File:Average Luteal Progesterone Profiles by Group.jpg: Difference between revisions

Average Luteal Progesterone Profiles by Group

Unadjusted mean luteal progesterone index values. Mean ± SEM: 22.2 ± 3.1 pg/ml (resident Bangladeshi sedentees from Sylhet [SYL], n = 39); 24.6 ± 2.5 pg/ml (adult migrants [ADU], n = 46); 38.9 ± 5.7 pg/ml (child migrants [CHI], n = 39); 40.2 ± 5.5 pg/ml (second-generation British-Bangladeshis [2ndGEN], n = 29); 45.1 ± 4.3 pg/ml (British women of European descent [WHI], n = 45).

Sample sizes include only the cycles for which an oestradiol midcycle peak and luteal progesterone rise were discernable (81%, 82%, 93%, 88%, and 94% of the original sample for SYL, ADU, CHI, 2ndGEN, and WHI groups, respectively).

Oestradiol values were obtained from data available for the same individual menstrual cycles. Ovulation dates were estimated from individual oestradiol data [22]. Confidence intervals are omitted for visual clarity. Sample sizes include all women for which hormonal data were available and may differ from total sample sizes for other aspects of data collection.

Childhood conditions influence adult progesterone levels. Núñez-de la Mora A, Chatterton RT, Choudhury OA, Napolitano DA, Bentley GR. PLoS Med. 2007 May;4(5):e167. PMID: 17503960 | PLoS Medicine

"This research demonstrates that human females use an extended period of the life cycle prior to reproductive maturation to monitor their environment and to modulate reproductive steroid levels in accordance with projected conditions they might encounter as adults. Given the prolonged investment of human pregnancy and lactation, such plasticity (extending beyond any intrauterine programming) enables a more flexible and finely tuned adjustment to the potential constraints or opportunities of the later adult environment. This research is the first, to our knowledge, to demonstrate a postuterine developmental component to variation in reproductive steroid levels in women."

Citation: Núñez-de la Mora A, Chatterton RT, Choudhury OA, Napolitano DA, Bentley GR (2007) Childhood Conditions Influence Adult Progesterone Levels. PLoS Med 4(5): e167. doi:10.1371/journal.pmed.0040167

Academic Editor: Nicholas M. Fisk, Imperial College London, United Kingdom

Received: June 29, 2006; Accepted: March 9, 2007; Published: May 15, 2007

Copyright: © 2007 Núñez-de la Mora et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.