqMan Array Cards analysis&lt;br /&gt;
&lt;br /&gt;
RQ Manager version 1.2.2 (Applied Biosystems) were used to analyse Ct values. Hprt1 and Psmb6 were the endogenous controls which were used for normalisation.&lt;br /&gt;
&lt;br /&gt;
Expression analysis from public sequencing dataset&lt;br /&gt;
&lt;br /&gt;
Gene Expression Omnibus database was used to obtain the normalised RPKM values for human and mouse pre-implantation stages. The p-values were calculated for the pairs i.e. oocytes and 4-cell blastomeres and etc. The p-values below 0.05 were significant. In human and mouse, the average values for each stage between embryos in the same biological stages were calculated.&lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Analysis of two independent human pre-implantation microarray datasets were done in order to define the genes with consistent gene expression profiles between embryo stages. The probes which had significant changes in both datasets were considered for further analysis. Probes in the “Up-down” cluster were up regulated whereas the probes in “Down” cluster were down regulated. Genes were selected from each cluster “Up”, Up-down” and “Down” for analysis of expression profile of mouse pre-implantation embryo by qPCR. A gene was included if its ortholog was found in any of the following samples in MGI: oocyte, unfertilized oocyte, fertilized oocyte, 2-cell embryo, 4-cell embryo, 8-cell embryo, 16-cell embryo, blastocyst. In the mouse, 55 genes with orthologs were selected for gene expression profiling. Also expression patterns of the selected genes in the mouse were studied. The maternal gene expression profile was seen to be shared in more than half of the mouse orthologs for genes “Up” and “Up-down” clusters. All the PRAME and most SSX, MAGEA and GAGE family members in human microarray were of “up-down” cluster. However, in the pre-implantation human embryo, the selected families’ genes had dynamic expression profiles.&lt;br /&gt;
&lt;br /&gt;
'''Reference:'''&lt;br /&gt;
[http://www.ncbi.nlm.nih.gov/pubmed/25071849/ Pmid25071849]&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;25071849&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''Method summary'''&lt;br /&gt;
&lt;br /&gt;
This study was performed in Assisted Reproduction of Wuhan Union Hospital from January 2012 to December 2012. A total of 1891 cycles were used which contained 1150 fresh embryo transfers and 741 frozen-thawed embryo transfers. Cleavage-stage or blastocyst-stage was composed in 1150 women. Also 741 women were divided into cleavage-stage or cleavage-stage extended blastocyst culture or blastocyst-stage transfer. A GnRH agonist protocol was used in all the cycles. An injection of 10000 units of HCG was given to two or more follicles when they reached 18mm in diameter and then 34-36 hours later an ovum pick up was performed. After OPU, 4-6 hours later in vitro fertilisation was performed. The assessment for the embryo was based on the rate of development and morphology. All the good embryos were cryopreserved through vitrification. The number of implantations was observed as the number of sacs. Using the SPSS software, all the statistical calculations were performed. &lt;br /&gt;
&lt;br /&gt;
'''Result summary'''&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients less than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 52.7%&lt;br /&gt;
*Fresh blastocyst transfers: 35.88%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 35.29%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 47.75%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 59.8%&lt;br /&gt;
&lt;br /&gt;
Clinical pregnancy rates for patients more than 35 years of age:&lt;br /&gt;
*Fresh cleavage-stage embryo transfers: 41.24%&lt;br /&gt;
*Fresh blastocyst transfers: 26.92%&lt;br /&gt;
*Frozen-thawed cleavage-stage embryo transfers: 11.32%&lt;br /&gt;
*Post thaw cleavage-stage extended blastocyst culture transfers: 46.15%&lt;br /&gt;
*Frozen-thawed blastocyst transfers: 55.8%&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are very good paper summaries. (5/5)&lt;br /&gt;
&lt;br /&gt;
===Lab 2===&lt;br /&gt;
[[File:E18.5_developing_kidney_expressing_Pygo1_and_Pygo2.jpg|300px]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''E18.5 developing kidney expressing Pygo1 and Pygo2'''&lt;br /&gt;
&lt;br /&gt;
Expression patterns of Pygo1 and Pygo2 proteins in the cortex of E18.5 kidney was determined using immunofluorescence. The location of both Pygo1 and Pygo2 were in the nucleus with the colour red. Both genes are expressed widely where in all the components of the developing kidney, a signal is detected. However their were high levels of stromal cell compartment(arrows). Original magnification x200&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] ([[User talk:Z8600021|talk]]) 16:14, 21 August 2014 (EST) You have not explained in the file information or on this current page what Pygo1 and Pygo2 actually are? The correct information was associated with the image summary box, you do not need to repeat copyright and student template here. Images when used in your project will though include a reference link. (4/5)&lt;br /&gt;
&lt;br /&gt;
'''Reference'''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;17425782&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
© 2007 Schwab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.&lt;br /&gt;
&lt;br /&gt;
{{Template:Student Image}}&lt;br /&gt;
&lt;br /&gt;
===Lab 3===&lt;br /&gt;
These are only the tip of the ice burg journal articles but further details will be mentioned later throughout this course as my path comes closer to its destination.&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23799566&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22750256&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23720330&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
--[[User:Z8600021|Mark Hill]] These are relevant articles, but you have not identified your project sub-section or explained in a sentence why you have selected these references (4/5).&lt;br /&gt;
&lt;br /&gt;
===Lab 4===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify a paper that uses cord stem cells therapeutically and write a brief (2-3 paragraph) description of the paper's findings.&lt;br /&gt;
'''&lt;br /&gt;
&lt;br /&gt;
''Therapeutic effect of human umbilical cord-derived mesenchymal stem cells in rat severe acute pancreatitis.''&lt;br /&gt;
&lt;br /&gt;
A technique used called flow cytometry illustrated that expressions of CD45, CD34, CD11b, CD19 and HLA-DR were lacking in MSCs derived from umbilical cord. However high expressions of CD44, CD73, CD90 and CD105 were observed. MSCs have the capability of osteogenesis, adipogenesis and chondrogenesis which was observed from the experiment of induction differentiation. &lt;br /&gt;
&lt;br /&gt;
In control group, there were no edema, bleeding, inflammatory cells and necrosis in the pancreatic lobules at different times. Pancreatic edema was immediately observed after surgery in SAP group. Expansion of alveolar system, infiltration of inflammatory cells and parenchymal bleeding was noticed one day after surgery. Pancreatic parenchymal necrosis weakened three days after the surgery. The merging of necrotic area was seen five days after the surgery followed by the observation of tubular complexes. In SAP+MSCs group, over time the pathological changes improved and small amount of fibrous tissue were observed. Pathological scores for SAP were higher than those of the control group with regards to pancreatic parenchymal bleeding and nercrosis, pancreatic edema and infiltration of inflammatory cells. &lt;br /&gt;
&lt;br /&gt;
After MSCs transplantation, apoptosis of pancreatic acinar cells reduced. In SAP group, large numbers of apoptosis cells in pancreas were noted. After MSCs transplantation, the apoptosis cells reduced in numbers since day 3. In SAP+MSCs group the number of apoptosis cells were lower than those in the SAP group on days 3 and 5.&lt;br /&gt;
&lt;br /&gt;
''Reference:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24294357&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. There are a number of developmental vascular &amp;quot;shunts&amp;quot; present in the embryo, that are closed postnatally. Identify these shunts and their anatomical location.'''&lt;br /&gt;
&lt;br /&gt;
There are three vascular “shunts” present in the embryo.  These are:&lt;br /&gt;
&lt;br /&gt;
•Foramen Ovale: an opening that allows blood to flow from right atrium to the left atrium. This opening is located in the interatrial septum. There is a valve that is associated with this opening during the fetal period to prevent back flow of blood. This shunt closes when the blood pressure in the atria increases due to the newborn beginning to breathe. &lt;br /&gt;
&lt;br /&gt;
•Ductus Arteriosus: is a short, muscular vessel which connects the pulmonary trunk and the aorta. Majority of the blood pumping into the pulmonary trunk from the right ventricle is therefore diverted into the aorta. Thus only enough blood reaches the fetal lungs to maintain the developing lung tissue. The pressure within the lungs drops dramatically as the newborn takes the first breath thus expanding both the lungs and pulmonary vessels. The smooth muscles in the wall of the ductus arteriosus constrict as the amount of oxygen increases hence sealing off the passage. &lt;br /&gt;
&lt;br /&gt;
•Ductus Venosus: a temporary blood vessel that originates from the umbilical vein this bypasses the fetal liver and goes directly to       the fetal heart.&lt;br /&gt;
&lt;br /&gt;
===Lab 5===&lt;br /&gt;
&lt;br /&gt;
'''Oesophagus Stenosis'''&lt;br /&gt;
&lt;br /&gt;
Oesophageal stenosis is the narrowing of the oesophagus which usually occurs in the distal third. The oesophagus needs recanlization at the end of the embryonic phase to be complete. Oesophagus stenosis is when this recanalization is incomplete hence creating a significantly narrow lumen. This occurs during the eight week of human embryologic development. Oesophageal stenosis may also occur due to lack of blood supply to the affected area or the lack of development of the blood supply to the affected area. Usually the oesophagus lengthens but when the mishap of recanalization happens, it results in shortened oesophagus which then leads to the stomach being displaced superiorly through the oesophageal hiatus.  &lt;br /&gt;
&lt;br /&gt;
''References:''&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;22470735&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[http://www.nature.com/gimo/contents/pt1/full/gimo6.html]&lt;br /&gt;
&lt;br /&gt;
[http://emedicine.medscape.com/article/837879-overview]&lt;br /&gt;
&lt;br /&gt;
===Lab 7===&lt;br /&gt;
&lt;br /&gt;
'''1. Identify and write a brief description of the findings of a recent research paper on development of one of the endocrine organs covered in today's practical.'''&lt;br /&gt;
&lt;br /&gt;
One of the findings was on cell cycle regulation. Genetic material is copied is S phase and then divides into two daughter cell which is M phase. Cell cycle is regulated by checkpoint mechanisms which are very crucial in order to maintain a normal regulation. Length of cell cycle varies significantly. During the development of the pituitary gland, proliferation progenitors exit from the cell cycle are marked by the Cdkn1c and Ccne. The intermediate lob is frequently affected which contains rudimentary in humans. Most pituitary adenomas are benign and sporadic though familiar types do exist. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24290346&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
'''2. Identify the embryonic layers and tissues that contribute to the developing teeth.'''&lt;br /&gt;
&lt;br /&gt;
The layers are vestibular lamina, distal lamina and these connect the developing tooth bud to the mouth’s epithelial layer.  Also the enamel is separated into four layers which are outermost consisting of dentin, outer enamel epithelium, inner enamel epithelium and stratum intermedium.&lt;br /&gt;
The tissues of teeth are hard tissues which include enamel and dentin, mineralised tissue, fused tissue, gingiva, pulpal tissue and soft tissues. &lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;20682455&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;23222990&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Lab 8===&lt;br /&gt;
&lt;br /&gt;
'''1. Provide a brief time course and overview of embryonic development of either the human testis or ovary. (2-3 paragraphs)'''&lt;br /&gt;
&lt;br /&gt;
Migration of mesonephric cells into the developing gonad and their proliferation appears to follow a well defined pattern. &lt;br /&gt;
&lt;br /&gt;
Simultaneous occurrence of three specific events characterize the formation of ovigerous cord. First is the basal lamina material patches increasing which become apparent at the outer margins of oogonia and pre-granulosa cell complexes. Second is the isolation of oogonia from each other by pre-granulosa cells developing cytoplasmic extensions. Third and final is the increase infiltration of medullary stroma/rete cells between cortical complexes. The end results consist of clusters of oogonia and pre-granulosa cells which form the cords and these are isolated from the ovarian stroma by a basal lamina. The development of ovigerous cords differ in species with delayed meiosis. In humans, the ovigerous cords are not clearly defined. The presence of membrane enclosed clusters of somatic and germ cells in all mammalian fetal ovaries, are supported by evidence however the timing and the development may vary due to interspecies. As the basal lamina seperates the ovigerous cords which contain the pre-granulosa cells and oocytes from ovarian stroma, the ovigerous cords are opened to the surface of the ovary. The presence of isolated or small clusters of large cells in the ovarian medulla has been reported to consist throughout the period of cord and follicle development. &lt;br /&gt;
&lt;br /&gt;
Development of cells within the ovigerous cords are based on three events which are initiation of germ cell meiosis, germ cell apoptosis and follicle formation. In humans, production of retinoic acid by ovarian is required for the meiosis to initiate. Retinoic acid is the key player in the initiation of meiosis. In humans, the development of meiosis and follicle progresses from inner and outer regions of the cortex. Germ cell proliferation rate decreases as the rate of germ cell death increases. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24741072&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;pubmed&amp;gt;24097381&amp;lt;/pubmed&amp;gt;&lt;br /&gt;
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'''2. Include an image from the historic genital embryology section of the online notes in your description.'''&lt;br /&gt;
[[File:Bailey329.jpg|left|300px|thumb| Transverse section of the ovary of a fox embryo]]&lt;br /&gt;
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===Lab 9===&lt;br /&gt;
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'''Group 1'''&lt;br /&gt;
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* The structure of this page looks good regarding the text and image ratio. &lt;br /&gt;
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* Stages of lung development table was very effective for me to grasp the contents and understand it effectively. However providing an image would aid in grasping the contents effectfully.&lt;br /&gt;
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* Under the recent findings section, most of the information is relevant though you should consider the biochemical aspect of it too. &lt;br /&gt;
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* Current models need more researching. Try including more journal articles for current models maybe. &lt;br /&gt;
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* Under historic findings, more detail is needed for the fetal lung development. Try to obtain more relevant articles on fetal lung development and integrate the information with your current information.&lt;br /&gt;
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* Abnormalities are described well and are detailed so WELL DONE!&lt;br /&gt;
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* Good use of images which makes it engaging and interesting. Although some images lack captions and few images are missing copyright.&lt;br /&gt;
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* Try to include in text citations and put together all the references in the end of the page. &lt;br /&gt;
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* Just fix up the references and in text citations also mention your sections of the page in the introduction and that’s it. &lt;br /&gt;
