File:Spleen structure 01.jpg: Difference between revisions
From Embryology
No edit summary |
m (→Reference) |
||
(9 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
==Spleen Structure== | ==Spleen Structure and Cell Distribution== | ||
{| | |||
| valign="top"|Schematic representation of the organization of the spleen (left panel). | |||
* The white pulp consists of T cell (lymphocyte) zones (also known as the periarteriolar lymphoid sheath (PALS)) containing networks of fibroblastic reticular cells (FRC) surrounding a central arteriole, together with B cell follicles containing a central network of follicular dendritic cells (FDC). | |||
* Marginal zones (MZ) surrounding the white pulp contain marginal reticular cells (MRC), particularly at the edges of the B cell follicles. | |||
* Blood and leukocytes entering the spleen pass through branches of the central arteriole, which end in the marginal sinuses and red pulp. | |||
* In the cords of the red pulp, a dense network of reticular fibroblasts and fibres construct an open blood network, which is marked by its lack of a typical endothelial cell lining. | |||
* Large numbers of macrophages phagocytose dying or damaged red blood cells in the red pulp (not shown). | |||
* Immune cells enter the white pulp at regions where the T cell zones abut the MZ, known as the MZ bridging channels. | |||
| valign="top"|An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel). | |||
* The distribution of cells: | |||
** '''T cells''' - (white) CD3+ | |||
** '''B cells''' - (blue) B220+ | |||
** '''macrophages''' - (cyan) CD169+ MZ | |||
** '''dendritic cells''' - (green) (DCs) CD11c+ | |||
** '''stromal cells''' - (red) ER-TR7+ | |||
* The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel). | |||
* Networks of stromal cells and reticular fibres form in the white pulp, including the fibroblastic reticular cells (FRCs) in T cell zones, follicular dendritic cells (FDCs) in B cell follicles (ER-TR7−) and marginal reticular cells (MRCs) in the MZ. | |||
* A dense network of stromal cells and reticular fibres is present in the red pulp. | |||
Scale bars represent 130 μM. | |||
|} | |||
{{Spleen Histology}} | |||
===Reference=== | |||
{{#pmid:19644499}} | |||
====Copyright==== | |||
[http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller] | |||
[[File_talk:Spleen_structure_01.jpg|Permissions]] | |||
{{Footer}} | |||
[[Category:Spleen]] |
Latest revision as of 10:03, 19 July 2019
Spleen Structure and Cell Distribution
Schematic representation of the organization of the spleen (left panel).
|
An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel).
Scale bars represent 130 μM. |
Reference
Mueller SN & Germain RN. (2009). Stromal cell contributions to the homeostasis and functionality of the immune system. Nat. Rev. Immunol. , 9, 618-29. PMID: 19644499 DOI.
Copyright
Cite this page: Hill, M.A. (2024, May 23) Embryology Spleen structure 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Spleen_structure_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 18:55, 22 February 2012 | 1,200 × 463 (211 KB) | Z8600021 (talk | contribs) |
You cannot overwrite this file.
File usage
The following page uses this file: