Ductus Deferens Development: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[File:Historic-testis.jpg|thumb|200px|Historic testis drawing]] | [[File:Historic-testis.jpg|thumb|200px|Historic testis drawing]] | ||
''Draft Page - notice removed when completed.'' | |||
The male internal genital tract leaving each of the male testis is the {{ductus deferens}} (vas deferens; Latin "carrying-away vessel"; plural: vasa deferentia). | The male internal genital tract leaving each of the male testis is the {{ductus deferens}} (vas deferens; Latin "carrying-away vessel"; plural: vasa deferentia). | ||
The excretory duct of the testis that is the continuation of the canal of the epididymis. Develops from the {{mesonephric duct}}. Anatomically beginning at the lower part of the tail of the epididymis it is at first very tortuous, but gradually becoming less twisted it ascends along the posterior border of the testis and medial side of the epididymis, and, as a constituent of the spermatic cord, traverses the inguinal canal to the abdominal inguinal ring. | The excretory duct of the testis that is the continuation of the canal of the epididymis. Develops from the paired '''{{mesonephric duct}}s''' ([[History_-_Embryologists#Caspar_Friedrich_Wolff_.281733_-_1794.29|Wolffian ducts]]). | ||
Anatomically beginning at the lower part of the tail of the epididymis it is at first very tortuous, but gradually becoming less twisted it ascends along the posterior border of the testis and medial side of the epididymis, and, as a constituent of the spermatic cord, traverses the inguinal canal to the abdominal inguinal ring. | |||
There are also separate pages describing: {{ChrY}} Chromosome | {{spermatozoa}} | {{testis}} | {{epididymis}} | {{ductus deferens}} | {{prostate}} | {{penis}} | [[:Category:Male|Category:Male]] | |||
<br> | |||
{{Male Vignette}} | |||
<br> | <br> | ||
{{Genital Links}} | {{Genital Links}} | ||
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|-bgcolor="F5FAFF" | |-bgcolor="F5FAFF" | ||
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* '''[https://www.omim.org/entry/182307 SLC9A3] Affects Vas Deferens Development and Associates with Taiwanese Congenital Bilateral Absence of the Vas Deferens'''{{#pmid:30956978|PMID30956978}} "The pathophysiology of Taiwanese congenital bilateral absence of the vas deferens (CBAVD) is different from that in Caucasians. In particular, major cystic fibrosis transmembrane conductance regulator (CFTR) mutations and cystic fibrosis are absent in the former. DISCUSSION: Our findings build upon previous data associated with CBAVD pathogenesis. Here, we now report for the first time an association between CBAVD and loss of SLC9A3 and propose that specific defects in the reproductive duct due to SLC9A3 variants drive CBAVD development. CONCLUSION: The data implicate loss of SLC9A3 as a basis of Taiwanese CBAVD and highlight SLC9A3 function in reproduction." [https://www.omim.org/entry/182307 OMIM - SLC9A3] | |||
* '''Reciprocal Spatiotemporally Controlled {{Apoptosis}} Regulates Wolffian Duct Cloaca Fusion'''{{#pmid:29326158|PMID29326158}} "The epithelial Wolffian duct (WD) inserts into the cloaca (primitive bladder) before metanephric kidney development, thereby establishing the initial plumbing for eventual joining of the ureters and bladder. Defects in this process cause common anomalies in the spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). However, developmental, cellular, and molecular mechanisms of WD-cloaca fusion are poorly understood. Through systematic analysis of early WD tip development in mice, we discovered that a novel process of spatiotemporally regulated apoptosis in WD and cloaca was necessary for WD-cloaca fusion. Aberrant RET tyrosine kinase signaling through tyrosine (Y) 1062, to which PI3K- or ERK-activating proteins dock, or Y1015, to which PLCγ docks, has been shown to cause CAKUT-like defects. Cloacal apoptosis did not occur in RetY1062F mutants, in which WDs did not reach the cloaca, or in RetY1015F mutants, in which WD tips reached the cloaca but did not fuse. Moreover, inhibition of ERK or apoptosis prevented WD-cloaca fusion in cultures, and WD-specific genetic deletion of YAP attenuated cloacal apoptosis and WD-cloacal fusion in vivo Thus, cloacal apoptosis requires direct contact and signals from the WD tip and is necessary for WD-cloacal fusion. These findings may explain the mechanisms of many CAKUT." {{Apoptosis}} | |||
|} | |} | ||
{| class="wikitable mw-collapsible mw-collapsed" | {| class="wikitable mw-collapsible mw-collapsed" | ||
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| {{Older papers}} | | {{Older papers}} | ||
|} | |} | ||
==Ductus Deferens Histology== | |||
{| | |||
|+ '''Ductus Deferens''' (Vas deferens) {{HE}} | |||
|- | |||
! Overview | |||
! Epithelium | |||
|- | |||
| [[File:Ductus deferens 01.jpg|400px]] | |||
| [[File:Ductus deferens 02.jpg|400px]] | |||
|- | |||
| | |||
* mucosa forms low longitudinal folds. | |||
* lined by a pseudostratified columnar epithelium. | |||
* cells have long stereocilia. | |||
* lamina propria is unusually rich in elastic fibres. | |||
* muscularis is well developed (up to 1.5 mm thick) | |||
** thick circular layer of smooth muscle between thinner inner and outer longitudinal layers. | |||
** structure palpable in the spermatic cord. | |||
* ductus surrounded by an adventitia. | |||
| | |||
* mucosa forms low longitudinal folds. | |||
* lined by a pseudostratified columnar epithelium. | |||
* cells have long stereocilia. | |||
* lamina propria is unusually rich in elastic fibres. | |||
|} | |||
<gallery> | |||
File:Testis histology 016.jpg | |||
File:Testis histology 017.jpg | |||
</gallery> | |||
==Abnormalities== | ==Abnormalities== | ||
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{{ICD-11 Testis anomalies table}} | {{ICD-11 Testis anomalies table}} | ||
==Additional Images== | |||
<gallery> | |||
File:Nelsen1953 fig002.jpg|male reproductive system | |||
File:Keith1902 fig099.jpg|male bladder and urethra at birth | |||
File:Lowsley1912 fig02.jpg|Human Fetus 7.5 cm CRL | |||
File:Kollmann450.jpg|Ductus deferens, prostate and seminal vesicles | |||
File:Gray1152.jpg|Ductus deferens, prostate and seminal vesicles | |||
</gallery> | |||
===Historic=== | |||
{{Historic Disclaimer}} | |||
{{Ref-Watson1918}} | |||
<gallery> | |||
File:Watson1918 fig01.jpg|fig 1 | |||
File:Watson1918 fig02.jpg|fig 2 | |||
File:Watson1918 fig03.jpg|fig 3 | |||
File:Watson1918 fig04.jpg|fig 4 | |||
File:Watson1918 fig05.jpg|fig 5 | |||
File:Watson1918 fig06.jpg|fig 6 | |||
File:Watson1918 fig07.jpg|fig 7 | |||
File:Watson1918 fig08.jpg|fig 8 | |||
File:Watson1918 fig09.jpg|fig 9 | |||
File:Watson1918 plate01.jpg|plate 1 | |||
File:Watson1918 plate02.jpg|plate 2 | |||
File:Watson1918 plate03.jpg|plate 3 | |||
</gallery> | |||
==References== | ==References== |
Latest revision as of 08:32, 19 June 2019
Embryology - 5 Jun 2024 Expand to Translate |
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Introduction
Draft Page - notice removed when completed.
The male internal genital tract leaving each of the male testis is the ductus deferens (vas deferens; Latin "carrying-away vessel"; plural: vasa deferentia).
The excretory duct of the testis that is the continuation of the canal of the epididymis. Develops from the paired mesonephric ducts (Wolffian ducts).
Anatomically beginning at the lower part of the tail of the epididymis it is at first very tortuous, but gradually becoming less twisted it ascends along the posterior border of the testis and medial side of the epididymis, and, as a constituent of the spermatic cord, traverses the inguinal canal to the abdominal inguinal ring.
There are also separate pages describing: Y Chromosome | spermatozoa | testis | epididymis | ductus deferens | prostate | penis | Category:Male
Historic Embryology |
Caspar Friedrich Wolff (1734-1794) was a German embryologist and anatomist best known today for identifying the Wolffian duct (mesonephric duct; ductus deferens, epididymis), Wolffian body (mesonephros) and Wolffian cyst (mesonephric origin uterine broad ligament cyst) that bear his name. Thought also to be a founder of the germ layer theory. His doctorate dissertation Theoria generationis (1774) discarded the developmental theory of preformation. Later in his career, his teaching in Berlin was opposed by the professors of the Medical-Surgical College, who had guild privileges to teach medicine. |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Ductus Deferens Embryology | Ductus Deferens Development | Vas Deferens Development |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page. |
Ductus Deferens Histology
Overview | Epithelium |
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Abnormalities
Male Infertility Genes
Gene abbreviation | Name | Gene Location | Online Mendelian Inheritance in Man (OMIM) |
HUGO Gene Nomenclature Committee (HGNC) |
GeneCards (GCID) | Diagnosis |
---|---|---|---|---|---|---|
AURKC | Aurora kinase C | 19q13.43 | 603495 | 11391 | GC19P057230 | Macrozoospermia |
CATSPER1 | Cation channel sperm-associated 1 | 11q13.1 | 606389 | 17116 | GC11M066034 | Asthenozoospermia |
CFTR | Cystic fibrosis transmembrane conductance regulator | 7q31.2 | 602421 | 1884 | GC07P117465 | Obstructive azoospermia |
DNAH1 | Dynein axonemal heavy chain 1 | 3p21.1 | 603332 | 2940 | GC03P052350 | Asthenozoospermia |
DPY19L2 | Dpy-19-like 2 gene | 12q14.2 | 613893 | 19414 | GC12M063558 | Globozoospermia |
GALNTL5 | Polypeptide N-acetylgalactosaminyltransferase-like 5 | 7q36.1 | 615133 | 21725 | GC07P151956 | Asthenozoospermia |
MAGEB4 | MAGE family member B4 | Xp21.2 | 300153 | 6811 | GC0XP030260 | Azoospermia |
NANOS1 | Nanos C2HC-type zinc finger 1 | 10q26.11 | 608226 | 23044 | GC10P119029 | Azoospermia |
NR0B1 | Nuclear receptor subfamily 0 group B member 1 | Xp21.2 | 300473 | 7960 | GC0XM030322 | Azoospermia |
NR5A1 | Nuclear receptor subfamily 5 group A member 1 | 9q33.3 | 184757 | 7983 | GC09M124481 | Azoospermia |
SOHLH1 | Spermatogenesis and oogenesis-specific basic helix–loop–helix 1 | 9q34.3 | 610224 | 27845 | C09M135693 | Azoospermia |
vSPATA16 | Spermatogenesis-associated 16 | 3q26.31 | 609856 | 29935 | GC03M172889 | Globozoospermia |
SYCE1 | Synaptonemal complex central element protein 1 | 10q26.3 | 611486 | 28852 | GC10M133553 | Azoospermia |
TAF4B | TATA-box binding protein-associated factor 4b | 18q11.2 | 601689 | 11538 | GC18P026225 | Azoospermia |
TEX11 | Testis expressed 11 | Xq13.1 | 300311 | 11733 | GC0XM070528 | Azoospermia |
TEX15 | Testis expressed 15, meiosis and synapsis associated | 8p12 | 605795 | 11738 | GC08M030808 | Azoospermia |
WT1 | Wilms tumour 1 | 8p12 | 607102 | 12796 | GC11M032365 | Azoospermia |
ZMYND15 | Zinc-finger MYND-type containing 15 | 17p13.2 | 614312 | 20997 | GC17P004740 | Azoospermia |
Table data source[3] (table 1) Links: fertilization | spermatozoa | testis | Male Infertility Genes | Female Infertility Genes | oocyte | ovary | Genetic Abnormalities | ART Asthenozoospermia - (asthenospermia) term for reduced spermatozoa motility. Azoospermia - term for no spermatozoa located in the ejaculate. Globozoospermia - term for spermatozoa with a round head and no acrosome. |
International Classification of Diseases
ICD-11 5A81 Testicular dysfunction or testosterone-related disorders |
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|
genital abnormalities | ICD-11 |
Additional Images
Historic
Historic Disclaimer - information about historic embryology pages |
---|
Pages where the terms "Historic" (textbooks, papers, people, recommendations) appear on this site, and sections within pages where this disclaimer appears, indicate that the content and scientific understanding are specific to the time of publication. This means that while some scientific descriptions are still accurate, the terminology and interpretation of the developmental mechanisms reflect the understanding at the time of original publication and those of the preceding periods, these terms, interpretations and recommendations may not reflect our current scientific understanding. (More? Embryology History | Historic Embryology Papers) |
Watson EM. The development of the seminal vesicles in man. (1918) Amer. J Anat. 24(4): 395 - 439.
References
- ↑ Wu YN, Chen KC, Wu CC, Lin YH & Chiang HS. (2019). SLC9A3 Affects Vas Deferens Development and Associates with Taiwanese Congenital Bilateral Absence of the Vas Deferens. Biomed Res Int , 2019, 3562719. PMID: 30956978 DOI.
- ↑ Hoshi M, Reginensi A, Joens MS, Fitzpatrick JAJ, McNeill H & Jain S. (2018). Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion. J. Am. Soc. Nephrol. , 29, 775-783. PMID: 29326158 DOI.
- ↑ Harper JC, Aittomäki K, Borry P, Cornel MC, de Wert G, Dondorp W, Geraedts J, Gianaroli L, Ketterson K, Liebaers I, Lundin K, Mertes H, Morris M, Pennings G, Sermon K, Spits C, Soini S, van Montfoort APA, Veiga A, Vermeesch JR, Viville S & Macek M. (2018). Recent developments in genetics and medically assisted reproduction: from research to clinical applications. Eur. J. Hum. Genet. , 26, 12-33. PMID: 29199274 DOI.
Reviews
de Mello Santos T & Hinton BT. (2019). We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect. Andrology , , . PMID: 31033257 DOI.
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Cite this page: Hill, M.A. (2024, June 5) Embryology Ductus Deferens Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Ductus_Deferens_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G