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* LOOKS REALLY GOOD SO FAR just needs to fix few minor things.&lt;br /&gt;
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'''Group 2'''&lt;br /&gt;
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* Very nice introduction. Keeps the reader engaged and outlines what the page is about specifically.&lt;br /&gt;
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* Historic findings have been untouched but do not worry I think you still have 1-2 weeks to complete this project. Try using pubmed and also it will be helpful to looks at Mark’s (course coordinator/convenor) historical textbooks/journal articles on his page.&lt;br /&gt;
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* Try having in text citations for the timeline. Also try making a table instead of dot points as well as use images if possible. Also try including a little more information in the timeline as this can give the reader a greater idea of what to expect.&lt;br /&gt;
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* Try including the years of when the current findings were discovered.  Also try to have some information on the molecular signals which drive the development of renal in fetus. &lt;br /&gt;
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* The abnormalities section is well researched and well organised though I suggest putting the references in the end of the page as a bulk. &lt;br /&gt;
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* Well use of images throughout the page. All the images were related to the topic and were very well put together in the text.&lt;br /&gt;
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* I insist for you to put all the references in one place.&lt;br /&gt;
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* Finally just fix few minor things and add information to the historic section then you will be done. Overall well done as the page is well organised and is not missing much in terms of contents.&lt;br /&gt;
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'''Group 4'''&lt;br /&gt;
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* Great progression on the table in text citation for it is missing. Also in the table for week 5 you have bullet points and for weeks 1-7 you have a different type of bullet point. Try keeping it consistent. &lt;br /&gt;
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* The diagram used to illustrate the genital development of different genders is very good and effective.&lt;br /&gt;
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* Current research and models section needs more pictures to help aid with the information. Under current models section, the hand drawn image is very good and effective in portraying the overview.  Also in the current research and model section, try using more than one reference. &lt;br /&gt;
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* Current findings section is currently empty but that’s ok as you still might have 1-2 weeks to finish the project. &lt;br /&gt;
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* Historic findings needs more images as it seems like a big bulk of text. However it is very well researched. &lt;br /&gt;
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* Abnormalities needs more pictures as it seems like a bulk of text. I suggest obtaining a picture for each abnormality you talk about if possible. This aids the readers’ understanding of that specific abnormality. Also ‘pictures say a thousand words’ so it would be great if you can include pictures. &lt;br /&gt;
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* All hand drawn images are great and clear to read and understand.&lt;br /&gt;
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* Your references from other sections need to be in the end of the page in a bulk.&lt;br /&gt;
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'''Group 5'''&lt;br /&gt;
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* Much more information on introduction is needed maybe. Also in text citations is needed. &lt;br /&gt;
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* EXCELLENT job on the overview development section. The table and the images are great especially. Great use to information and the corresponding images. One suggestion though, put in text citations. &lt;br /&gt;
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* Try to avoid repetitions as in the overview “this page” is repeated and in the table “a study” is repeated. Try being specific to which study you are referring to. &lt;br /&gt;
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* Well balance of text and images in the development overview section.  In text citations are needed and all the references would look better in the end of the page in a bulk.  &lt;br /&gt;
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* For your first research findings maybe obtain an image/s to aid the information. &lt;br /&gt;
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* Historic findings section is just a bulk of text. No images can be seen so if possible I suggest you add images to this section. Although it is VERY WELL researched.&lt;br /&gt;
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* VERY WELL DONE with the abnormalities section as each abnormality is well explained and has an image to accompany it. &lt;br /&gt;
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* Try not to use a lot of pictures and references from the Embryology website.&lt;br /&gt;
