File:Oocyte and cumulus granulosa signaling 03.jpg
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Oocyte and Cumulus Granulosa Signaling Mouse and Rat
Models for BMP15 and GDF9 homodimers and GDF9:BMP15 heterodimers in regulating cumulus granulosa cell functions. In mouse and rat, BMP15:BMP15 is inactive, whereas the GDF9:GDF9 homodimer cooperates with the GDF9:BMP15 heterodimer to regulate granulosa cell function via a SMAD2/3 pathway starting from secondary follicles. The GDF9:GDF9 homodimer is likely the dominant (active) ligand in primary follicles.
- Links: Image - human and mouse | Image - human | Image - mouse | Ovarian Follicle Molecular Interactions | BMP | Oocyte | Granulosa cell
Reference
<pubmed>23382188</pubmed>
Copyright
Proceedings National Academy of Sciences (PNAS) Liberalization of PNAS copyright policy: Noncommercial use freely allowed Note original Author should be contacted for permission to reuse for Educational purposes. See also PNAS Author Rights and Permission FAQs
- Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."
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