Introduction
This lecture is an introduction to the animal models of
development. The key components covered are: models,
historic models, invertebrate models, vertebrate models,
worm, c. elegans, fly, drosophila, frog,
xenopus, chicken, mouse, rat, guinea pig, pig.
The lecture slides and textbook alone contain enough
information as an introduction to the subject for this level
of study. If you are interested in further reading, I have
also included below links to more detailed textbooks with
further information and images. Please note this additional
information is not necessarily examinable, but may be useful
if you have not previously studied biology.
The link below to lecture slides allows you to open and
view the slides in your web browser or download the PDF
document for later viewing/printing. The online text
Developmental
Biology links listed below are worth reviewing for
this lecture.
Lecture Slides
Link to lecture slides allows you to open and view the slides in your web
browser or download the PDF document for later viewing/printing. Download
Acrobat Reader 6.0
Lecture 7 1slide/page (view only) (xx pages, x Mb)
Lecture 7 4slides/page (print) (xx pages, x Kb)
Lecture 7 6slides/page (print) (xx pages, x Kb)
Lecture 7 outline (print no images) (xx pages, x Kb)
Online Resources
Laboratory 1 introduced several online resources
that will be used throughout the session. Listed
Below are links to these resources. The key
resourse used will be UNSW Embryology (which
is also available on CD from Anatomy Office). Links
to material within UNSW Embryology relevant
to this lecture are given below.
- UNSW
Embryology
- Week
3 Notes These notes cover the
third week of development key aspects of
which are: gastrulation, neural tube, somite,
cardiovascular development. The
intraembryonic spaces (coelom) and the
primitive placenta (villi) also continue to
develop.
- Musculoskeletal
Development The musculoskeletal
system consists of skeletal muscle, bone, and
cartilage and is mainly mesoderm in origin
with some neural crest contribution.
The intraembryonic mesoderm can be broken
into paraxial, intermediate and lateral
mesoderm relative to its midline position.
During the 3rd week the paraxial mesoderm
forms into "balls" of mesoderm paired either
side of the neural groove, called somites .
Somites appear bilaterally as pairs at the
same time and form earliest at the cranial
(rostral,brain) end of the neural groove and
add sequentially at the caudal end. This
addition occurs so regularly that embryos are
staged according to the number of somites
that are present. Different regions of the
somite differentiate into dermomyotome
(dermal and muscle component) and sclerotome
(forms vertebral column). An example of a
specialized musculoskeletal structure can be
seen in the development of the limbs.
- Embryo
Images Online These are scanning
electron micrographs of early embryonic
development. These images are not relevant to
the first few weeks of lectures.
- Larsen
Textbook Online
Molecular Biology of the
Cell
Below are listed links that
relate to this Lecture from the textbook "Molecular
Biology of the Cell" which is available free
online. You can either click the provided links or
do your own search using the search link.
(http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?call=bv.View..ShowTOC&rid=cell.TOC&depth=2)
- Search
Molecular Biology of the Cell
- Search
Molecular Biology of the Cell - Neural
Development (20 items)
- Neural
Development
Other Online
Texts
Online Books
Developmental Biology
Developmental Biology. 6th ed. Gilbert, Scott F. Sunderland
(MA): Sinauer Associates, Inc.; c2000.
Below are listed links that relate to this Lecture from the textbook "Developmental
Biology" which is available free online. You can either click the provided
links or do your own search using the search link.
Search
Developmental Biology
Molecular Biology of the Cell
3rd ed. Alberts, Bruce; Bray, Dennis; Lewis, Julian; Raff,
Martin; Roberts, Keith; Watson, James D. New York and London: Garland Publishing;
c1994.
Below are listed links that relate to this Lecture from the textbook "Molecular
Biology of the Cell" which is available free online. You can either click
the provided links or do your own search using the search link.
Search
Molecular Biology of the Cell
MBoC Search Results(click
text link below to see search results)
Online Mendelian Inheritance in Man
OMIM
Comments
This sixth lecture looks at mesoderm development.
The mesoderm contribute many different structures to the embryo: heart, kidneys, connective tissues, bone, muscle.
Please email Dr Mark Hill if you wish to make a comment about this current project.
