Abnormal Development - Fetal Alcohol Syndrome

From Embryology
Revision as of 13:45, 25 June 2015 by Z8600021 (talk | contribs)
Embryology - 28 Mar 2024    Facebook link Pinterest link Twitter link  Expand to Translate  
Google Translate - select your language from the list shown below (this will open a new external page)

العربية | català | 中文 | 中國傳統的 | français | Deutsche | עִברִית | हिंदी | bahasa Indonesia | italiano | 日本語 | 한국어 | မြန်မာ | Pilipino | Polskie | português | ਪੰਜਾਬੀ ਦੇ | Română | русский | Español | Swahili | Svensk | ไทย | Türkçe | اردو | ייִדיש | Tiếng Việt    These external translations are automated and may not be accurate. (More? About Translations)

Introduction

Fetal Alcohol Syndrome (FAS) facial features[1]

This disorder was clinically described (USA) in humans about 30 years ago (1973), while historically alcohol's teratogenic effects were identified in the early 20th century in a mix with the prohibition cause of the period.


Consuming alcohol during pregnancy is the cause of Fetal Alcohol Syndrome (FAS), consisting of a variable degree of birth defects and mental retardation, initially identified by a reduced head size and distinctive facial features.


Similar effects without the obvious alterations to appearance, but with nervous system effects, are sometimes typified as Fetal Alcohol Effects (FAE). Alcohol is able to cross the placenta from maternal circulation through the placenta into fetal circulation.


Exposure of embryos in vitro to ethanol simulates premature differentiation of prechondrogenic mesenchyme of the facial primordia.[2] This result may explain some facial abnormalities associated with FAS, the mechanism of which is still unknown.


Alcohol intake is also one of several factor known to impact upon birthweight. In Australia (2005) 6.4% of all liveborn babies were of low birthweight (less than 2,500 grams).


Cell death (apoptosis) induced by alcohol has also been suggested as relevant to craniofacial abnormalities and neurological development. The neurological effects (FAS limits IQ to around 70) may be due to cell death in the embryonic neuroepithelium (the outer layer of the developing neural tube) at an early developmental stage. Some additional evidence suggests that alcohol could also directly damage DNA.


These developmental abnormalities are maternal in origin and are not genetic, though there are probably genetic elements involved with alcoholism (More? OMIM alcoholism).


This Syndrome is 100% preventable.


Environmental Links: Introduction | low folic acid | iodine deficiency | Nutrition | Drugs | Australian Drug Categories | USA Drug Categories | thalidomide | herbal drugs | Illegal Drugs | smoking | Fetal Alcohol Syndrome | TORCH | viral infection | bacterial infection | fungal infection | zoonotic infection | toxoplasmosis | Malaria | maternal diabetes | maternal hypertension | maternal hyperthermia | Maternal Inflammation | Maternal Obesity | hypoxia | biological toxins | chemicals | heavy metals | air pollution | radiation | Prenatal Diagnosis | Neonatal Diagnosis | International Classification of Diseases | Fetal Origins Hypothesis

Some Recent Findings

  • Fetal alcohol spectrum disorders: a review of interventions for prevention and management in Indigenous communities AIHW resource sheet Feb2015
  • Prenatal Ethanol Exposure Disrupts Intraneocortical Circuitry, Cortical Gene Expression, and Behavior in a Mouse Model of FASD[3] "We document novel anatomical and gene expression abnormalities in the neocortex of newborn mice exposed to ethanol in utero. This is the first study to demonstrate large-scale changes in intraneocortical connections and disruption of normal patterns of neocortical gene expression in any prenatal ethanol exposure animal model. Neuroanatomical defects and abnormal neocortical RZRβ, Id2, and Cadherin8 expression patterns are observed in PrEE newborns, and abnormal behavior is present in 20-d-old PrEE mice. "
  • Diagnosis of fetal alcohol syndrome (FAS): German guideline version 2013[4] "Fetal alcohol syndrome (FAS) belongs to the umbrella of fetal alcohol spectrum disorders (FASD) and affects 0.02-0.8% of all annual births with a high number of undetected cases. The aim of the German guideline version 2013 is to provide objectively evaluated, evidence-based, clinically relevant and easily applicable diagnostic criteria for the full picture FAS. The following diagnostic criteria for FAS resulted: at least one deficit of growth, three defined facial characteristics and one functional or structural anomaly of the central nervous system. Confirmation of intrauterine alcohol exposure is not considered as a prerequisite for FAS diagnosis. The German guideline presented here constitutes an unbiased evidence-based approach to the diagnosis of patients with fetal alcohol syndrome. It includes a practical pocket guide FAS for a quick overview of the diagnostic workup in everyday clinical work." 2013 German Guidelines
  • Health initiatives by Indigenous people in Australia[5] "June Oscar is an Aboriginal woman from Marninwarntikura Women's Resource Centre, Fitzroy Crossing, in the Kimberley region of the Northern Territory, Australia, where about 4500 Aboriginal people live in more than 45 communities. She had attended 50 funerals in 1 year, many of which were for suicides related to alcohol abuse. She was also concerned about the one in four babies born with fetal alcohol spectrum disorder in the region, which she regarded as a particular disaster for an oral-based culture." (Includes a video)
  • Around 143,000 alcohol and other drug treatment episodes were provided in Australia in 2008-09[6] "More episodes of this treatment were for alcohol than any other drug type, and this proportion has now risen four years in a row. ...As seen in previous years, most treatment episodes (66%) were provided to male clients."
  • Proceedings of the 2008 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group.[7]
More recent papers
Mark Hill.jpg
PubMed logo.gif

This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.

  • This search now requires a manual link as the original PubMed extension has been disabled.
  • The displayed list of references do not reflect any editorial selection of material based on content or relevance.
  • References also appear on this list based upon the date of the actual page viewing.


References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

More? References | Discussion Page | Journal Searches | 2019 References | 2020 References

Search term: Fetal Alcohol Syndrome

<pubmed limit=5>Fetal Alcohol Syndrome</pubmed>

Fetal Alcohol Spectrum Disorders

"Fetal Alcohol Spectrum Disorders (FASD) is an umbrella term describing the range of effects that can occur in an individual whose mother drank alcohol during pregnancy. These effects may include physical, mental, behavioral, and/or learning disabilities with possible lifelong implications. The term FASD is not intended for use as a clinical diagnosis." [8]

Fetal Alcohol Effect (FAE), Alcohol-related Birth Defect (ARBD), and Alcohol-Related Neurodevelopmental Disorder (ARND) are terms also used to describe a the spectrum of conditions related to prenatal alcohol exposure.

About Alcohol

Ethanol structure
Ethanol structure 3D-balls

The pure chemical, alcohol is generally available in alcoholic beverages at between 0.5 - 40% concentration. Metabolic rates for alcohol differ between men and women and is also dependent on body size. (SDS datasheet for alcohol)

The neurological euphoria induced by alcohol has been associated with the rapid release of dopamine in limbic areas of the brain.

Not all FAS babies are from alcoholics, but they do represent a significant population more at risk. The genetics of alcoholism are multifactorial, with several candidate genes identified as associated with the disease. (More? OMIM - Alcoholism)

Alcohol Statistics

Statistical information is often difficult to isolate directly, as alcohol is often combined with other drugs (tobacco, illicit drugs, etc).

There is an interesting "American paradox" that Americans have a relatively low rate of per capita alcohol consumption, yet the USA has the highest incidence of FAS (20 times all other countries) in the world.

USA studies by the CDC have reported FAS prevalence rates from 0.2 to 1.5 cases per 1,000 births across various populations. Disadvantaged groups, Native Americans and Australians, and other minorities have been documented to have rates as high as three to five FAS affected children per 1,000 children.[8]

Other studies reflecting a variety of ascertainment methodologies have produced estimates ranging from 0.5 to 2.0 cases per 1,000 live births. Using the CDC FAS estimates, among the approximately 4 million infants born each year, an estimated 1,000 to 6,000 will be born with FAS. Studies of particularly vulnerable populations yield prevalence estimates that far exceed those of other common disabilities.

Binge Drinking

Tracking binge drinking among U.S. childbearing-age women.[9] "The estimated binge drinking prevalence among childbearing-age women 18-44 years (USA) for the years 2001, 2002, and 2003 was 11.9%, 12.4%, and 13.0%, respectively. The estimated number of childbearing-age women who engaged in binge drinking rose from 6.2 million in 2001 to 7.1 million in 2003, an increase of 0.9 million."

