UNSW Embryo- Development of the Urogenital System.PubMed Selected References |
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Note: A Selected List of References from PubMed March 1999 search results for "Pax/wilms tumour" is available for computers within School of Anatomy without Internet access. Access to abstracts from these computers is not available. |
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- Dressler GR. [See Related Articles]
- Pax-2, kidney development, and oncogenesis.
Med Pediatr Oncol. 1996 Nov;27(5):440-4. Review.
PMID: 8827071; UI: 96424610.
The development of a complex tissue from a few simple precursor cells requires the precise activation and repression of tissue-specific genes that determine cell lineages, tissue patterning, and cellular proliferation. In the kidney, a number of recently identified genes are critical for normal development. Among these, the Pax-2 gene encodes a transcription factor that is expressed in the ureter bud, in the induced kidney mesenchyme, and in the progenitor cells of the glomerular and tubular epithelium. Although the differentiation of the renal epithelium requires Pax-2 function, failure to suppress the gene in mature epithelium is detrimental to normal renal function. Recent, data suggest that the Wilms' tumor-suppressor gene WT1 can down-regulate Pax-2 expression, consistent with high levels of Pax-2 in Wilms' tumors. Additional studies suggest that reactivation of this developmental regulator can contribute to a variety of other renal diseases. - Emerging roles for PAX transcription factors in
cancer biology.
Gen Physiol Biophys. 1998 Sep;17(3):211-24. Review.
PMID: 9834843; UI: 99051908.
- Haltia
A, et al.
[See
Related Articles]
- Expression of nine developmental stage-specific genes
in human kidney and cultured renal cells.
Exp Nephrol. 1997 Nov-Dec;5(6):457-64.
PMID: 9438174; UI: 98101055.
- Fraizer
GC, et al.
[See
Related Articles]
- PAX 8 regulates human WT1 transcription through a
novel DNA binding site.
J Biol Chem. 1997 Dec 5;272(49):30678-87.
PMID: 9388203; UI: 98049525.
- Discenza
MT, et al.
[See
Related Articles]
- Overlapping DNA recognition motifs between Sp1 and a
novel trans-acting factor within the wt1 tumour
suppressor gene promoter.
Nucleic Acids Res. 1997 Nov 1;25(21):4314-22.
PMID: 9336463; UI: 97478561.
- Poleev
A, et al.
[See
Related Articles]
- Determination of functional domains of the human
transcription factor PAX8 responsible for its nuclear
localization and transactivating potential.
Eur J Biochem. 1997 Aug 1;247(3):860-9.
PMID: 9288908; UI: 97433268.
- McConnell
MJ, et al.
[See
Related Articles]
- Differential regulation of the human Wilms tumour
suppressor gene (WT1) promoter by two isoforms of
PAX2.
Oncogene. 1997 Jun 5;14(22):2689-700.
PMID: 9178767; UI: 97322113. - Dehbi
M, et al.
[See
Related Articles]
- PAX8-mediated activation of the wt1 tumor suppressor
gene.
EMBO J. 1996 Aug 15;15(16):4297-306.
PMID: 8861958; UI: 97015130.
- Davies
JA.
[See
Related Articles]
- Mesenchyme to epithelium transition during
development of the mammalian kidney tubule.
Acta Anat (Basel). 1996;156(3):187-201. Review.
PMID: 9124036; UI: 97183734.
- Dressler
GR.
[See
Related Articles]
- Transcription factors in renal development: the WT1
and Pax-2 story.
Semin Nephrol. 1995 Jul;15(4):263-71. Review.
PMID: 7569406; UI: 96055843.
- Poleev
A, et al.
[See
Related Articles]
- Distinct functional properties of three human
paired-box-protein, PAX8, isoforms generated by
alternative splicing in thyroid, kidney and Wilms'
tumors.
Eur J Biochem. 1995 Mar 15;228(3):899-911.
PMID: 7737192; UI: 95255300.
- Eccles
MR, et al.
[See
Related Articles]
- Comparative in situ hybridization analysis of PAX2,
PAX8, and WT1 gene transcription in human fetal kidney
and Wilms' tumors.
Am J Pathol. 1995 Jan;146(1):40-5.
PMID: 7856737; UI: 95160120.
- Sharma
PM, et al.
[See
Related Articles]
- A rodent model for Wilms tumors: embryonal kidney
neoplasms induced by N-nitroso-N'-methylurea.
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9931-5.
PMID: 7937920; UI: 95024075.
- Hazen-Martin
DJ, et al.
[See
Related Articles]
- Distinctive properties of an anaplastic Wilms' tumor
and its associated epithelial cell line.
Am J Pathol. 1994 May;144(5):1023-34.
PMID: 8178926; UI: 94234265.
- Tagge
EP, et al.
[See
Related Articles]
- Paired box gene expression in Wilms' tumor.
J Pediatr Surg. 1994 Feb;29(2):134-41.
PMID: 7909843; UI: 94231398.
- Clapp
WL, et al.
[See
Related Articles]
- Regulation of kidney organogenesis: homeobox genes,
growth factors, and Wilms tumor.
Curr Opin Nephrol Hypertens. 1993 May;2(3):419-29. Review.
PMID: 7922202; UI: 95006501.
- Fantes
JA, et al.
[See
Related Articles]
- Submicroscopic deletions at the WAGR locus, revealed
by nonradioactive in situ hybridization.
Am J Hum Genet. 1992 Dec;51(6):1286-94.
PMID: 1334370; UI: 93098243.
- Dressler
GR, et al.
[See
Related Articles]
- Pax-2 is a DNA-binding protein expressed in embryonic
kidney and Wilms tumor.
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1179-83.
PMID: 1311084; UI: 92159012.