File:Age-related chromosome segregation errors during MI model.jpg

Premature bivalent separation into univalents precedes age-related chromosome segregation errors during Meiosis i (MI)

Bivalents with weakened cohesion in aged oocytes undergo hyperstretching and separation into univalents by microtubule-mediated bipolar spindle forces.

This bipolar forces in turn biorient the sister kinetochores (KTs) of the univalents. The univalents are therefore strongly biased towards predivision of sister chromatids, including balanced predivision. After balanced predivision during MI, the chromatids undergo random segregation during MII.

Links: Oocyte Development | Meiosis | Trisomy 21

Reference

Sakakibara Y, Hashimoto S, Nakaoka Y, Kouznetsova A, Höög C & Kitajima TS. (2015). Bivalent separation into univalents precedes age-related meiosis I errors in oocytes. Nat Commun , 6, 7550. PMID: 26130582 DOI.

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Figure 5 altered in size and labelling. Above text from figure legend.

Cite this page: Hill, M.A. (2024, April 25) Embryology Age-related chromosome segregation errors during MI model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Age-related_chromosome_segregation_errors_during_MI_model.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G