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Diagramatic representation of the steroidogenic pathways in human pre-luteinized follicles (A) and post luteinized follicles (B), demonstrating granulosa dependence on theca cell testosterone steroidogenesis in pre-luteinized follicles and the de novo synthesis of progesterone from cholesterol due to induction/up-regulation of CYP11A and 3βHSD after the gonadotropin surge in post luteinized follicles. | Diagramatic representation of the steroidogenic pathways in human pre-luteinized follicles (A) and post luteinized follicles (B), demonstrating granulosa dependence on theca cell testosterone steroidogenesis in pre-luteinized follicles and the de novo synthesis of progesterone from cholesterol due to induction/up-regulation of CYP11A and 3βHSD after the gonadotropin surge in post luteinized follicles. | ||
The principle steroid product of luteinized pre-ovulatory granulosa is progesterone, a differentiation triggered by the gonadotropin surge. However, absolute steroid levels are associated with follicular size, not oocyte maturation/ability to fertilize. | |||
Original file name: Figure 5. 1477-7827-8-117-5-l.jpg | Original file name: Figure 5. 1477-7827-8-117-5-l.jpg |
Revision as of 15:37, 17 May 2011
Ovarian follicular steroid synthesis
Diagramatic representation of the steroidogenic pathways in human pre-luteinized follicles (A) and post luteinized follicles (B), demonstrating granulosa dependence on theca cell testosterone steroidogenesis in pre-luteinized follicles and the de novo synthesis of progesterone from cholesterol due to induction/up-regulation of CYP11A and 3βHSD after the gonadotropin surge in post luteinized follicles.
The principle steroid product of luteinized pre-ovulatory granulosa is progesterone, a differentiation triggered by the gonadotropin surge. However, absolute steroid levels are associated with follicular size, not oocyte maturation/ability to fertilize.
Original file name: Figure 5. 1477-7827-8-117-5-l.jpg Wen et al. Reproductive Biology and Endocrinology 2010 8:117 doi:10.1186/1477-7827-8-117
Reference
<pubmed>20937107</pubmed>| Reprod Biol Endocrinol.
© 2010 Wen et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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