Genital - Female Development
|Embryology - 18 Apr 2015 Translate|
Arabic | Chinese (simplified) | French | German | Hebrew | Hindi | Indonesian | Japanese | Korean | Portuguese | Romanian | Russian | Spanish These external translations are automated and may not be accurate.
The male and female reproductive systems develop initially "indifferently", it is the product of the Y chromosome SRY gene that initially makes the "difference". The paramesonephric (Müllerian Duct) contribute the majority of female internal genital tract, while the mesonephric duct degenerates.
The mesonephric/paramesonephric duct changes are one of the first male/female differences that occur in development, while external genitaila remain indeterminate in appearance for quite a while.
There are many different issues to consider in the development of the genital system. Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities.
- Genital Links: Introduction | Lecture - Medicine | Lecture - Science | Online Practical | Primordial Germ Cell | Meiosis | Female | Ovary | Oocyte | Uterus | Vagina | Reproductive Cycles | Menstrual Cycle | Male | Testis | Spermatozoa | Prostate | Genital Movies | Abnormalities | Assisted Reproductive Technology | Puberty | Category:Genital
|Historic Embryology - Genital|
|1902 The Uro-Genital System | 1912 Urinogenital Organ Development | 1921 Urogenital Development | 1921 External Genital Development | Historic Disclaimer|
Some Recent Findings
|More recent papers|
References listed on the rest of the content page and the associated discussion page (listed under the publication year sub-headings) do include some editorial selection based upon both relevance and availability.
Z Cui, M Hui, Y Liu, C Song, X Li, Y Li, L Liu, G Shi, S Wang, F Li, X Zhang, C Liu, J Xiang, K H Chu High-density linkage mapping aided by transcriptomics documents ZW sex determination system in the Chinese mitten crab Eriocheir sinensis. Heredity (Edinb): 2015; PMID: 25873149 Tao Yu, Qing Qing, Na Deng, Xiao-Hui Min, Li-Na Zhao, Jie-Yao Li, Zhong-Sheng Xia, Qi-Kui Chen CXCR4 positive cell-derived Pdx1-high/Shh-low cells originated from embryonic stem cells improve the repair of pancreatic injury in mice. Cell Biol. Int.: 2015; PMID: 25820869 Tatsuo Kido, Yun-Fai Chris Lau Roles of the Y chromosome genes in human cancers. Asian J. Androl.: 2015; PMID: 25814157 Jin Cai, Weiwei Guan, Xiaorong Tan, Caiyu Chen, Liangpeng Li, Na Wang, Xue Zou, Faying Zhou, Jialiang Wang, Fang Pei, Xinjian Chen, Hao Luo, Xinquan Wang, Duofen He, Lin Zhou, Pedro A Jose, Chunyu Zeng SRY Gene Transferred by Extracellular Vesicles Accelerates Atherosclerosis by Promotion of Leukocyte Adherence to Endothelial Cells. Clin. Sci.: 2015; PMID: 25783200 Zheyong Huang, Chenguang Li, Shan Yang, Jianfeng Xu, Yunli Shen, Xinxing Xie, Yuxiang Dai, Hao Lu, Hui Gong, Aijun Sun, Juying Qian, Junbo Ge Magnetic resonance hypointensive signal primarily originates from extracellular iron particles in the long-term tracking of mesenchymal stem cells transplanted in the infarcted myocardium. Int J Nanomedicine: 2015, 10;1679-1690 PMID: 25767388
- Human Embryology (2nd ed.) Larson Chapter 10 p261-306
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Chapter 13 p303-346
- Before We Are Born (5th ed.) Moore and Persaud Chapter 14 p289-326
- Essentials of Human Embryology, Larson Chapter 10 p173-205
- Human Embryology, Fitzgerald and Fitzgerald Chapter 21-22 p134-152
- Developmental Biology (6th ed.) Gilbert Chapter 14 Intermediate Mesoderm
|Urogenital Sinus||Urogenital Septum|
Three main stages during development, mesonephric/paramesonephric duct changes are one of the first male/female differences that occur in development, while external genitaila remain indeterminate in appearance for quite a while.
- Differentiation of gonad (Sex determination)
- Differentiation of internal genital organs
- Differentiation of external genital organs
The 2nd and 3rd stages dependent on endocrine gonad. Reproductive development has a long maturation timecourse, begining in the embryo and finishing in puberty. (More? Puberty Development)
Gonad - Ovary
Primordial germ cell migration (mouse)
|Migration 1||Migration 2||Migration 3|
Historic Images of Genital Changes
|Urogenital indifferent||Urogenital female|
Fetal Week 10
- Laurent Boulanger, Maëlle Pannetier, Laurence Gall, Aurélie Allais-Bonnet, Maëva Elzaiat, Daniel Le Bourhis, Nathalie Daniel, Christophe Richard, Corinne Cotinot, Norbert B Ghyselinck, Eric Pailhoux FOXL2 is a female sex-determining gene in the goat. Curr. Biol.: 2014, 24(4);404-8 PMID: 24485832
- Congxing Lin, Yan Yin, G Michael Veith, Alexander V Fisher, Fanxin Long, Liang Ma Temporal and spatial dissection of Shh signaling in genital tubercle development. Development: 2009, 136(23);3959-67 PMID: 19906863
- Xinyu Wu, Christopher Ferrara, Ellen Shapiro, Irina Grishina Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium. Gene Expr. Patterns: 2009, 9(4);224-30 PMID: 19159697
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Cite this page: Hill, M.A. (2015) Embryology Genital - Female Development. Retrieved April 18, 2015, from https://embryology.med.unsw.edu.au/embryology/index.php/Genital_-_Female_Development
- © Dr Mark Hill 2015, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G