FAS Diagnosis

There are a range of postnatal features which are used diagnostically including facial appearance and digit effects.

In addition, there are under development a number of different techniques which may be useful in the future for prenatal diagnosis.

Pregnancy characteristics of women giving birth to children with fetal alcohol syndrome in Far North Queensland.[10] "There is the potential to identify prospectively women presenting for antenatal care who are heavy drinkers and risk FAS in their infants, using the self-reported information about alcohol intake already being collected by our service; such women may then be offered specific interventions to try to reduce alcohol consumption in pregnancy."

Facial Appearance of FAS

Some, or all, of the following facial features are associated with FAS. There has also been a recent study to develop an automated facial analysis technique.[11]

FASface.jpg FAS facial features[1]
  • Microcephaly - leads to small head circumference
  • Palpebral fissure - short opening of eye
  • Epicanthal folds - fold of skin at inside of corner of eye
  • Midface - flat
  • Ears - curve at top part of outer ear is underdeveloped and folded over parallel to curve beneath. Gives the appearance of a "railroad track"
  • Nasal Bridge - low
  • Philtrum - Indistinct, vertical grooves between nose and mouth
  • Upper Lip - thin
  • Micrognathia - small jaw

FAS Digital Effects

In addition to the distinct facial effects, there may also be abnormalities associated with the digits, fingers or toes.

  • Camptodactyly - permanent flexion contracture of a finger or toe.
  • Clinodactyly - permanent curving of the fifth finger (usually toward the other fingers) also seen for other fingers or toes.
  • Palmar crease - transverse flexion crease of the palm close to the fingers, described as "Hockey stick", widens like the end of a hockey stick and ends between the second and third fingers.


Guidelines

2013 German Guidelines

Diagnosis of fetal alcohol syndrome (FAS): German guideline version 2013[4] "Fetal alcohol syndrome (FAS) belongs to the umbrella of fetal alcohol spectrum disorders (FASD) and affects 0.02-0.8% of all annual births with a high number of undetected cases. The aim of the German guideline version 2013 is to provide objectively evaluated, evidence-based, clinically relevant and easily applicable diagnostic criteria for the full picture FAS. The following diagnostic criteria for FAS resulted: at least one deficit of growth, three defined facial characteristics and one functional or structural anomaly of the central nervous system. Confirmation of intrauterine alcohol exposure is not considered as a prerequisite for FAS diagnosis. The German guideline presented here constitutes an unbiased evidence-based approach to the diagnosis of patients with fetal alcohol syndrome. It includes a practical pocket guide FAS for a quick overview of the diagnostic workup in everyday clinical work."

There were 6 key recommendations.

2009 Australia Draft Guidelines

26 August 2008 Draft Australian alcohol guidelines for low-risk drinking[12] "Following the initial consideration by the NHMRC Council, NHRMC is finalising the NHMRC Australian alcohol guidelines for low risk drinking, including the latest research. The Council is expected to consider them again in late 2008."

  • Pregnancy characteristics of women giving birth to children with fetal alcohol syndrome in Far North Queensland. [13] "There is the potential to identify prospectively women presenting for antenatal care who are heavy drinkers and risk FAS in their infants, using the self-reported information about alcohol intake already being collected by our service; such women may then be offered specific interventions to try to reduce alcohol consumption in pregnancy."

Links: Draft Australian alcohol guidelines for low-risk drinking | National Alcohol Strategy Publications | National Alcohol Strategy 2001 to 2003-04 Occasional Paper

2005 USA Guidelines

2005 USA Guidelines Fetal Alcohol Syndrome Prevention Team, Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities[14]


FAS USA guideline sm.jpg

Publication by national task force (USA)[15]

2005 Canadian Guidelines

Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis[16] "The guidelines are based on widespread consultation of expert practitioners and partners in the field. The guidelines have been organized into 7 categories: screening and referral; the physical examination and differential diagnosis; the neurobehavioural assessment; and treatment and follow-up; maternal alcohol history in pregnancy; diagnostic criteria for fetal alcohol syndrome (FAS), partial FAS and alcohol-related neurodevelopmental disorder; and harmonization of Institute of Medicine and 4-Digit Diagnostic Code approaches. The diagnosis requires a comprehensive history and physical and neurobehavioural assessments; a multidisciplinary approach is necessary."

Finland

Fetal alcohol spectrum disorders in Finland: clinical delineation of 77 older children and adolescents.[17] "We have recently completed dysmorphology examination and parent/guardian interviews of the 77 children in the Finnish cohort. ...Although 11% were born prematurely, 70% demonstrated prenatal growth deficiency, and 45% were microcephalic. Other than growth deficits and the cardinal facial features, the most common major and minor anomalies noted were: camptodactyly (55%), "hockey stick" or other altered palmar creases (51%), refractive errors (40%), strabismus (38%), dental crowding (43%), nail hypoplasia (38%), GU anomalies (22%), and congenital heart defects (18%), "Railroad track" ears were not observed in this population."

Brain Development

Mouse Face Phenotypes following Ethanol Exposure
Mouse Face Phenotypes following Ethanol Exposure[18]


New brain imaging techniques have allowed greater insight into the effects of alcohol on the brain. In FAS children this includes qualitative and quantitative studies of the postnatal brain including changes include anatomical displacements (corpus callosum) and changes in the neural layer (gray matter) density of the brain.

Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure.[19] "Significant cortical thickness excesses of up to 1.2 mm were observed in the FASD subjects in large areas of bilateral temporal, bilateral inferior parietal, and right frontal regions."

Teratogenic effects of alcohol: a decade of brain imaging.[20] "Results indicated displacements in the corpus callosum, increased gray matter densities in both hemispheres in the perisylvian regions, and altered gray matter asymmetry in portions of the temporal lobes in the brains of alcohol-exposed subjects."

Sensory Development

Prenatal alcohol exposure delays the development of the cortical barrel field in neonatal rats.[21] "...our model system to examine the effect of prenatal alcohol exposure (PAE) on early somatosensory cortical development. ....These findings suggest that PAE delays the development of the somatosensory cortex (SI); such delays may interfere with timing and formation of cortical circuits."

Bone Development

Binge alcohol exposure during all three trimesters alters bone strength and growth in fetal sheep.[22] "Maternal bones were not different among groups. The higher alcohol dose resulted in reduced fetal femoral bone strength, whereas the tibial bone strength was lower when compared with the normal control subjects. In contrast, the lower alcohol dose increased fetal femoral strength compared to the normal control subjects. The alcohol-exposed fetal bones also tended to exhibit reduced lengths."

Mouse Model

Mouse maternal ethanol skull effects.png
Variable midfacial dysmorphism and microcephaly in a/a offspring of mothers that consumed ethanol during gestation.[23]

References

  1. 1.0 1.1 <pubmed>16050451</pubmed>
  2. <pubmed>10235393</pubmed>
  3. <pubmed>24285895</pubmed>
  4. 4.0 4.1 <pubmed>23618613</pubmed>
  5. <pubmed>21684368</pubmed>| Lancet
  6. Australian Institute of Health and Welfare 2008. Alcohol and other drug treatment services in Australia 2006–07: report on the National Minimum Data Set. Drug treatment series no. 8. Cat. no. HSE 59. Canberra: AIHW.
  7. <pubmed>19560631</pubmed>
  8. 8.0 8.1 Bertrand J, Floyd RL, Weber MK, O'Connor M, Riley EP, Johnson KA, Cohen DE, National Task Force on FAS/FAE. Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis. Atlanta, GA: Centers for Disease Control and Prevention; 2004. PDF
  9. <pubmed>17150249</pubmed>
  10. <pubmed>18532953</pubmed>
  11. <pubmed>18713153</pubmed>
  12. NHMRC Website alcohol guidelines
  13. <pubmed>18532953</pubmed>
  14. <pubmed>16251866</pubmed>
  15. FAS Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis." Atlanta, GA: Centers for Disease Control and Prevention; 2004. Bertrand J, Floyd RL, Weber MK, O'Connor M, Riley EP, Johnson KA, Cohen DE, National Task Force on FAS/FAE.
  16. <pubmed>15738468</pubmed>
  17. <pubmed>16353236</pubmed>
  18. <pubmed>22937012</pubmed>
  19. <pubmed>17443018</pubmed>
  20. <pubmed>15095470</pubmed>
  21. <pubmed>16506013</pubmed>
  22. <pubmed>16905445</pubmed>
  23. <pubmed>20084100</pubmed> | PLoS

Reviews

Reviews Fetal Alcohol Syndrome

<pubmed>15956765</pubmed> <pubmed>15609253</pubmed> <pubmed>15956766</pubmed> <pubmed>15898848</pubmed> <pubmed>15629980</pubmed> <pubmed>14717994</pubmed> <pubmed>12685673</pubmed> <pubmed>11810953</pubmed>

Bertrand J, Floyd RL, Weber MK, O'Connor M, Riley EP, Johnson KA, Cohen DE. National Task Force on FAS/FAE. Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis. Atlanta, GA: Centers for Disease Control and Prevention; 2004.

Reviews Alcohol Tissue Damage

<pubmed>15939092</pubmed> <pubmed>14602814</pubmed> <pubmed>9192055</pubmed> <pubmed>8974357</pubmed>

Reviews Fatty Acid Ethyl Esters

<pubmed>15183290</pubmed> <pubmed>14984244</pubmed> <pubmed>12951847</pubmed> <pubmed>12456329</pubmed> <pubmed>12450674</pubmed> <pubmed>12442912</pubmed> <pubmed>12324241</pubmed> <pubmed>11805717</pubmed> <pubmed>11762132</pubmed> <pubmed>11586934</pubmed> <pubmed>10471114</pubmed> <pubmed>9925383</pubmed> <pubmed>10209651</pubmed> <pubmed>8974332</pubmed> <pubmed>8452205</pubmed>

Articles

<pubmed>20451895</pubmed>(More? Folic Acid and Neural Tube Defects) <pubmed>19302087</pubmed>| Alcoholism: Clinical and Experimental Research <pubmed>20528824</pubmed> (More? Molecular Development - Epigenetics) <pubmed>18713153</pubmed> <pubmed>18532953</pubmed> <pubmed>18162064</pubmed> <pubmed>17516899</pubmed> <pubmed>16166387</pubmed> <pubmed>16157106</pubmed> <pubmed>15629980</pubmed>

Search Pubmed

June 2010 "fetal alcohol syndrome" All (3475) Review (611) Free Full Text (396) "fetal alcohol spectrum disorders" All (306) Review (65) Free Full Text (84)

Search Pubmed: fetal alcohol syndrome | fetal alcohol effects | fetal alcohol spectrum disorders


Search OMIM: Alcoholism

Results - Alcohol Dependence

Books on Fetal Alcohol Syndrome

A selection of recent general public information books on FAS and children with FAS, available from various internet commercial suppliers (search using the book title). Please note that this listing does not reflect an endorsement of the book or its content and is provided for educational purposes only.

  • The Challenge of Fetal Alcohol Syndrome, by Ann Streissguth (editor) and Jonathan Kanter (editor)
  • Recognizing and Managing Children With Fetal Alcohol Syndrome-Fetal Alcohol Effects, by Brenda McCreight
  • Fetal Alcohol Syndrome, Fetal Alcohol Effects: Strategies for Professionals, by Diane Malbin
  • Fetal Alcohol Syndrome: A Guide for Families and Communities, by Ann Pytkowicz Streissguth
  • The Best I Can Be: Living with Fetal Alcohol Syndrome-Effects, by Liz Kulp and Jodee Kulp
  • The Broken Cord, by Michael Dorris
  • Our FAScinating Journey: Keys to Brain Potential Along the Path of Prental Brain Injury, by Jodee Kulp
  • Fantastic Antone Grows Up: Adolescents and Adults With Fetal Alcohol Syndrome, by Judith Kleinfeld (editor), Barbara Morse (editor) and Siobhan Wescott (editor)

Internet supplier link: Amazon

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.


Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link



Cite this page: Hill, M.A. (2024, March 28) Embryology Abnormal Development - Fetal Alcohol Syndrome. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Fetal_Alcohol_Syndrome

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G