UNSW Embryo- Development of the Nervous System

Selected References- Hox homeobox genes.

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Note: A Selected List of References for Neural Development from PubMed March 1999.

It was too difficult to keep neural development to one page so I have selected a few current Articles below and given a short description of the relevance to specific aspects of neural development.

Internet access computers will be able to get abstract directly from PubMed (when available) by clicking Abstract below.

Articles

  • Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis. Holland PW, Hogan BL Development 1988 Jan;102(1):159-74 Abstract |
    • MH- historic paper that moved from drosophila to vertebrate development of the Hox gene family.
    • Hox= The homeobox is a 180-base-pair sequence characteristically found in homeotic and segmentation genes in Drosophila.
  • Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system.Toth LE, Slawin KL, Pintar JE, Nguyen-Huu MC Proc Natl Acad Sci U S A 1987 Oct;84(19):6790-4
    • MH- historic paper that moved from drosophila to vertebrate development of the Hox gene family.
  • Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson JNature 1999 Apr 15;398(6728):622-7 Abstract |
    • MH- A recent paper describing the downstream genes responding to shh in the nervous system.
      • Patched and Smoothened are shh receptors and the GLI family of transcription facotrs is also downstream.
  • The role of kreisler in segmentation during hindbrain development. Manzanares M, Trainor PA, Nonchev S, Ariza-McNaughton L, Brodie J, Gould A, Marshall H, Morrison A, Kwan CT, Sham MH, Wilkinson DG, Krumlauf R Dev Biol 1999 Jul 15;211(2):220-37 Abstract |


Reviews

  • Evolution of the vertebrate Hox homeobox genes. Krumlauf R Bioessays 1992 Apr;14(4):245-52 Abstract |
  • Hox genes and chordate evolution. Holland PW, Garcia-Fernandez J Dev Biol 1996 Feb 1;173(2):382-95 Abstract | Full Text |
  • Drosophila Hox complex downstream targets and the function of homeotic genes. Graba Y, Aragnol D, Pradel J Bioessays 1997 May;19(5):379-88 Abstract |
  • Retinoid-regulated gene expression in neural development. Clagett-Dame M, Plum LA Crit Rev Eukaryot Gene Expr 1997;7(4):299-342

 


Books