File:Hair follicle development.jpg: Difference between revisions

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Organization of the epidermis.

Hair follicles contain stem cells located in the bulge (b, green), with the potential to generate lower hair follicle (lf), sebaceous gland (sg, orange) upper follicle (uf) and interfollicular epidermis (IFE, beige). The schematic shows the organization of keratinocytes in the IFE, as proposed by the stem/TA cell hypothesis. The basal layer comprises stem cells (S, blue), transit amplifying cells (TA, dark green), and post-mitotic basal cells (red), which migrate out of the basal layer as they differentiate (arrows).

Projected Z-stack confocal images of IFE wholemounts from AhcreERT R26EYFP/wt mice viewed from the basal surface at the times shown following induction. Yellow, EYFP; blue, DAPI nuclear stain. Scale bar, 20 microns.

Original file name: Nature05574-f1.2.jpg

Reference

MRC - Phil Jones Laboratory

Reprinted by permission from Macmillan Publishers Ltd: Nature. 2007 Mar 8;446(7132):185-9, copyright (2007)

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	00:37, 22 April 2010		800 × 663 (191 KB)	S8600021 (talk \| contribs)	Organization of the epidermis. Hair follicles contain stem cells located in the bulge (b, green), with the potential to generate lower hair follicle (lf), sebaceous gland (sg, orange) upper follicle (uf) and interfollicular epidermis (IFE, beige). The s

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 Original file name: Nature05574-f1.2.jpg
+==Reference==
-A single type of progenitor cell maintains normal epidermis. Clayton E, Doupe DP, Klein AM, Winton DJ, Simons BD, Jones PH. Nature. 2007 Mar 8;446(7132):185-9. [http://www.ncbi.nlm.nih.gov/pubmed/17330052 PMID: 17330052]
+<pubmed>17330052</pubmed>
 [http://www.hutchison-mrc.cam.ac.uk/Jones.html MRC - Phil Jones Laboratory]