File:Corneal epithelial cells 01.jpg: Difference between revisions

Latest revision as of 11:56, 30 August 2014

Corneal Epithelial Cells cartoon

The ocular surface is composed of three epithelia - conjunctival, limbal and corneal.

Limbal stem cells are located in the palisades of Vogt, the transitional zone between the cornea and the conjunctiva.
Limbal stem cells are close to blood vessels.
They generate transient amplifying cells that terminally differentiate after a discrete number of cell divisions to corneal epithelial cells and undergo both centripetal migration and vertical migration.

Reference

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Dovepress Open Access - Articles published under this arrangement are made freely available online upon publication without subscription barriers to access. Users of such published articles are entitled to use, reproduce, disseminate, or display these articles provided that: The original authorship is properly and fully attributed; The journal and publisher are attributed as the original place of publication with correct citation details given; If an original work is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this is clearly indicated; No articles are reproduced for commercial use without the prior consent of DMP and payment to DMP of any appropriate fee. Rights of Authors, Readers and the Publisher

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	11:40, 30 August 2014		800 × 540 (49 KB)	Z8600021 (talk \| contribs)	Corneal Epithelial Cells cartoon== The ocular surface is composed of three epithela, conjunctival, limbal and corneal. Limbal stem cells are located in the palisades of Vogt, the transitional zone between the cornea and the conjunctiva. Limbal stem ce...

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Vision - Cornea Development

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-Corneal Epithelial Cells cartoon==
+==Corneal Epithelial Cells cartoon==
-The ocular surface is composed of three epithela, conjunctival, limbal and corneal. Limbal stem cells are located in the palisades of Vogt, the transitional zone between the cornea and the conjunctiva. Limbal stem cells are close to blood vessels. They generate transient amplifying cells that terminally differentiate after a discrete number of cell divisions to corneal epithelial cells and undergo both centripetal migration and vertical migration.
+The ocular surface is composed of three epithelia - conjunctival, limbal and corneal.
-Clin Ophthalmol. 2007 Dec;1(4):373-82.
+* Limbal stem cells are located in the palisades of Vogt, the transitional zone between the cornea and the conjunctiva.
-Recent advances in corneal regeneration and possible application of embryonic stem cell-derived corneal epithelial cells.
+* Limbal stem cells are close to blood vessels.
-Kayama M1, Kurokawa MS, Ueno H, Suzuki N.
+* They generate transient amplifying cells that terminally differentiate after a discrete number of cell divisions to corneal epithelial cells and undergo both centripetal migration and vertical migration.
-Author information
-Abstract
-The depletion of limbal stem cells due to various diseases leads to corneal opacification and visual loss. The unequivocal identification and isolation of limbal stem cells may be a considerable advantage because long-term, functional recovery of corneal epithelium is linked to graft constructs that retain viable stem cell populations. As specific markers of limbal stem cells, the ATP-binding cassette, sub-family G, member2 (ABCG2), a member of the multiple drug-resistance (MDR) family of membrane transporters which leads to a side population phenotype, and transcription factor p63 were proposed recently. Conventional corneal transplantation is not applicable for patients with limbal stem cells deficiency, because the conventional allograft lacks limbal stem cells. The introduction of limbal epithelial cell transplantation was a major advance in the therapeutic techniques for reconstruction of the corneal surface. Limbal epithelial cell transplantation is clinically conducted when cultured allografts as well as autografts are available; however, allografts have a risk of immunologic rejection and autografts are hardly available for patients with bilateral ocular surface disorders. Embryonic stem (ES) cells are characterized by their capacity to proliferate indefinitely and to differentiate into any cell type. We induced corneal epithelial cells from ES cells by culturing them on type IV collagen or alternatively, by introduction of the pax6 gene into ES cells. Recent advances in our study supports the possibility of their clinical use as a cell source for reconstruction of the damaged corneal surface. This review summarizes the recent advances in corneal regeneration therapies and the possible application of ES cell-derived corneal epithelial cells.
-KEYWORDS:
-corneal epithelial cell; embryonic stem cell; limbal stem cell; transplantation
-PMID 19668514
+:Links: [[Vision_-_Cornea_Development|Cornea Development]]
+===Reference===
+<pubmed>19668514</pubmed>
 ====Copyright====
-{{Dove Open Access}}
+{{Dovepress Open Access}}
-Articles published under this arrangement are made freely available online upon publication without subscription barriers to access. Users of such published articles are entitled to use, reproduce, disseminate, or display these articles provided that:
-The original authorship is properly and fully attributed;
-The journal and publisher are attributed as the original place of publication with correct citation details given;
+[[Category:Cornea]][[Category:Vision]][[Category:Cartoon]]
-If an original work is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this is clearly indicated;
-No articles are reproduced for commercial use without the prior consent of DMP and payment to DMP of any appropriate fee.
-http://www.dovepress.com/author_guidelines.php?content_id=696
-http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704521/figure/f1-co-1-373/