File:Implantation cartoon 01.jpg: Difference between revisions

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Molecular Implantation Cartoon

This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown.

Legend

AA - arachidonic acid
BMP2 - bone morphogenetic protein 2
cPLA2α - cytosolic phospholipase A2α
COUP-TFII - chicken ovalbumin upstream promoter transcription factor-2
Cox2 - cyclooxygenase-2
E - estrogens
EC - epithelial cell (luminal and glandular epithelia)
ENaC - epithelium sodium channel
ER - estrogen receptor

ErbB1/4 - epidermal growth factor receptor 1/4
ERK - extracellular signal–regulated kinase
FGF - fibroblast growth factor
GE - glandular epithelium
gp130 - glycoprotein 130
Hand2 - heart- and neural crest derivatives-expressed protein 2
HB-EGF - heparin-binding epidermal growth factor-like growth factor
Hoxa10/11 - homeobox A10/11
ICM - inner cell mass

IHH - Indian hedgehog
KLF5 - Kruppel-like factor 5
LIF - leukemia inhibitory factor
LIFR - LIF receptor
LPA3 - lysophosphatidic acid receptor 3
MSX1 - Muscle segment homeobox 1
P4 - progesterone
PG - prostaglandin
PPAR-δ - peroxisome proliferators–activating receptor δ
PR - progesterone receptor
Ptc - Patched
RXR - retinoid X receptor
SC - stromal cell
SGK1 - serum- and glucocorticoid-inducible kinase 1
Smo - Smoothened
STAT3 - signal transducer and activator of transcription 3
Tr - trophectoderm
Wnt4/5a - Wingless-Type MMTV integration site family members 4/5a.

Compartment colours

blue - stroma
pink - luminal epithelium
orange - glandular epithelium
purple - epithelium at the attachment site.

Reference

<pubmed>23223073</pubmed>| Nat Med

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)

Nm.3012-F1.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	17:46, 18 March 2013		1,000 × 756 (154 KB)	Z8600021 (talk \| contribs)	This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian...

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File usage

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@@ Line 4: / Line 4: @@
 '''Legend'''
+{|
+|
 * '''AA''' -  arachidonic acid
 * '''BMP2''' -  bone morphogenetic protein 2
@@ Line 14: / Line 15: @@
 * '''ENaC''' -  epithelium sodium channel
 * '''ER''' -  estrogen receptor
-* '''ErbB1/4
+|
-* '''epidermal growth factor receptor 1/4
+* '''ErbB1/4''' - epidermal growth factor receptor 1/4
 * '''ERK''' -  extracellular signal–regulated kinase
 * '''FGF''' -  fibroblast growth factor
@@ Line 24: / Line 25: @@
 * '''Hoxa10/11''' -  homeobox A10/11
 * '''ICM''' -  inner cell mass
+|
 * '''IHH''' -  Indian hedgehog
 * '''KLF5''' -  Kruppel-like factor 5
@@ Line 32: / Line 34: @@
 * '''P4''' -  progesterone
 * '''PG''' -  prostaglandin
-* '''PPAR-δ
+* '''PPAR-δ''' - peroxisome proliferators–activating receptor δ
-* '''peroxisome proliferators–activating receptor δ
 * '''PR''' -  progesterone receptor
 * '''Ptc''' -  Patched