Spermatozoa Chemotaxis: Difference between revisions

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| colspan=2|<html5media height="550" width="512">File:Spermatozoa chemotaxis PMID23183693.mp4</html5media>
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Sea Urchin Spermatozoa Chemotaxis

Modern version[1] of Lillie's historic 1902 sea urchin spermatozoa experiment.[2]


Chemotaxis is the attractive movement of an organism in response to a chemical stimulus, usually toward or "up" the chemical concentration gradient. Spermatozoa of other species respond to different chemical attractants. In human fertilization, this is probably progesterone released by glomerulosa cells surrounding and bound to the oocyte zona pellucida.


Kaubb's 2012 experiment[1] (on the left) shows the release of resact with a UV flash induces accumulation of sperm in the illuminated area while an annulus around the flash becomes depleted of sperm. After several seconds, the gradient dissipates because of resact binding and diffusion. (text from figure legend)


Resact - Causes stimulation of sperm respiration and motility through intracellular alkalinization, transient elevations of cAMP, cGMP and calcium levels in sperm cells, and transient activation and subsequent inactivation of the membrane form of guanylate cyclase.


Links: MP4 version | Fertilization | Spermatozoa Development | Sea Urchin Development | Movies


Reference

  1. 1.0 1.1 <pubmed>23183693</pubmed>| J Gen Physiol.
  2. <pubmed>17735765</pubmed>


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