File:Model for cloacal septation 01.jpg
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Model for cloacal septation
(A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.
Reference
<pubmed>22253716</pubmed>
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029372
Citation: Xu K, Wu X, Shapiro E, Huang H, Zhang L, et al. (2012) Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation. PLoS ONE 7(1): e29372. doi:10.1371/journal.pone.0029372
Copyright: © 2012 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 7. Journal.pone.0029372.g007.jpg
doi:10.1371/journal.pone.0029372.g007
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:50, 8 June 2012 | | 1,000 × 680 (73 KB) | Z8600021 (talk | contribs) | ==Model for cloacal septation== (A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activ |
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