File:Implantation cartoon 01.jpg
Original file (1,000 × 756 pixels, file size: 154 KB, MIME type: image/jpeg)
Molecular Implantation Cartoon
This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown.
Legend
- AA - arachidonic acid
- BMP2 - bone morphogenetic protein 2
- cPLA2α - cytosolic phospholipase A2α
- COUP-TFII - chicken ovalbumin upstream promoter transcription factor-2
- Cox2 - cyclooxygenase-2
- E - estrogens
- EC - epithelial cell (luminal and glandular epithelia)
- ENaC - epithelium sodium channel
- ER - estrogen receptor
- ErbB1/4
- epidermal growth factor receptor 1/4
- ERK - extracellular signal–regulated kinase
- FGF - fibroblast growth factor
- GE - glandular epithelium
- gp130 - glycoprotein 130
- Hand2 - heart- and neural crest derivatives-expressed protein 2
- HB-EGF - heparin-binding epidermal growth factor-like growth factor
- Hoxa10/11 - homeobox A10/11
- ICM - inner cell mass
- IHH - Indian hedgehog
- KLF5 - Kruppel-like factor 5
- LIF - leukemia inhibitory factor
- LIFR - LIF receptor
- LPA3 - lysophosphatidic acid receptor 3
- MSX1 - Muscle segment homeobox 1
- P4 - progesterone
- PG - prostaglandin
- PPAR-δ
- peroxisome proliferators–activating receptor δ
- PR - progesterone receptor
- Ptc - Patched
- RXR - retinoid X receptor
- SC - stromal cell
- SGK1 - serum- and glucocorticoid-inducible kinase 1
- Smo - Smoothened
- STAT3 - signal transducer and activator of transcription 3
- Tr - trophectoderm
- Wnt4/5a - Wingless-Type MMTV integration site family members 4/5a.
Compartment colours
- blue - stroma
- pink - luminal epithelium
- orange - glandular epithelium
- purple - epithelium at the attachment site.
Reference
<pubmed>23223073</pubmed>| Nat Med
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)
Nm.3012-F1.jpg
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 17:46, 18 March 2013 | 1,000 × 756 (154 KB) | Z8600021 (talk | contribs) | This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian... |
You cannot overwrite this file.
File usage
The following 4 pages use this file: