Lecture - Integumentary Development
Introduction
The skin provides a barrier between ourselves and our environment (temperature, water, UV), and contains specializations in different regions including hair, nails, teeth, glands and sensory receptors. In other species there are also specializations of beaks, scales and feathers.
The two major tissue organizations of epithelial (ectoderm, epidermis) and mesenchyme (mesoderm connective tissue, dermis and hypodermis) are shown within skin. In addition, we have also have extensive populating by melanocytes (neural crest) and sensory nerve endings.
Possibly the first epithelial tissue specialization from which arose other epithelial specializations now located inside the body. The external skin associated structures have many different roles and functions. This system is also an excellent model for distribution or "pattern" and adult stem cells.
This lecture will be presented by a SOMS researcher Dr. Annemiek Beverdam specialising in Integumentary and Stem Cell Development. Her lecture slides are linked below.
Shown below on this page is for only background information for this topic.
Textbooks
Objectives
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Skin structure cartoon |
Online Textbooks
- Developmental Biology 6th ed. Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc.; c2000. Development of the hair follicles in fetal human skin | Image - Coordinated differentiation and morphogenesis in the mammalian tooth | Tooth Development
- Eurekah Bioscience Collection Role of GLI proteins in embryonic hair follicle development
- Molecular Biology of the Cell FGF5 is a negative regulator of hair formation
- Blue Histology Integumentary System
Terms
dermal papilla - the extensions of the dermis into the epidermis.
dermatoglyphic patterns - (Greek, derma = "skin", glyph = "carving") fingers, palms, toes, and soles skin patterns.
epidermal growth factor receptor - expressed on cells in the epidermis basal layer, signaling stimulates both epidermal growth and wound healing and also mediates an inhibition of differentiation.
rete ridge - the extensions of the epidermis into the dermis. These epidermal surface thickenings extend downward between underlying connective tissue dermal papillae. This is also the site of initial eccrine gland differentiation.
External Links
External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.
- Teeth - University of Helsinki - Gene Expression in Tooth | American Dental Association Overview - Tooth | Columbia University Medical Centre - Illustrations: How a Tooth Decays | Merck - Tooth disorders | Nemours Foundation - Teething Tots
- Neonatal Dermatology - NZ National Women's Health
- Dermatology Image Atlas - DermAtlas
<pubmed>18459147</pubmed>| Figure 1 Key steps in the development of three major ectodermal appendages
2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3 |
Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 Genetic Disorders | 10 Melanocytes | 11 Stem Cells | 12 Group |
Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision |
Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum |