Abnormal Development - Ectopic Implantation

Embryology - 27 Mar 2015 Facebook linkTwitter linkPinterest link Translate

Arabic | Chinese (simplified) | French | German | Hebrew | Hindi | Indonesian | Japanese | Korean | Portuguese | Romanian | Russian | Spanish These external translations are automated and may not be accurate.

Tubal pregnancy historic.jpg


Tubal Pregnancy

Human development during week 2 is about implantation and the endocrine signaling to block the normal menstrual cycle. The blastocyst implantation process should normally and does occur within the body of the uterus. There are a number of additional abnormal sites of implantation that are outside the uterine body, these are described as ectopic implantation or ectopic pregnancy (Greek, ektopos = "out of place").

The most common form of human ectopic pregnancy is when implantation occurs within the uterine tube, described as a tubal pregnancy. Note that the endocrine signals blocking the menstrual cycle and indicating a pregnancy will still be released following this ectopic implantation. Ectopic pregnancies are therefore often identified by early ultrasound scans.

Ectopic pregnancy is also a high-risk maternal medical condition with an approximate incidence of 1.5 to 2 % in reported pregnancies. There is some indication that the incidence may be increasing (United States has increased from 4.5 per 1,000 pregnancies in 1970 to an estimated 19.7 per 1,000 pregnancies in 1992[1])

The risk factors for tubal ectopic pregnancy include: tubal damage by infection (particularly Chlamydia trachomatis) or surgery, smoking and in vitro fertilization therapy. Prolonged tubal damage is often described as pelvic inflammatory disease and "scarring" can affect the cilia-mediated transport of the blastocyst during the first week of development.

This is also the most common cause of pregnancy-related deaths in the first trimester. A recent United Kingdom enquiry into maternal deaths[2], identified ectopic pregnancy as the fourth most common cause of maternal death (73% of early pregnancy deaths).

Ectopic sites are named according to the anatomical location: Tubal (Ampullary, Isthmic, Cornual), Cervical and Ovarian. A study of 1800 surgically treated ectopics between 1992 and 2001 identified implantation sites by frequency: interstitial (2.4%), isthmic (12.0%), ampullary (70.0%), fimbrial (11.1%), ovarian (3.2%) or abdominal (1.3%).[3]

International Classification of Diseases: Chapter XV Pregnancy Childbirth - O00 Ectopic pregnancy | O01 Hydatidiform mole

Links: Implantation | Week 2 | Placenta - Abnormalities | Ultrasound - Ectopic Pregnancy | Ultrasound | Ectopic Implantation Research | Historic 1920 Paper

Some Recent Findings

Abnormal implantation sites
  • Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy (EP)[4] "For treatment of EP, double-dose methotrexate had efficacy and safety comparable to that of single-dose methotrexate; it had better success among patients with moderately high β-hCG and led to a shorter follow up."
  • Misdiagnosis of cervical ectopic pregnancy (CEP)[5] "Misdiagnosis of CEP upon initial presentation is a common occurrence. Transvaginal ultrasound performed by a qualified practitioner may increase detection and prevent treatment delay."
  • Human tubal ectopic pregnancy and knockout mouse models.[6] "Tubal abnormalities and dysfunction, such as altered contractility or abnormal ciliary activity, have been speculated to lead to tubal ectopic pregnancy. To elucidate the cellular and molecular mechanisms of the tubal transport process, several knockout (KO) mouse models have been developed. This review summarizes what has been learned from studies of the Fallopian tube in caspase-1, cannabinoid receptor and Dicer1 KO mice."
More recent papers
Mark Hill.jpg
This table shows an automated computer PubMed search using the listed sub-heading term.
  • Therefore the list of references do not reflect any editorial selection of material based on content or relevance.
  • References appear in this list based upon the date of the actual page viewing.

References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.

Links: References | Discussion Page | Pubmed Most Recent

Search term: Ectopic Pregnancy

Panayotis Xiromeritis, Chrysoula Margioula-Siarkou, Dimosthenis Miliaras, Ioannis Kalogiannidis Laparoscopic excision of coexisting left tubal and right pseudotubal pregnancy after conservative management of previous ectopic pregnancy with methotrexate: an unusual clinical entity. Case Rep Surg: 2015, 2015;645826 PMID: 25810942 Sunil Kumar Samal, Setu Rathod Cervical ectopic pregnancy. J Nat Sci Biol Med: 2015, 6(1);257-60 PMID: 25810679 M Belen Rabaglino, Emiel D Post Uiterweer, Arun Jeyabalan, W Allen Hogge, Kirk P Conrad [78-OR]: A systems biology approach reveals evidence for defective endometrial maturation in women destined to develop preeclampsia (PE). Pregnancy Hypertens: 2015, 5(1);41-2 PMID: 25787428 Nirmala Gurung, Greta Grosse, Markus Draaken, Alina C Hilger, Nuzhat Nauman, Andreas Müller, Ulrich Gembruch, Waltraut M Merz, Heiko Reutter, Michael Ludwig Mutations in PTF1A are not a common cause for human VATER/VACTERL association or neural tube defects mirroring Danforth's short tail mouse. Mol Med Rep: 2015; PMID: 25775927 Onur Erol, Dinç Süren, Mehmet Karaca, Cem Sezer Ultrasonography for the prediction of extension of trophoblastic infiltration into the tubal wall in ampullary pregnancy. Ginekol. Pol.: 2015, 86(1);16-20 PMID: 25775870

Ultrasound Ectopic Implantation

Tubal Ectopic Bicornuate Uterus Ectopic
Ectopic 01.jpg
 ‎‎Ectopic Pregnancy
Page | Play
Bicornuate uterus ectopic movie icon.jpg
 ‎‎Bicornuate Ectopic
Page | Play
Ectopic 01.jpg Ectopic 01 zoom.jpg
Ectopic 01 limbs.jpg Ectopic 01 heart.jpg

Links: Ectopic Implantation | Ultrasound

Computed Tomography Ectopic Implantation

Computed Tomography imaging findings of a 37-year-old woman with interstitial pregnancy.[7] Showing initial CT detection and a subsequent scan following rupture causing a hematoma around uterus and a massive hemoperitoneum.

Ectopic pregnancy CT 01.jpg

Initial CT - gestational sac

Ectopic pregnancy CT 02.jpg

Follow-up CT - massive hemoperitoneum

Ectopic pregnancy CT 03.jpg

CT - hematoma around uterus

Links: Computed Tomography

Magnetic Resonance Imaging Abdominal Ectopic Implantation

2W SPAIR sagittal MRI of lower abdomen demonstrating the placental invasion.[8]
  • Placenta was attached tightly to the mesentery of sigmoid colon and was loosely adhered to the left abdominal sidewall.
  • The fetus was localized at the right of the abdomen and was related to the placenta by a cord.
Abdominal ectopic pregnancy MRI.jpg

See also Heterotopic Pregnancy


Ectopic Pregnancies- United-States 1970-1992.jpg

Ectopic Pregnancies- United-States 1970-1992[9]

Ectopic Pregnancies- United-States 1997-2006.jpg

Ectopic Pregnancy Histology

Tubal pregnancy 01.jpg

CDC Image by Dr. Edwin P. Ewing, Jr., 1972

Stage7 bf5b.jpg

Ed Uthman Image (pathologist in Houston, Texas) section of ectopic (tubal) pregnancy about Carnegie stage 7 in Week 3.

Image version links: ExtraLarge 1712x1206px | Large 1024x721px | Medium 500x352px

Stage15 bf2b.jpg

Ed Uthman Image (pathologist in Houston, Texas) image of of ectopic (tubal) pregnancy about Carnegie stage 15 in Week 5.

Image version links: ExtraLarge 1874 x 2000px | Large 959 x 1024px | Medium 468 x 500px

Tubal Ectopic Pregnancy

Chlamydia infections (Chlamydia trachomatis) are the most common bacterial sexually transmitted infection, often undiagnosed and asymptomatic. The infections can ascend the female genital tract, colonizing the endometrial mucosa, then the uterine tubes. This type of infection is described as pelvic inflammatory disease (PID).
Tubal pregnancy shown after hysterectomy

Interstitial Pregnancy

(cornual pregnancy) A less common type 2 to 4% of ectopic pregnancies. The gestation develops in the uterine portion of the fallopian tube lateral to the round ligament.
Interstitial ectopic pregnancy[10]

Ovarian Ectopic Pregnancy

Clinical operative photograph at the beginning of the procedure of the laparoscopic treatment of the ovarian pregnancy.


  • u - normal aspect of the uterus.
  • t - left fallopian tube.
  • e - ruptured ectopic pregnancy in the left ovary.
Ovarian ectopic pregnancy 01.jpg

Ovarian Ectopic Pregnancy[11]

Cervical Ectopic Pregnancy

Cervical Ectopic Pregnancy Ultrasound[12]

This form of ectopic pregnancy is a rare high-risk condition and represents less than 1% of all ectopic pregnancies. The reported incidence varies between 1:1,000 to 1:18,000.

Rudimentary Horn Pregnancy

A rare types of ectopic pregnancy (about 1 in 76,000 pregnancies) in most cases the horn is non-communicating. Therefore fertilisation probably occurs by transperitoneal migration. This form untreated can also lead to uterine rupture.

Caesarean Scar Pregnancy

A rare types of ectopic pregnancy (about 1 in 2000 pregnancies), but probably increasing as caesarean rates rise. The gestation is completely surrounded by both myometrium and fibrous tissue of the caesarean section scar and separated from the endometrial cavity and endocervical canal.

Heterotopic Pregnancy

Heterotopic pregnancy MRI[13]

(Greek, heteros = other) Clinical term for a very rare pregnancy of two or more embryos, consisting of both a uterine cavity embryo implantation and an ectopic implantation. The ectopic implantation usually identified by prenatal scanning as occurring within the uterine tube (tubal pregnancy) though has also been identified as abdominal pregnancies.[13][14]

Ectopic Molar Pregnancy

Ectopic molar pregnancy 01.jpg

Left-sided unruptured ampullary ectopic pregnancy at laparoscopy.[15]

Links: Hydatidiform Mole

Ruptured Ectopic

Ruptured ectopic pregnancy 01.jpg

Ruptured ectopic pregnancy[16]


(MTX, amethopterin) Drug with several different uses including the treatment of ectopic pregnancy[17] and for the induction of medical abortions. Acts as a antimetabolite and antifolate (folic acid antagonist) drug that inhibits DNA synthesis in actively dividing cells, including trophoblasts, and therefore has other medical uses include cancer and autoimmune disease treatment. Treatment success in ectopic pregnancy relates to serum β human chorionic gonadotropin (β-hCG) concentration.

Links: Medline Plus

International Classification of Diseases

The International Classification of Diseases (ICD) World Health Organization's classification used worldwide as the standard diagnostic tool for epidemiology, health management and clinical purposes.

The two main codes cover O00 Ectopic pregnancy and O01 Hydatidiform mole.

Note that there is an additional code covering complications of the clinical treatment O08 Complications following abortion and ectopic and molar pregnancy This code is provided primarily for morbidity coding. For use of this category reference should be made to the morbidity coding rules and guidelines in Volume 2.

Links: O00 Ectopic pregnancy | O01 Hydatidiform mole | Chapter XV Pregnancy Childbirth | International Classification of Diseases


  1. Centers for Disease Control and Prevention (CDC) Ectopic pregnancy--United States, 1990-1992. MMWR Morb. Mortal. Wkly. Rep.: 1995, 44(3);46-8 PMID: 7823895
  2. Confidential Enquiry into Maternal Deaths (CEMD) Why Mothers Die 2000–2002 PDFPDF2
  3. J Bouyer, J Coste, H Fernandez, J L Pouly, N Job-Spira Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum. Reprod.: 2002, 17(12);3224-30 PMID: 12456628
  4. Hossam O Hamed, Salah R Ahmed, Abdullah A Alghasham Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy. Int J Gynaecol Obstet: 2012, 116(1);67-71 PMID: 22035883
  5. Valerie I Shavell, Mazen E Abdallah, Mark A Zakaria, Jay M Berman, Michael P Diamond, Elizabeth E Puscheck Misdiagnosis of cervical ectopic pregnancy. Arch. Gynecol. Obstet.: 2012, 285(2);423-6 PMID: 21748311
  6. Ruijin Shao Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models. Hum. Reprod.: 2010, 25(3);584-7 PMID: 20023297
  7. Byung Seok Shin, Mi-Hyun Park Incidental detection of interstitial pregnancy on CT imaging. Korean J Radiol: 2009, 11(1);123-5 PMID: 20046504 | PMC2799642 | Korean J Radiol.
  8. Recep Yildizhan, Ali Kolusari, Fulya Adali, Ertan Adali, Mertihan Kurdoglu, Cagdas Ozgokce, Numan Cim Primary abdominal ectopic pregnancy: a case report. Cases J: 2009, 2;8485 PMID: 19918376 | Cases J.
  9. Centers for Disease Control and Prevention (CDC) Ectopic pregnancy--United States, 1990-1992. MMWR Morb. Mortal. Wkly. Rep.: 1995, 44(3);46-8 PMID: 7823895
  10. M Sami Walid, Richard L Heaton Diagnosis and laparoscopic treatment of cornual ectopic pregnancy. Ger Med Sci: 2010, 8; PMID: 20725587 | German Medical Science
  11. Serena Resta, Eliana Fuggetta, Federica D'Itri, Simona Evangelista, Adele Ticino, Maria Grazia Porpora Rupture of Ovarian Pregnancy in a Woman with Low Beta-hCG Levels. Case Rep Obstet Gynecol: 2012, 2012;213169 PMID: 23198195 | Case Rep Obstet Gynecol.
  12. Mohammad R Mohebbi, Kurt A Rosenkrans, Eric E Luebbert, Tauhni T Hunt, Michael J Jung Ectopic pregnancy in the cervix: a case report. Case Rep Med: 2011, 2011;858241 PMID: 22110520 | PMC3205779
  13. 13.0 13.1 Sue Yazaki Sun, Edward Araujo Júnior, Julio Elito Júnior, Liliam Cristine Rolo, Felipe Favorette Campanharo, Stéphanno Gomes Pereira Sarmento, Luciano Marcondes Machado Nardozza, Antonio Fernandes Moron Diagnosis of heterotopic pregnancy using ultrasound and magnetic resonance imaging in the first trimester of pregnancy: a case report. Case Rep Radiol: 2012, 2012;317592 PMID: 23259128 | Case Rep Radiol.
  14. Gabriela Gayer Images in clinical medicine. Abdominal ectopic pregnancy. N. Engl. J. Med.: 2012, 367(24);2334 PMID: 23234516 | N Engl J Med.
  15. Najoua Bousfiha, Sanaa Erarhay, Adnane Louba, Hanan Saadi, Chahrazad Bouchikhi, Abdelaziz Banani, Hind El Fatemi, Med Sekkal, Afaf Laamarti Ectopic molar pregnancy: a case report. Pan Afr Med J: 2012, 11;63 PMID: 22655097
  16. Bahareh Samiei-Sarir, Christopher Diehm Recurrent ectopic pregnancy in the tubal remnant after salpingectomy. Case Rep Obstet Gynecol: 2013, 2013;753269 PMID: 24151570 | PMC3789312 | Case Rep Obstet Gynecol.
  17. T G Stovall, F W Ling Single-dose methotrexate: an expanded clinical trial. Am. J. Obstet. Gynecol.: 1993, 168(6 Pt 1);1759-62; discussion 1762-5 PMID: 8317518


J L V Shaw, S K Dey, H O D Critchley, A W Horne Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum. Reprod. Update: 2010, 16(4);432-44 PMID: 20071358

Ruijin Shao Understanding the mechanisms of human tubal ectopic pregnancies: new evidence from knockout mouse models. Hum. Reprod.: 2010, 25(3);584-7 PMID: 20023297

Juan Manuel Corpa Ectopic pregnancy in animals and humans. Reproduction: 2006, 131(4);631-40 PMID: 16595714


N Exalto, G P Vooys, J W Meyer, W P Lange Ovarian pregnancy: a morphologic description. Eur. J. Obstet. Gynecol. Reprod. Biol.: 1980, 11(3);179-87 PMID: 7194809

C E Purslow Tubal Pregnancy showing Foetus undergoing Dissolution. Proc. R. Soc. Med.: 1915, 8(Obstet Gynaecol Sect);68 PMID: 19978839

E Matsunaga, K Shiota Ectopic pregnancy and myoma uteri: teratogenic effects and maternal characteristics. Teratology: 1980, 21(1);61-9 PMID: 7385056

Search Pubmed

June 2010

  • "ectopic pregnancy" All (14958) Review (1350) Free Full Text (1196)
  • "tubal pregnancy" All (8010) Review (683) Free Full Text (630)

Search Pubmed: ectopic pregnancy | ectopic implantation | tubal pregnancy | tubal implantation

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name.

Glossary Links

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols

Cite this page: Hill, M.A. (2015) Embryology Abnormal Development - Ectopic Implantation. Retrieved March 27, 2015, from https://embryology.med.unsw.edu.au/embryology/index.php/Abnormal_Development_-_Ectopic_Implantation

What Links Here?
© Dr Mark Hill 2015, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
Last modified on 27 December 2014, at 08:25