Talk:Embryology History - Robert Winston

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On this website the Discussion Tab or "talk pages" for a topic has been used for several purposes: References - recent and historic that relates to the topic Additional topic information - currently prepared in draft format Links - to related webpages Topic page - an edit history as used on other Wiki sites Lecture/Practical - student feedback Student Projects - online project discussions. Links: Pubmed Most Recent \| Reference Tutorial \| Journal Searches Contents 1 Glossary Links 2 2011 2.1 Cryptic splice sites and split genes 3 Introduction 4 Glossary Links Glossary Links Glossary: A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \| Numbers \| Symbols \| Term Link Cite this page: Hill, M.A. (2024, June 2) Embryology Embryology History - Robert Winston. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Embryology_History_-_Robert_Winston

2011

Cryptic splice sites and split genes

Nucleic Acids Res. 2011 Aug;39(14):5837-44. Epub 2011 Apr 5.

Kapustin Y, Chan E, Sarkar R, Wong F, Vorechovsky I, Winston RM, Tatusova T, Dibb NJ.

Source National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA. yurikapustin@gmail.com

Abstract

We describe a new program called cryptic splice finder (CSF) that can reliably identify cryptic splice sites (css), so providing a useful tool to help investigate splicing mutations in genetic disease. We report that many css are not entirely dormant and are often already active at low levels in normal genes prior to their enhancement in genetic disease. We also report a fascinating correlation between the positions of css and introns, whereby css within the exons of one species frequently match the exact position of introns in equivalent genes from another species. These results strongly indicate that many introns were inserted into css during evolution and they also imply that the splicing information that lies outside some introns can be independently recognized by the splicing machinery and was in place prior to intron insertion. This indicates that non-intronic splicing information had a key role in shaping the split structure of eukaryote genes.

PMID 21470962

Introduction

Below are text and image excerpts from a historic paper on "The Anatomy of a 17.8mm Human Embryo" by Thyng, FW published originally in The American Journal of Anatomy, Vol.17, No.1 These drawings are based on studies of the Harvard Embryological Collection while he was in Minot's Lab in 1907-08.

He was also an anatomist at Northwestern University Medical School.

The embryo external appearance and dimensions suggest that it is a Carnegie stage 19 embryo (Week 7, 48 - 51 days, 16 - 18 mm).

Reference: Thyng F.W., (1914) The anatomy of a 17.8mm human embryo. American Journal of Anatomy 14, 31-113

History Links: Embryology History

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Cite this page: Hill, M.A. (2024, June 2) Embryology Embryology History - Robert Winston. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Embryology_History_-_Robert_Winston

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