UNSW Embryo- Development of the Nervous System. Selected References- Retinoic Acid Back to Neural Notes selected refs / page 1 / page 2 Articles | Reviews | Books Links: Page 2 Page 1 PubMed Link About PubMed Note: A Selected List of References for Neural Development from PubMed March 1999. It was too difficult to keep neural development to one page so I have selected a few current Articles below and given a short description of the relevance to specific aspects of neural development. Internet access computers will be able to get abstract directly from PubMed (when available) by clicking Abstract below.

Articles Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 1996 May 16;381(6579):238-41 Zhang J, Hagopian-Donaldson S, Serbedzija G, Elsemore J, Plehn-Dujowich D, McMahon AP, Flavell RA, Williams T The retinoic acid-inducible transcription factor AP-2 is expressed in epithelial and neural crest cell lineages during murine development. AP-2 can regulate neural and epithelial gene transcription, and is associated with overexpression of c-erbB-2 in human breast-cancer cell lines. To ascertain the importance of AP-2 for normal development, we have derived mice containing a homozygous disruption of the AP-2 gene. These AP-2-null mice have multiple congenital defects and die at birth. In particular, the AP-2 knockout mice exhibit anencephaly, craniofacial defects and thoraco-abdominoschisis. Skeletal defects occur in the head and trunk region, where many bones are deformed or absent. Analysis of these mice earlier in embryogenesis indicates a failure of cranial neural-tube closure and defects in cranial ganglia development. We have shown that AP-2 is a fundamental regulator of mammalian craniofacial development. Reviews  A decade of molecular biology of retinoic acid receptors. Chambon P FASEB J 1996 Jul;10(9):940-54 Two families of retinoid acid (RA) receptors (R), the RAR isotypes (alpha, beta, and gamma) and the three RXR isotypes (alpha, beta, and gamma), and their numerous isoforms, which bind as RXR/RAR heterodimers to the polymorphic cis-acting response elements of RA target genes. Regulation and regulatory role of the retinoids. Ng KW, Zhou H, Manji S, Martin TJ Crit Rev Eukaryot Gene Expr 1995;5(3-4):219-53 Multiplicity generates diversity in the retinoic acid signalling pathways. Leid M, Kastner P, Chambon P Trends Biochem Sci 1992 Oct;17(10):427-33 Books