File:Implantation cartoon 01.jpg: Difference between revisions
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* '''PG''' - prostaglandin | * '''PG''' - prostaglandin | ||
* '''PPAR-δ''' - peroxisome proliferators–activating receptor δ | * '''PPAR-δ''' - peroxisome proliferators–activating receptor δ | ||
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* '''PR''' - progesterone receptor | * '''PR''' - progesterone receptor | ||
* '''Ptc''' - Patched | * '''Ptc''' - Patched | ||
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* '''Tr''' - trophectoderm | * '''Tr''' - trophectoderm | ||
* '''Wnt4/5a''' - Wingless-Type MMTV integration site family members 4/5a. | * '''Wnt4/5a''' - Wingless-Type MMTV integration site family members 4/5a. | ||
|} | |||
'''Compartment colours''' | '''Compartment colours''' |
Revision as of 14:45, 17 March 2014
Molecular Implantation Cartoon
This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown.
Legend
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Compartment colours
- blue - stroma
- pink - luminal epithelium
- orange - glandular epithelium
- purple - epithelium at the attachment site.
Reference
<pubmed>23223073</pubmed>| Nat Med
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)
Nm.3012-F1.jpg
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