File:Limb induction-initiation signal 02.jpg
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Molecular Mechanisms of Limb Bud Formation
Figure from study that dshows the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.
A - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces retinoids acid (RA) locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the late real plate mesoderm (LPM).
B - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
C and D - Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).
Human TBX Family | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Human FGF Family | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Reference
Nishimoto S, Wilde SM, Wood S & Logan MP. (2015). RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation. Cell Rep , 12, 879-91. PMID: 26212321 DOI.
Copyright
Copyright © 2015 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Figure 7. resized and labeled with PMID.
Cite this page: Hill, M.A. (2024, May 23) Embryology Limb induction-initiation signal 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Limb_induction-initiation_signal_02.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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current | 13:13, 13 September 2016 | 1,280 × 1,009 (124 KB) | Z8600021 (talk | contribs) | Figure 7. The Molecular Mechanisms of Limb Bud Formation (A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LP... |
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