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* Over all this page is good but a lot of in text citation needs to be done and the references need to be in the end of the page in a bulk.&lt;br /&gt;
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'''Group 6'''&lt;br /&gt;
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* The introduction section is blank so I suggest you start on it as soon as possible.&lt;br /&gt;
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* I like how you have organised the sections in terms of each gland.&lt;br /&gt;
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* Pineal gland section requires in text citations and more information with the aid of an image. Spelling error for abnormalities. &lt;br /&gt;
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* Hypothalamus section needs more information and images. Good idea to use a table but it is incomplete. In text citations are needed throughout. &lt;br /&gt;
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* Pituitary gland section only has the timeline and references. It needs much more information and images with in text citations.&lt;br /&gt;
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* Thyroid section is a bit better but still is missing little information.&lt;br /&gt;
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* Parathyroid gland has a very good image and the information is well presented. Once again in text citations are needed.&lt;br /&gt;
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* Thymus section only has little information so work more on this.&lt;br /&gt;
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* Pancreas by far is a much better section compared to others as it consists of an image, table and a timeline. In text citation are missing.&lt;br /&gt;
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* Adrenal gland section is missing a little information and an image that’s all. Also in text citation is missing.&lt;br /&gt;
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* Gonad development section is well presented just add images to it. &lt;br /&gt;
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* Placenta section just has references. You need to start researching information on this.&lt;br /&gt;
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* Associated abnormalities section just has an incomplete table. &lt;br /&gt;
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* The page could use a bit more uniformity. Throughout the page, two different spellings are used for fetal (fetal and foetal). Try keeping the context consistent. &lt;br /&gt;
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* Overall I suggest you start researching more for your project as A LOT of work may be needed to be done. In text citation is crucial as you have noticed by my constant repetition for it. Recent findings and historic sections are missing. I suggest researching on pubmed under “(gland name) historic/research findings”. All the references will look better and more professional if it was in the end of the page in a bulk. There are some really good information and images on your page. If possible try adding hand drawn images too. You may only have 1-2 weeks to complete this project but I believe you can do it so good luck!&lt;br /&gt;
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'''Group 7'''&lt;br /&gt;
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* Introduction is well informed and written. Maybe write a bit more about what the page is about rather than just a background on the central nervous system. I suggest maybe putting up an image to aid the text. In text citations are missing. &lt;br /&gt;
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* Development during fetal period has great images to aid the information written so well done. Although I suggest not using bullet points a lot.&lt;br /&gt;
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* Brain development section has a very good table and an image. &lt;br /&gt;
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* Spinal cord development section needs more information.&lt;br /&gt;
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* Meninges development section is empty so research needs to be done as soon as possible. &lt;br /&gt;
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* Current models and findings section just has references so do start to write on what those research articles say. &lt;br /&gt;
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* Current research is well informed but images will help aid the information. Future research is blank which needs to be filled up with information. &lt;br /&gt;
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* Abnormalities section is quite good as the image and information relate to each other and the images help aid the information. A bit incomplete towards the end which you should write up on. &lt;br /&gt;
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* Overall, some of the images are a bit too complex so maybe try hand drawing some images in a simplified manner. All the references would look more professional and neat if it was at the end of the page in a bulk. Also historic findings section is missing so suggest you add that if possible. Good so far just missing bits and pieces of information which I am sure you can write up on within a week. Good luck!&lt;/div&gt;</summary>
		<author><name>Z3414515</name></author>
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