File:Cloacal septation model.jpg
Cloacal_septation_model.jpg (600 × 408 pixels, file size: 38 KB, MIME type: image/jpeg)
Model for cloacal septation
(A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line.
(B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.
Reference
<pubmed>22253716</pubmed>| PLoS One.
Citation: Xu K, Wu X, Shapiro E, Huang H, Zhang L, et al. (2012) Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation. PLoS ONE 7(1): e29372. doi:10.1371/journal.pone.0029372
Copyright: © 2012 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 23:27, 18 April 2012 | | 600 × 408 (38 KB) | Z8600021 (talk | contribs) | ==Model for cloacal septation== (A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK acti |
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