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(==Mouse Cerebellar Foliation Defects== (A–B) Midsagittal sections of newborn (P0) wild-type and Mdm2puro/Δ7-9 cerebella stained with H&E. The four principal fissures, denoted by asterisks, are apparent in wild-type cerebella at P0 (A), whereas only tw)
 
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===Reference===
===Reference===
<pubmed>21437245</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017884 PLoS One.]
<pubmed>21437245</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017884 PLoS One.]
[[Category:Mouse]] [[Category:Neural]] [[Category:Abnormal Development]]

Latest revision as of 23:56, 22 September 2011

Mouse Cerebellar Foliation Defects

(A–B) Midsagittal sections of newborn (P0) wild-type and Mdm2puro/Δ7-9 cerebella stained with H&E. The four principal fissures, denoted by asterisks, are apparent in wild-type cerebella at P0 (A), whereas only two are evident in Mdm2puro/Δ7-9 mice (B). Wild-type pups show two additional fissures, indicated by arrows, whereas mutant pups do not. (C–D) Superimposition of P0 (purple outline), P7 (blue outline), and adult (green outline) cerebella from wild-type (C) or Mdm2puro/Δ7-9 (D) mice. By P7, all four primary fissures, as well as two additional fissures, are evident in Mdm2puro/Δ7-9 mice. Moreover, even in adulthood, the mutant cerebellum does not reach the size or complexity of the wild-type cerebellum. Abbreviations are: prc, precentral; pc, pre-culminate; pr, primary; pp, prepyramidal; sec, secondary; pl, posterolateral fissures.


Figure 3. Journal.pone.0017884.g003.jpg

Reference

<pubmed>21437245</pubmed>| PLoS One.

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current23:55, 22 September 2011Thumbnail for version as of 23:55, 22 September 2011574 × 600 (115 KB)S8600021 (talk | contribs)==Mouse Cerebellar Foliation Defects== (A–B) Midsagittal sections of newborn (P0) wild-type and Mdm2puro/Δ7-9 cerebella stained with H&E. The four principal fissures, denoted by asterisks, are apparent in wild-type cerebella at P0 (A), whereas only tw

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