File:Model BMP satellite cell differentiation.jpg
Model_BMP_satellite_cell_differentiation.jpg (800 × 473 pixels, file size: 75 KB, MIME type: image/jpeg)
Function of BMP signaling during satellite cell differentiation
Quiescent satellite cells (green) do not respond to BMP signals. Upon activation, satellite cells express MyoD and respond to BMP signals with phosphorylation of p-Smad (red) and reduced differentiation.
After satellite cell descendents are committed to differentiate (yellow) they express Myogenin and subsequently the BMP inhibitor Chordin.
Upon inhibition of BMP signaling, myoblasts exit the cell cycle, fuse into myotubes and undergo terminal differentiation (purple).
Postmitotic myonuclei (blue) irreversibly loose the competence to respond to BMP signals.
Figure 10
Reference
Friedrichs M, Wirsdöerfer F, Flohé SB, Schneider S, Wuelling M & Vortkamp A. (2011). BMP signaling balances proliferation and differentiation of muscle satellite cell descendants. BMC Cell Biol. , 12, 26. PMID: 21645366 DOI.
Copyright
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original file name: 1471-2121-12-26-10.jpg
Cite this page: Hill, M.A. (2024, May 11) Embryology Model BMP satellite cell differentiation.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_BMP_satellite_cell_differentiation.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 10:53, 5 February 2012 | 800 × 473 (75 KB) | S8600021 (talk | contribs) | ==Function of BMP signaling during satellite cell differentiation== Quiescent satellite cells (green) do not respond to BMP signals. Upon activation, satellite cells express MyoD and respond to BMP signals with phosphorylation of p-Smad (red) and reduced |
You cannot overwrite this file.
File usage
There are no pages that use this file.