File:Comparative genomic hybridization 02.jpg

Summary of Comparative Genomic Hybridization

Ideogram showing genetic imbalances detected in 71 medulloblastoma by comparative genomic hybridization (CGH). Red bars on the left of the chromosomes represent losses and green bars on the right correspond to gains of chromosomal regions in tumors; amplifications are depicted as bold green bars. Multiple cases with the same CNA are grouped as thick bars, with total number of cases displayed at the top.

"Medulloblastoma is the most common malignant brain tumor of childhood. Improvements in clinical outcome require a better understanding of the genetic alterations to identify clinically significant biological factors and to stratify patients accordingly. In the present study, we applied cytogenetic characterization to guide the identification of biologically significant genes from gene expression microarray profiles of medulloblastoma."

Original file name: Figure 2. 1471-2407-6-223-2-l.jpg http://www.biomedcentral.com/1471-2407/6/223/figure/F2

Reference

<pubmed>16968546</pubmed>| BMC Cancer

© 2006 De Bortoli et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.