Talk:2009 BGD-B Lecture Sexual Differentiation
Development of the Genital System Dr Mark Hill Cell Biology Lab, SOMS Room G20 Wallace Wurth Bldg m.hill@unsw.edu.au UNSW Copyright Notice
Background
Notes
Fertilization
Week 1
Gastrointestinal Tract
Kidney
Endocrine
Urinary Bladder - early
Endoderm Yolk sac, yolk stalk, gastrointestinal tract Hindgut Allantois extending into connecting stalk
Movie: Hindgut - Urogenital Sinus Urinary Bladder - Septation Cloaca divided (week 6) Urorectal septum Posterior- rectum Anterior- urogenital sinus Continuous with allantois Apex of developing bladder Urachus Median umbilical ligament
Nephrons
Movie: Germ Cell Migration
Internal Genital Organs
All embryos form paired
Nephric duct
Mesonephric duct (Wolffian)
See kidney development
Paramesonephric duct (Mullerian)
Humans 7th week
Invagination of coelomic epithelium
Cord grows and terminates on urogenital sinus
Male Gonad (testes) secretes
Mullerian duct inhibitory factor (MDIF)
Causes regression of paramesonephric duct
Testosterone
Retains mesonephric duct
Female - opposite
Movie: Germ Cell Migration
SRY on Gonad Development Differentiation of Human Gonads Movie: Gonad Development Gonad Differentiation Overview Male Mesonephric Duct (st22) Movie: Bladder Fetal Testis Infant Ovary Ovary - Germ Cell Numbers External Genitalia
Genital Ligaments Movie: Gonad Descent Both male and female gonads descend See also Abnormalities - Cryptorchidism