File:Spleen structure 01.jpg: Difference between revisions
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==Spleen Structure== | ==Spleen Structure and Cell Distribution== | ||
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Schematic representation of the organization of the spleen (left panel). | | valign="top"|Schematic representation of the organization of the spleen (left panel). | ||
* The white pulp consists of T cell (lymphocyte) zones (also known as the periarteriolar lymphoid sheath (PALS)) containing networks of fibroblastic reticular cells (FRC) surrounding a central arteriole, together with B cell follicles containing a central network of follicular dendritic cells (FDC). | * The white pulp consists of T cell (lymphocyte) zones (also known as the periarteriolar lymphoid sheath (PALS)) containing networks of fibroblastic reticular cells (FRC) surrounding a central arteriole, together with B cell follicles containing a central network of follicular dendritic cells (FDC). | ||
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* Large numbers of macrophages phagocytose dying or damaged red blood cells in the red pulp (not shown). | * Large numbers of macrophages phagocytose dying or damaged red blood cells in the red pulp (not shown). | ||
* Immune cells enter the white pulp at regions where the T cell zones abut the MZ, known as the MZ bridging channels. | * Immune cells enter the white pulp at regions where the T cell zones abut the MZ, known as the MZ bridging channels. | ||
| valign="top"|An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel). | |||
An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel). | |||
* The distribution of cells: | * The distribution of cells: | ||
** '''T cells''' - (white) CD3+ | ** '''T cells''' - (white) CD3+ | ||
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** '''dendritic cells''' - (green) (DCs) CD11c+ | ** '''dendritic cells''' - (green) (DCs) CD11c+ | ||
** '''stromal cells''' - (red) ER-TR7+ | ** '''stromal cells''' - (red) ER-TR7+ | ||
* The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel). | * The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel). | ||
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Scale bars represent 130 μM. | Scale bars represent 130 μM. | ||
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===Reference=== | ===Reference=== | ||
{{#pmid:19644499}} | |||
====Copyright==== | |||
[http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller] | [http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller] | ||
[[File_talk:Spleen_structure_01.jpg|Permissions]] | [[File_talk:Spleen_structure_01.jpg|Permissions]] | ||
{{Footer}} | |||
[[Category:Spleen]] | [[Category:Spleen]] |
Latest revision as of 10:03, 19 July 2019
Spleen Structure and Cell Distribution
Schematic representation of the organization of the spleen (left panel).
|
An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel).
Scale bars represent 130 μM. |
Reference
Mueller SN & Germain RN. (2009). Stromal cell contributions to the homeostasis and functionality of the immune system. Nat. Rev. Immunol. , 9, 618-29. PMID: 19644499 DOI.
Copyright
Cite this page: Hill, M.A. (2024, May 23) Embryology Spleen structure 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Spleen_structure_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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