File:Thalidomide - limb signaling.jpg
Thalidomide_-_limb_signaling.jpg (628 × 540 pixels, file size: 88 KB, MIME type: image/jpeg)
Changes in limb signaling events occur secondary to vascular inhibition[1]
CPS49 - a tetrafluorinated analogue of thalidomide that is chemically and structurally related to thalidomide breakdown products.
(A–P) HH St18 embryos treated with DMSO or CPS49 and fixed 3 h, 6 h, or 24 h later and stained for cell death (A–F) or by wholemount in situ hybridization for Fgf8 (G–I), Fgf10 (J–L), Bmp4 (M and N), or HIF-1 (O and P) expression; untreated limb to left (G–P). (E and F) Arrows indicate increased cell death in CPS49-treated limbs. (H and I) Arrowheads indicate decreased Fgf8 expression relative to the contralateral limb, which serves as an internal control.
There is no significant difference in numbers of proliferating cells in CPS49-treated limbs as compared with control limbs. (Scale bars: A–F, 500 μm; G–I, 400 μm; Q–S, 250 μm.)
Modified from Fig. 2. A-L http://www.pnas.org/content/106/21/8573/F2.expansion.html
- ↑ <pubmed>19433787</pubmed>
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current | 16:34, 17 June 2010 | 628 × 540 (88 KB) | S8600021 (talk | contribs) | ==Changes in limb signaling events occur secondary to vascular inhibition<ref><pubmed>19433787</pubmed></ref>== CPS49 - a tetrafluorinated analogue of thalidomide that is chemically and structurally related to thalidomide breakdown products. (A–P) HH |
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