Mouse Lymph Node Movie 5
Mouse_adult_lymph_node_05.jpg</wikiflv> | Adult Mouse Lymph Node - T cell Bi-directional traffic.
Bi-directional trafficking of an individual T cell across the sinus wall in a control axillary lymph node. |
Movies show lymphocyte traffic through adult lymph nodes. Cells were isolated from spleens and lymph nodes of BALB/c mice.
Adult Mouse Lymphocyte Motility | |||||||||||||||
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Transendothelial migration |
T cell zone | Medullary sinus | Sinus endothelial barrier | ||||||||||||
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Bi-directional traffic | Cross the sinus endothelial barrier |
T and B cell motility | T and B cell coupling | ||||||||||||
Mouse Immune Movies: Transendothelial migration | T cell zone | Medullary sinus | Sinus endothelial barrier | Bi-directional traffic | cross the sinus endothelial barrier | T and B cell motility | T and B cell coupling | T cell Elimination | Immune System Development | Mouse Development |
- Links: Immune System Development | Lymph Node Development | Lecture - Lymphatic Structure and Organs
References
Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I & Cahalan MD. (2005). Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. , 6, 1228-35. PMID: 16273098 DOI.
Cahalan MD & Parker I. (2008). Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu. Rev. Immunol. , 26, 585-626. PMID: 18173372 DOI.
Movie Source
Michael D. Cahalan, Professor and Chair, Department of Physiology and Biophysics, University of California, Irvine. Lab Two-photon imaging movies reproduced with permission of Prof. Cahalan.