UNSW Embryo- Development of the Nervous System.Selected References- Dorsalin |
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Note: A Selected List of References for Neural Development from PubMed March 1999. |
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It was too difficult to keep neural development to one page so I have selected a few current Articles below and given a short description of the relevance to specific aspects of neural development. Internet access computers will be able to get abstract directly from PubMed (when available) by clicking Abstract below. |
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Articles
Dorsalin
- Control of cell pattern in the neural tube:
regulation of cell differentiation by dorsalin-1, a novel
TGF beta family member. Basler K, Edlund T, Jessell
TM, Yamada T Cell 1993 May 21;73(4):687-702 Abstract
| Related
Articles |
- MH- with shh specifying ventral neural tube, dorsalin patterns dorsal neural tube. These 2 factors appear to act in a graded concentration fashion (closer -> distant) competitively with each other. TGF-beta is an enormous growth factor family (superfamily) with many different roles in development and the mature animal.
Reviews
- The specification of dorsal cell fates in the
vertebrate central nervous system. Lee KJ, Jessell TM
Annu Rev Neurosci 1999;22:261-94
- The generation of distinct classes of neurons at defined positions within the developing vertebrate nervous system depends on inductive signals provided by local cell groups that act as organizing centers. Genetic and embryological studies have begun to elucidate the processes that control the pattern and identity of neuronal cell types. Here we discuss the cellular interactions and molecular mechanisms that direct neuronal cell fates in the dorsal half of the vertebrate central nervous system. The specification of dorsal neuronal cell fates appears to depend on a cascade of inductive signals initiated by cells of the epidermal ectoderm that flank the neural plate and propagated by roof plate cells within the neural tube. Members of the transforming growth factor-beta (TGF beta) family of secreted proteins have a prominent role in mediating these dorsalizing signals. Additional signals involving members of the Wnt and fibroblast growth factor (FGF) families may also contribute to the proliferation and differentiation of dorsal neuronal cell types.