File:Bone signalling pathway.gif
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Signals regulating growth plate development
Description
Signals regulating growth plate development. The growth plate is divided into four distinct zones. IHH and PTHRP coordinate chondrocyte proliferation and differentiation through a negative-feedback mechanism. Prehypertrophic and hypertrophic chondrocytes release IHH, which stimulates chondrocyte proliferation and PTHRP synthesis. PTHRP synthesized in periarticular region/resting zone before/after the second ossification center formation in turn suppresses chondrocyte differentiation associated with IHH expression. FGF9/18 from the perichondrium suppresses chondrocyte proliferation and maturation through FGFR3 in the growth plate during embryonic development and postnatal bone growth. A number of WNTs expressed by growth plate chondrocytes stimulate the proliferation of chrondrocytes (data from Long & Ornitz (2013)).
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current | 15:10, 15 October 2016 | 200 × 122 (12 KB) | Z5015544 (talk | contribs) | =Signals regulating growth plate development= =Description= Signals regulating growth plate development. The growth plate is divided into four distinct zones. IHH and PTHRP coordinate chondrocyte proliferation and differentiation through a negative-fee... |
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