File:Implantation cartoon 01.jpg: Difference between revisions
From Embryology
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==Molecular Implantation Cartoon== | ==Molecular Implantation Cartoon== | ||
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! Compartment colours | |||
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| This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown. | |||
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* blue - stroma | |||
* pink - luminal epithelium | |||
* orange - glandular epithelium | |||
* purple - epithelium at the attachment site. | |||
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{| | {| | ||
| | ! Legend | ||
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| valign=top| | |||
* '''AA''' - arachidonic acid | * '''AA''' - arachidonic acid | ||
* '''BMP2''' - bone morphogenetic protein 2 | * '''BMP2''' - bone morphogenetic protein 2 | ||
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* '''ENaC''' - epithelium sodium channel | * '''ENaC''' - epithelium sodium channel | ||
* '''ER''' - estrogen receptor | * '''ER''' - estrogen receptor | ||
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* '''ErbB1/4''' - epidermal growth factor receptor 1/4 | * '''ErbB1/4''' - epidermal growth factor receptor 1/4 | ||
* '''ERK''' - extracellular signal–regulated kinase | * '''ERK''' - extracellular signal–regulated kinase | ||
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* '''Hoxa10/11''' - homeobox A10/11 | * '''Hoxa10/11''' - homeobox A10/11 | ||
* '''ICM''' - inner cell mass | * '''ICM''' - inner cell mass | ||
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* '''IHH''' - Indian hedgehog | * '''IHH''' - Indian hedgehog | ||
* '''KLF5''' - Kruppel-like factor 5 | * '''KLF5''' - Kruppel-like factor 5 | ||
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* '''PG''' - prostaglandin | * '''PG''' - prostaglandin | ||
* '''PPAR-δ''' - peroxisome proliferators–activating receptor δ | * '''PPAR-δ''' - peroxisome proliferators–activating receptor δ | ||
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* '''PR''' - progesterone receptor | * '''PR''' - progesterone receptor | ||
* '''Ptc''' - Patched | * '''Ptc''' - Patched | ||
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===Reference=== | ===Reference=== |
Revision as of 14:53, 17 March 2014
Molecular Implantation Cartoon
Compartment colours | |
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This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown. |
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Legend | |||
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Reference
<pubmed>23223073</pubmed>| Nat Med
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)
Nm.3012-F1.jpg
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