Developmental Signals - Notch: Difference between revisions
From Embryology
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* '''Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development'''<ref><pubmed>19161597</pubmed></ref> "Notch-dependent processes apparently differ with respect to their requirement for levels of POFUT1. Normal Lfng expression and anterior-posterior somite patterning is highly sensitive to reduced POFUT1 levels in early mammalian embryos, whereas other early Notch-dependent processes such as establishment of left-right asymmetry or neurogenesis are not. Thus, it appears that in the presomitic mesoderm (PSM) Notch signalling is particularly sensitive to POFUT1 levels. Reduced POFUT1 levels might affect Notch trafficking or overall O-fucosylation. Alternatively, reduced O-fucosylation might preferentially affect sites that are substrates for LFNG and thus important for somite formation and patterning." | * '''Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development'''<ref><pubmed>19161597</pubmed></ref> "Notch-dependent processes apparently differ with respect to their requirement for levels of POFUT1. Normal Lfng expression and anterior-posterior somite patterning is highly sensitive to reduced POFUT1 levels in early mammalian embryos, whereas other early Notch-dependent processes such as establishment of left-right asymmetry or neurogenesis are not. Thus, it appears that in the presomitic mesoderm (PSM) Notch signalling is particularly sensitive to POFUT1 levels. Reduced POFUT1 levels might affect Notch trafficking or overall O-fucosylation. Alternatively, reduced O-fucosylation might preferentially affect sites that are substrates for LFNG and thus important for somite formation and patterning." | ||
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==Notch Receptors== | |||
===NOTCH1=== | |||
===NOTCH2=== | |||
===NOTCH3=== | |||
===NOTCH4=== | |||
==Notch Ligands== | |||
* JAG1 | |||
* JAG2 | |||
* DLL1 | |||
* DLL3 | |||
* DLL4 | |||
==Functions== | ==Functions== | ||
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===Cartilage Development=== | ===Cartilage Development=== | ||
==References== | ==References== |
Revision as of 10:50, 14 November 2010
Introduction
The notch proteins were first identified in drosophila development and have since been identified as regulators of cell fate decisions during development. These are a family of cell surface proteins that act as single-pass transmembrane receptors.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
|
Notch Receptors
NOTCH1
NOTCH2
NOTCH3
NOTCH4
Notch Ligands
- JAG1
- JAG2
- DLL1
- DLL3
- DLL4
Functions
Developmental patterning signal.
Mesoderm Development
Cartilage Development
References
Search Bookshelf Notch
Search Pubmed
Search Pubmed Now: Notch Signaling
External Links
Glossary Links
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Cite this page: Hill, M.A. (2024, June 1) Embryology Developmental Signals - Notch. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Notch
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G